The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
Autophagy and microtubules - new story, old players
Abstract
Summary: Both at a basal level and after induction (especially in response to nutrient starvation), the function of autophagy is to allow cells to degrade and recycle damaged organelles, proteins and other biological constituents. Here, we focus on the role microtubules have in autophagosome formation, autophagosome transport across the cytoplasm and in the formation of autolysosomes. Recent insights into the exact relationship between autophagy and microtubules now point to the importance of microtubule dynamics, tubulin post-translational modifications and microtubule motors in the autophagy process. Such factors regulate signaling pathways that converge to stimulate autophagosome formation. They also orchestrate the movements of pre-autophagosomal structures and autophagosomes or more globally organize and localize immature and mature autophagosomes and lysosomes. Most of the factors that now appear to link microtubules to autophagosome formation or to autophagosome dynamics and fate were identified initially without the notion that sequestration, recruitment and/or interaction with microtubules contribute to their function. Spatial and temporal coordination of many stages in the life of autophagosomes thus underlines the integrative role of microtubules and progressively reveals hidden parts of the autophagy machinery.
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“Post-translational modifications of tubulin such as acetylation and tyrosination/detyrosination can act either singly or in concert with other modifications to control motor recruitment in a cargo-specific manner (Hammond et al., 2008; Mackeh et al., 2013).”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as Mackeh et al., 2013
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Cites
1 retracted
Acharya, B. R., Bhattacharyya, S., Choudhury, D., & Chakrabarti, G. (2011) · APOPTOSIS · doi:10.1007/s10495-011-0613-1 · Cited by 69
RetractedAMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227
Autophagy: Renovation of Cells and Tissues
Mizushima, N., & Komatsu, M. (2011) · Cell · doi:10.1016/j.cell.2011.10.026 · Cited by 6,615
Microtubules as a target for anticancer drugs
Jordan, M. A., & Wilson, L. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1317 · Cited by 4,000
Levine, B., & Klionsky, D. J. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00099-1 · Cited by 3,728
Autophagy and the Integrated Stress Response
Kroemer, G., Mariño, G., & Levine, B. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.023 · Cited by 3,506
Dynamic instability of microtubule growth
Mitchison, T., & Kirschner, M. (1984) · Nature · doi:10.1038/312237a0 · Cited by 3,337
The Role of Atg Proteins in Autophagosome Formation
Mizushima, N., Yoshimori, T., & Ohsumi, Y. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154005 · Cited by 2,978
MICROTUBULE POLYMERIZATION DYNAMICS
Desai, A. B., & Mitchison, T. J. (1997) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.13.1.83 · Cited by 2,660
The Beclin 1 network regulates autophagy and apoptosis
Kang, R., Zeh, H. J., Lotze, M. T., & Tang, D. (2011) · Cell Death & Differentiation · doi:10.1038/cdd.2010.191 · Cited by 2,485
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The cell biology of the retinal pigment epithelium
Lakkaraju, A., Umapathy, A., Tan, L. X., Daniele, L., Philp, N. J., Boesze-Battaglia, K., & Williams, D. S. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100846 · Cited by 422
“Post-translational modifications of tubulin such as acetylation and tyrosination/detyrosination can act either singly or in concert with other modifications to control motor recruitment in a cargo-specific manner (Hammond et al., 2008; Mackeh et al., 2013).”
BackgroundThe Cytoskeleton-Autophagy Connection
Kast, D. J., & Dominguez, R. (2017) · Current Biology · doi:10.1016/j.cub.2017.02.061 · Cited by 267
Mitophagy in Cancer: A Tale of Adaptation
Vara‐Pérez, M., Felipe‐Abrio, B., & Agostinis, P. (2019) · Cells · doi:10.3390/cells8050493 · Cited by 264
“autophagy (and mitophagy by extension) is highly sensitive to microtubule-dynamics modulators since microtubules are essential for the autophagosome fusion with the lysosome [295,296].”
BackgroundAutophagy regulation and its role in cancer
Lorin, S., Hamaï, A., Mehrpour, M., & Codogno, P. (2013) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2013.06.007 · Cited by 261
Self-citationPharmacologic agents targeting autophagy
Vakifahmetoglu-Norberg, H., Xia, H., & Yuan, J. (2015) · Journal of Clinical Investigation · doi:10.1172/jci73937 · Cited by 247
“The destabilization of microtubules by either vinblastine (64), nocodazole, or cytochalasin B and D blocks the maturation of autophagosomes (65); conversely, taxol-mediated microtubule stabilization increases the fusion between autophagic vacuoles and lysosomes (66, 67).”
Metadata
- Authors
- Mackeh, R., Perdiz, D., Lorin, S., Codogno, P., & Poüs, C.
- Affiliations
- Université Paris-Sud (FR)
- Inserm (FR)
- Corresponding author
- Codogno, Patrice
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2013-03-01
- Volume
- 126
- Issue
- 5
- Pages
- 1071-1080
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2098921256
- Semantic Scholar
- bd987f4dde12826f66e2891ff2e65de145d37370
- Cited by
- 212
- References
- 110
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 13 · 2023: 13 · 2022: 20 · 2021: 20 · 2020: 20 · 2019: 21 · 2018: 17 · 2017: 20 · 2016: 16 · 2015: 10 · 2014: 18 · 2013: 3
- FWCI
- 11.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cell Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- autophagy, microtubules, autophagosome formation, autophagosome transport, autolysosomes, microtubule dynamics, tubulin post-translational modifications, microtubule motor proteins, nutrient deprivation, organelle degradation
- MeSH terms
- Animals, Autophagy, Humans, Lysosomes, Microtubules, Models, Biological, Phagocytosis, Protein Processing, Post-Translational, Tubulin
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