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Cited by 450

The DOI matches its Crossref record; 92 of the 92 references it cites were found in a registry or an index.

The organisation and functions of local Ca2+ signals

Bootman, Martin D., Lipp, Peter, Berridge, Michael J.·2001·Journal of Cell Science

Abstract

Calcium (Ca2+) is a ubiquitous intracellular messenger, controlling a diverse range of cellular processes, such as gene transcription, muscle contraction and cell proliferation. The ability of a simple ion such as Ca2+ to play a pivotal role in cell biology results from the facility that cells have to shape Ca2+ signals in space, time and amplitude. To generate and interpret the variety of observed Ca2+ signals, different cell types employ components selected from a Ca2+ signalling ‘toolkit’, which comprises an array of homeostatic and sensory mechanisms. By mixing and matching components from the toolkit, cells can obtain Ca2+ signals that suit their physiology. Recent studies have demonstrated the importance of local Ca2+ signals in defining the specificity of the interaction of Ca2+ with its targets. Furthermore, local Ca2+ signals are the triggers and building blocks for larger global signals that propagate throughout cells.

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Crossref · 10.1242/jcs.114.12.2213

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Metadata

Authors
Bootman, M. D., Lipp, P., & Berridge, M. J.
Venue
Journal of Cell Science
Published
2001-06-15
Volume
114
Issue
12
Pages
2213-2222
ISSN
  • 0021-9533 (ISSN-L)
  • 1477-9137
OpenAlex
W2150942343
Cited by
450
References
92
FWCI
18.41
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: The organisation and functions of local Ca2+ signals. https://app.cochat.ai/papers/10.1242/jcs.114.12.2213
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Bootman, M. D., Lipp, P., & Berridge, M. J. (2001). The organisation and functions of local Ca2+ signals. Journal of Cell Science. https://doi.org/10.1242/jcs.114.12.2213

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.