CoChat
Sign Up
Cited by 353

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

The enigmatic endosome—sorting the ins and outs of endocytic trafficking

Naslavsky, Naava, Caplan, Steve·2018·Journal of Cell Science
DOI 10.1242/jcs.216499
Open this paper in CoChat — free account

Abstract

The early endosome (EE), also known as the sorting endosome (SE) is a crucial station for the sorting of cargoes, such as receptors and lipids, through the endocytic pathways. The term endosome relates to the receptacle-like nature of this organelle, to which endocytosed cargoes are funneled upon internalization from the plasma membrane. Having been delivered by the fusion of internalized vesicles with the EE or SE, cargo molecules are then sorted to a variety of endocytic pathways, including the endo-lysosomal pathway for degradation, direct or rapid recycling to the plasma membrane, and to a slower recycling pathway that involves a specialized form of endosome known as a recycling endosome (RE), often localized to the perinuclear endocytic recycling compartment (ERC). It is striking that ‘the endosome’, which plays such essential cellular roles, has managed to avoid a precise description, and its characteristics remain ambiguous and heterogeneous. Moreover, despite the rapid advances in scientific methodologies, including breakthroughs in light microscopy, overall, the endosome remains poorly defined. This Review will attempt to collate key characteristics of the different types of endosomes and provide a platform for discussion of this unique and fascinating collection of organelles. Moreover, under-developed, poorly understood and important open questions will be discussed.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1242/jcs.216499

Cites

13 of 13 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Receptor recycling from endosomes is a complex process that involves distinct pathways involving different adaptors, protein sorting machinery, and membrane composition.

    “Receptor recycling from endosomes is a complex process that involves distinct pathways involving different adaptors, protein sorting machinery, and membrane composition[23–25].”

    From Genome-scale CRISPR screening for modifiers of cellular LDL uptake (2021) · cites this paper as [24]

  • Early endocytic vesicles are slightly acidic at pH ~6.4, facilitating ligand/receptor dissociation, while lysosomes are highly acidic at pH 4-5, required for digestion of endocytosed biomolecules.

    “Early endocytic vesicles are slightly acidic (pH, ~6.4), which facilitates ligand/receptor dissociation. Lysosomes are highly acidic (pH 4–5), which is required for the digestion of endocytosed biomolecules (Figure 1A; Casey et al., 2010; Naslavsky and Caplan, 2018).”

    From NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load (2021) · cites this paper as Naslavsky and Caplan, 2018

  • Endocytic subcompartments become progressively more acidic, and their pH is regulated by vATPase proton pumps and NHE proton leakage channels.

    “Endocytic subcompartments become progressively more acidic, and the pH of these compartments is regulated by the opposing functions of vesicular ATP-dependent proton pumps (vATPase) and proton leakage channels (Na+/H+ exchangers, NHEs).”

    From NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load (2021) · cites this paper as Naslavsky and Caplan, 2018

