The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
New insights into autophagosome–lysosome fusion
Abstract
Macroautophagy (autophagy) is a highly conserved intracellular degradation system that is essential for homeostasis in eukaryotic cells. Due to the wide variety of the cytoplasmic targets of autophagy, its dysregulation is associated with many diseases in humans, such as neurodegenerative diseases, heart disease and cancer. During autophagy, cytoplasmic materials are sequestered by the autophagosome – a double-membraned structure – and transported to the lysosome for digestion. The specific stages of autophagy are induction, formation of the isolation membrane (phagophore), formation and maturation of the autophagosome and, finally, fusion with a late endosome or lysosome. Although there are significant insights into each of these steps, the mechanisms of autophagosome–lysosome fusion are least understood, although there have been several recent advances. In this Commentary, we will summarize the current knowledge regarding autophagosome–lysosome fusion, focusing on mammals, and discuss the remaining questions and future directions of the field.
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Cited by
Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion
Mauthe, M., Orhon, I., Rocchi, C., Zhou, X., Luhr, M., Hijlkema, K.-J., Coppes, R. P., Engedal, N., Mari, M., & Reggiori, F. (2018) · Autophagy · doi:10.1080/15548627.2018.1474314 · Cited by 2,122
Targeting Autophagy in Cancer: Recent Advances and Future Directions
Amaravadi, R. K., Kimmelman, A. C., & Debnath, J. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0292 · Cited by 928
Current understanding of osteoarthritis pathogenesis and relevant new approaches
Tong, L., Yu, H., Huang, X., Shen, J., Xiao, G., Chen, L., Wang, H., Xing, L., & Chen, D. (2022) · Bone Research · doi:10.1038/s41413-022-00226-9 · Cited by 437
Autophagy in liver diseases: Time for translation?
Allaire, M., Rautou, P.-E., Codogno, P., & Lotersztajn, S. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.01.026 · Cited by 378
The enigmatic endosome—sorting the ins and outs of endocytic trafficking
Naslavsky, N., & Caplan, S. (2018) · Journal of Cell Science · doi:10.1242/jcs.216499 · Cited by 353
Metadata
- Authors
- Nakamura, S., & Yoshimori, T.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2017-04-01
- Volume
- 130
- Issue
- 7
- Pages
- 1209-1216
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2597177247
- Cited by
- 518
- References
- 73
- FWCI
- 41.36
- Type
- journal article
- Language
- en
- Open access
- closed
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