The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.
Vesicle tethering complexes in membrane traffic
Abstract
Despite the recent progress in the field of membrane traffic, the question of how the specificity of membrane fusion is achieved has yet to be resolved. It has become apparent that the SNARE proteins, although central to the process of fusion, are often not the first point of contact between a vesicle and its target. Instead, a poorly understood tethering process physically links the two before fusion occurs. Many factors that have an apparent role in tethering have been identified. Among these are several large protein complexes. Until recently, these seemed unrelated, which was a surprise since proteins involved in membrane traffic often form families, members of which function in each transport step. Recent work has shown that three of the complexes are in fact related. We refer to these as the `quatrefoil' tethering complexes, since they appear to share a fourfold nature. Here we describe the quatrefoil complexes and other, unrelated, tethering complexes, and discuss ideas about their function. We propose that vesicle tethering may have separate kinetic and thermodynamic elements and that it may be usefully divided into events upstream and downstream of the function of Rab GTPases. Moreover, the diversity of tethering complexes in the cell suggests that not all tethering events occur through the same mechanisms.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Functional organization of the yeast proteome by systematic analysis of protein complexes
Gavin, A.-C., Bösche, M., Krause, R., Grandi, P., Marzioch, M., Bauer, A., Schultz, J., Rick, J. M., Michon, A.-M., Cruciat, C.-M., et al. (2002) · Nature · doi:10.1038/415141a · Cited by 4,759
Rab proteins as membrane organizers
Zerial, M., & McBride, H. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35052055 · Cited by 3,381
Wilschut, J. (1990) · Cited by 2,407
Joazeiro, C. A. P., & Weissman, A. M. (2000) · Cell · doi:10.1016/s0092-8674(00)00077-5 · Cited by 1,249
SNARE-mediated membrane fusion
Chen, Y. A., & Scheller, R. H. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35052017 · Cited by 1,130
The Rab5 effector EEA1 is a core component of endosome docking
Christoforidis, S., McBride, H. M., Burgoyne, R. D., & Zerial, M. (1999) · Nature · doi:10.1038/17618 · Cited by 854
The Exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae.
TerBush, D. R., Maurice, T., Roth, D., & Novick, P. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01039.x · Cited by 852
Raymond, C. K., Howald-Stevenson, I., Vater, C. A., & Stevens, T. H. (1992) · Molecular Biology of the Cell · doi:10.1091/mbc.3.12.1389 · Cited by 840
Three-dimensional structure of the neuronal-Sec1–syntaxin 1a complex
Misura, K. M. S., Scheller, R. H., & Weis, W. I. (2000) · Nature · doi:10.1038/35006120 · Cited by 785
A genomic perspective on membrane compartment organization
Bock, J. B., Matern, H. T., Peden, A. A., & Scheller, R. H. (2001) · Nature · doi:10.1038/35057024 · Cited by 696
Cited by
Schuldiner, M., Collins, S. R., Thompson, N. J., Denic, V., Bhamidipati, A., Punna, T., Ihmels, J., Andrews, B., Boone, C., Greenblatt, J. F., et al. (2005) · Cell · doi:10.1016/j.cell.2005.08.031 · Cited by 870
BI-DIRECTIONAL PROTEIN TRANSPORT BETWEEN THE ER AND GOLGI
Lee, M. C. S., Miller, E. A., Goldberg, J., Orci, L., & Schekman, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.105307 · Cited by 813
Boyd, C., Hughes, T., Pypaert, M., & Novick, P. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200408124 · Cited by 312
Peplowska, K., Markgraf, D. F., Ostrowicz, C. W., Bange, G., & Ungermann, C. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.03.006 · Cited by 309
The exocyst defrocked, a framework of rods revealed
Munson, M., & Novick, P. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1097 · Cited by 290
Metadata
- Authors
- Whyte, J. R. C., & Munro, S.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2002-07-01
- Volume
- 115
- Issue
- 13
- Pages
- 2627-2637
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2102285200
- Cited by
- 455
- References
- 101
- FWCI
- 12.80
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Vesicle tethering complexes in membrane traffic. https://app.cochat.ai/papers/10.1242/jcs.115.13.2627
- The paper
- Whyte, J. R. C., & Munro, S. (2002). Vesicle tethering complexes in membrane traffic. Journal of Cell Science. https://doi.org/10.1242/jcs.115.13.2627
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
