The DOI matches its Crossref record; 93 of the 93 references it cites were found in a registry or an index.
Tenascin-C at a glance
Abstract
Tenascin-C (TNC) is a hexameric, multimodular extracellular matrix protein with several molecular forms that are created through alternative splicing and protein modifications. It is highly conserved amongst vertebrates, and molecular phylogeny indicates that it evolved before fibronectin. Tenascin-C has many extracellular binding partners, including matrix components, soluble factors and pathogens; it also influences cell phenotype directly through interactions with cell surface receptors. Tenascin-C protein synthesis is tightly regulated, with widespread protein distribution in embryonic tissues, but restricted distribution of tenascin-C in adult tissues. Tenascin-C is also expressed de novo during wound healing or in pathological conditions, including chronic inflammation and cancer. First described as a modulator of cell adhesion, tenascin-C also directs a plethora of cell signaling and gene expression programs by shaping mechanical and biochemical cues within the cellular microenvironment. Exploitment of the pathological expression and function of tenascin-C is emerging as a promising strategy to develop new diagnostic, therapeutic and bioengineering tools. In this Cell Science at a Glance article and the accompanying poster we provide a succinct and comprehensive overview of the structural and functional features of tenascin-C and its potential roles in developing embryos and under pathological conditions.
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Cites
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Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs
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Self-citationTenascins: regulation and putative functions during pathological stress
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Self-citationGrowth Factors Engineered for Super-Affinity to the Extracellular Matrix Enhance Tissue Healing
Martino, M. M., Briquez, P. S., Güç, E., Tortelli, F., Kilarski, W. W., Metzger, S., Rice, J. J., Kuhn, G. A., Müller, R., Swartz, M. A., et al. (2014) · Science · doi:10.1126/science.1247663 · Cited by 498
The role of tenascin-C in tissue injury and tumorigenesis
Midwood, K. S., & Orend, G. (2009) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-009-0075-1 · Cited by 438
Self-citationChiquet, M., & Fambrough, D. M. (1984) · The Journal of cell biology · doi:10.1083/jcb.98.6.1926 · Cited by 432
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VEGF-A and Tenascin-C produced by S100A4 + stromal cells are important for metastatic colonization
O'Connell, J. T., Sugimoto, H., Cooke, V. G., MacDonald, B. A., Mehta, A. I., LeBleu, V. S., Dewar, R., Rocha, R. M., Brentani, R. R., Resnick, M. B., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109493108 · Cited by 348
Cited by
Extracellular matrix-based materials for regenerative medicine
Hussey, G. S., Dziki, J. L., & Badylak, S. F. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0023-x · Cited by 844
Adipokine dysregulation and adipose tissue inflammation in human obesity
Unamuno, X., Gómez‐Ambrosi, J., Rodríguez, A., Becerril, S., Frühbeck, G., & Catalán, V. (2018) · European Journal of Clinical Investigation · doi:10.1111/eci.12997 · Cited by 610
The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation
Moretti, L., Stalfort, J., Barker, T. H., & Abebayehu, D. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101530 · Cited by 393
Defining the Adult Neural Stem Cell Niche Proteome Identifies Key Regulators of Adult Neurogenesis
Kjell, J., Fischer-Sternjak, J., Thompson, A. J., Friess, C., Sticco, M. J., Salinas, F., Cox, J., Martinelli, D. C., Ninkovic, J., Franze, K., et al. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.01.002 · Cited by 163
Matrix molecules and skin biology
Nyström, A., & Bruckner-Tuderman, L. (2019) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2018.07.025 · Cited by 144
Metadata
- Authors
- Midwood, K. S., Chiquet, M., Tucker, R. P., & Orend, G.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2016-12-01
- Volume
- 129
- Issue
- 23
- Pages
- 4321-4327
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2551462252
- Cited by
- 429
- References
- 93
- FWCI
- 20.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- Midwood, K. S., Chiquet, M., Tucker, R. P., & Orend, G. (2016). Tenascin-C at a glance. Journal of Cell Science. https://doi.org/10.1242/jcs.190546
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