The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
Autophagy and microtubules - new story, old players
Abstract
Summary: Both at a basal level and after induction (especially in response to nutrient starvation), the function of autophagy is to allow cells to degrade and recycle damaged organelles, proteins and other biological constituents. Here, we focus on the role microtubules have in autophagosome formation, autophagosome transport across the cytoplasm and in the formation of autolysosomes. Recent insights into the exact relationship between autophagy and microtubules now point to the importance of microtubule dynamics, tubulin post-translational modifications and microtubule motors in the autophagy process. Such factors regulate signaling pathways that converge to stimulate autophagosome formation. They also orchestrate the movements of pre-autophagosomal structures and autophagosomes or more globally organize and localize immature and mature autophagosomes and lysosomes. Most of the factors that now appear to link microtubules to autophagosome formation or to autophagosome dynamics and fate were identified initially without the notion that sequestration, recruitment and/or interaction with microtubules contribute to their function. Spatial and temporal coordination of many stages in the life of autophagosomes thus underlines the integrative role of microtubules and progressively reveals hidden parts of the autophagy machinery.
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“Post-translational modifications of tubulin such as acetylation and tyrosination/detyrosination can act either singly or in concert with other modifications to control motor recruitment in a cargo-specific manner (Hammond et al., 2008; Mackeh et al., 2013).”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as Mackeh et al., 2013
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Cites
1 retracted
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RetractedAMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
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Autophagy: Renovation of Cells and Tissues
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Autophagy and the Integrated Stress Response
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Dynamic instability of microtubule growth
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The Role of Atg Proteins in Autophagosome Formation
Mizushima, N., Yoshimori, T., & Ohsumi, Y. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154005 · Cited by 2,978
MICROTUBULE POLYMERIZATION DYNAMICS
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The Beclin 1 network regulates autophagy and apoptosis
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Coulon, P.-G. A. (2014) · theses.fr (ABES) · doi:10.70675/35505ce2z6226z4be3z9fc3za30de5ecacdc
Role of p27/Kip1 in auphagy under metabolic stress conditions
Nowosad, A. (2018) · theses.fr (ABES) · doi:10.70675/11eb36d1zc3baz4d74z8d00zc049667c5976
Cao, X., Zhang, H., & Wang, J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1732775
“The cytoskeleton, serving as the structural basis for autophagosome formation and transport, plays a key role in this regulation (160).”
Evolution of Resistance to Avian Malaria Infection in an Endemic Hawaiian Honeycreeper
Neddermeyer, J. H., Cassin‐Sackett, L., Paxton, E. H., Campana, M. G., Fleischer, R. C., & Foster, J. T. (2026) · Ecology and Evolution · doi:10.1002/ece3.73550
“Microtubules play an important role in the autophagy process through the assembly and transport of autophagosomes to lysosomes (Mackeh et al. 2013; Monastyrska et al. 2009 of autophagosomes via microtubules in response to malaria infection.”
Ruso-López, M., Pérez-Díaz, A. J., & Prieto-Ruiz, F. (2026) · Precision Oncology · doi:10.3390/precisoncol1030010
“Microtubules are filaments composed of β -tubulin subunits that drive autophago-some movement towards lysosomes, participating in autophagosome–lysosome fusion and late autophagosome formation [70–72].”
Toledo, A., Simoes, P., Fernández-Tabó, C., Mir, K. H., Chávez‐Genaro, R., & Anesetti, G. (2026) · Reproductive Biology · doi:10.1016/j.repbio.2026.101267
Suri, P., Daartey, A. B., Khan, D. M. I. O., Rayana, N. P., Chilamakuri, R., Godugu, D., Azad, M. G., Reeb, K. L., & Richardson, D. R. (2026) · Pharmacological Reviews · doi:10.1016/j.pharmr.2026.100158
Autophagy-lysosomal pathway in neurodegeneration
McDonough, S. R., Rao, A. K., McAleer, J. M., Babrowicz, B. M., & Sharma, M. (2026) · Molecular Neurodegeneration Advances · doi:10.1186/s44477-026-00041-0
BindingDB (2025) · UC San Diego · doi:10.7270/q2474gh9
Metadata
- Authors
- Mackeh, R., Perdiz, D., Lorin, S., Codogno, P., & Poüs, C.
- Affiliations
- Université Paris-Sud (FR)
- Inserm (FR)
- Corresponding author
- Codogno, Patrice
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2013-03-01
- Volume
- 126
- Issue
- 5
- Pages
- 1071-1080
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2098921256
- Semantic Scholar
- bd987f4dde12826f66e2891ff2e65de145d37370
- Cited by
- 212
- References
- 110
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 13 · 2023: 13 · 2022: 20 · 2021: 20 · 2020: 20 · 2019: 21 · 2018: 17 · 2017: 20 · 2016: 16 · 2015: 10 · 2014: 18 · 2013: 3
- FWCI
- 11.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cell Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- autophagy, microtubules, autophagosome formation, autophagosome transport, autolysosomes, microtubule dynamics, tubulin post-translational modifications, microtubule motor proteins, nutrient deprivation, organelle degradation
- MeSH terms
- Animals, Autophagy, Humans, Lysosomes, Microtubules, Models, Biological, Phagocytosis, Protein Processing, Post-Translational, Tubulin
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