The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Plakoglobin and β-catenin: Protein interactions, regulation and biological roles
Abstract
β-Catenin can play different roles in the cell, including one as a structural protein at cell-cell adherens junctions and another as a transcriptional activator mediating Wnt signal transduction. Plakoglobin (γ-catenin), a close homolog of β-catenin, shares with β-catenin common protein partners and can fulfill some of the same functions. The complexing of catenins with various protein partners is regulated by phosphorylation and by intramolecular interactions. The competition between different catenin partners for binding to catenins mediates the cross-talk between cadherin-based adhesion, catenin-dependent transcription and Wnt signaling. Although plakoglobin differs from β-catenin in its functions and is unable to compensate for defects in Wnt signaling resulting from lack of β-catenin, recent evidence suggests that plakoglobin plays a unique role in Wnt signaling that is different from that of β-catenin. The functional difference between catenins is reflected in their differential involvement in embryonic development and cancer progression.
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Cites
Functional interaction of β-catenin with the transcription factor LEF-1
Behrens, J., von Kries, J. P., Kühl, M., Bruhn, L., Wedlich, D., Grosschedl, R., & Birchmeier, W. (1996) · Nature · doi:10.1038/382638a0 · Cited by 2,912
Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation
Heisenberg, C.-P., Tada, M., Rauch, G.-J., Saúde, L., Concha, M. L., Geisler, R., Stemple, D. L., Smith, J. C., & Wilson, S. W. (2000) · Nature · doi:10.1038/35011068 · Cited by 1,013
Ishitani, T., Ninomiya-Tsuji, J., Nagai, S.-I., Nishita, M., Meneghini, M., Barker, N., Waterman, M., Bowerman, B., Clevers, H., Shibuya, H., et al. (1999) · Nature · doi:10.1038/21674 · Cited by 621
Fagotto, F., Glück, U., & Gumbiner, B. M. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70082-x · Cited by 434
Yamamoto, H., Kishida, S., Kishida, M., Ikeda, S., Takada, S., & Kikuchi, A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.16.10681 · Cited by 364
Control of β-Catenin Stability
Salic, A., Lee, E., Mayer, L., & Kirschner, M. W. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80446-3 · Cited by 335
Cited by
Desmosome structure, composition and function
Garrod, D., & Chidgey, M. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.07.014 · Cited by 580
Cheng, C. Y., & Mruk, D. D. (2002) · Physiological Reviews · doi:10.1152/physrev.00009.2002 · Cited by 567
The cadherin-catenin adhesion system in signaling and cancer
Conacci-Sorrell, M., Zhurinsky, J., & Ben-Ze’ev, A. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15429 · Cited by 532
Self-citationKirchhof, P., Fabritz, L., Zwiener, M., Witt, H., Schäfers, M., Zellerhoff, S., Paul, M., Athai, T., Hiller, K.-H., Baba, H. A., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.624502 · Cited by 429
DIRECT EVIDENCE FOR A ROLE OF β‐CATENIN/LEF‐1 SIGNALING PATHWAY IN INDUCTION OF EMT
Kim, K., Lu, Z., & Hay, E. D. (2002) · Cell Biology International · doi:10.1006/cbir.2002.0901 · Cited by 428
Metadata
- Authors
- Zhurinsky, J., Shtutman, M., & Ben-Ze′ev, A.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2000-09-15
- Volume
- 113
- Issue
- 18
- Pages
- 3127-3139
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W1936593340
- Cited by
- 348
- References
- 6
- FWCI
- 6.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhurinsky, J., Shtutman, M., & Ben-Ze′ev, A. (2000). Plakoglobin and β-catenin: Protein interactions, regulation and biological roles. Journal of Cell Science. https://doi.org/10.1242/jcs.113.18.3127
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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