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 196

  1. Allaire, 2013, Interplay between Rab35 and Arf6 controls cargo recycling to coordinate cell adhesion and migration, J. Cell Sci., 126, 722, 10.1242/jcs.112375 · DOI · Paper page
  2. Arighi, 2004, Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor, J. Cell Biol., 165, 123, 10.1083/jcb.200312055 · DOI · Paper page
  3. Babbey, 2006, Rab10 regulates membrane transport through early endosomes of polarized Madin-Darby canine kidney cells, Mol. Biol. Cell, 17, 3156, 10.1091/mbc.e05-08-0799 · DOI · Paper page
  4. Babst, 1997, Endosomal transport function in yeast requires a novel AAA-type ATPase, Vps4p, EMBO J., 16, 1820, 10.1093/emboj/16.8.1820 · DOI
  5. Babst, 2002, Endosome-associated complex, ESCRT-II, recruits transport machinery for protein sorting at the multivesicular body, Dev. Cell, 3, 283, 10.1016/S1534-5807(02)00219-8 · DOI
  6. Bache, 2003, STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes, J. Biol. Chem., 278, 12513, 10.1074/jbc.M210843200 · DOI · Paper page
  7. Bahl, 2016, EHD3 protein is required for tubular recycling endosome stabilization, and an asparagine-glutamic acid residue pair within its Eps15 homology (EH) domain dictates its selective binding to NPF peptides, J. Biol. Chem., 291, 13465, 10.1074/jbc.M116.716407 · DOI
  8. Balderhaar, 2013, CORVET and HOPS tethering complexes-coordinators of endosome and lysosome fusion, J. Cell Sci., 126, 1307, 10.1242/jcs.107805 · DOI
  9. Bananis, 2003, Regulation of early endocytic vesicle motility and fission in a reconstituted system, J. Cell Sci., 116, 2749, 10.1242/jcs.00478 · DOI
  10. Banta, 1990, Characterization of yeast Vps33p, a protein required for vacuolar protein sorting and vacuole biogenesis, Mol. Cell. Biol., 10, 4638, 10.1128/MCB.10.9.4638 · DOI
  11. Bennett, 1995, SNAREs and the specificity of transport vesicle targeting, Curr. Opin. Cell Biol., 7, 581, 10.1016/0955-0674(95)80016-6 · DOI
  12. Bilodeau, 2003, Vps27-Hse1 and ESCRT-I complexes cooperate to increase efficiency of sorting ubiquitinated proteins at the endosome, J. Cell Biol., 163, 237, 10.1083/jcb.200305007 · DOI
  13. Bissig, 2013, Lipid sorting and multivesicular endosome biogenesis, Cold Spring Harbor Perspect. Biol., 5, a016816, 10.1101/cshperspect.a016816 · DOI · Paper page
  14. Bonifacino, 2008, Retromer, Curr. Opin. Cell Biol., 20, 427, 10.1016/j.ceb.2008.03.009 · DOI · Paper page
  15. Braschi, 2010, Vps35 mediates vesicle transport between the mitochondria and peroxisomes, Curr. Biol., 20, 1310, 10.1016/j.cub.2010.05.066 · DOI
  16. Brotherus, 1977, Subcellular distributions of lipids in cultured BHK cells: evidence for the enrichment of lysobisphosphatidic acid and neutral lipids in lysosomes, J. Lipid Res., 18, 191, 10.1016/S0022-2275(20)41698-0 · DOI
  17. Cai, 2012, cPLA2alpha and EHD1 interact and regulate the vesiculation of cholesterol-rich, GPI-anchored, protein-containing endosomes, Mol. Biol. Cell, 23, 1874, 10.1091/mbc.e11-10-0881 · DOI · Paper page
  18. Cai, 2014, GRAF1 forms a complex with MICAL-L1 and EHD1 to cooperate in tubular recycling endosome vesiculation, Front. Cell Dev. Biol., 2, 22, 10.3389/fcell.2014.00022 · DOI · Paper page
  19. Caplan, 2001, Human Vam6p promotes lysosome clustering and fusion in vivo, J. Cell Biol., 154, 109, 10.1083/jcb.200102142 · DOI
  20. Caplan, 2002, A tubular EHD1-containing compartment involved in the recycling of major histocompatibility complex class I molecules to the plasma membrane, EMBO J., 21, 2557, 10.1093/emboj/21.11.2557 · DOI · Paper page
  21. Carson, 2013, The rab11 effector protein FIP1 regulates adiponectin trafficking and secretion, PLoS ONE, 8, e74687, 10.1371/journal.pone.0074687 · DOI
  22. Chen, 2001, SNARE-mediated membrane fusion, Nat. Rev. Mol. Cell Biol., 2, 98, 10.1038/35052017 · DOI
  23. Chen, 1996, The VPS8 gene is required for localization and trafficking of the CPY sorting receptor in Saccharomyces cerevisiae, Eur. J. Cell Biol., 70, 289
  24. Chen, 2013, Snx3 regulates recycling of the transferrin receptor and iron assimilation, Cell Metab., 17, 343, 10.1016/j.cmet.2013.01.013 · DOI · Paper page
  25. Chibalina, 2007, Myosin VI and its interacting protein LMTK2 regulate tubule formation and transport to the endocytic recycling compartment, J. Cell Sci., 120, 4278, 10.1242/jcs.014217 · DOI
  26. Christ, 2017, Cellular functions and molecular mechanisms of the ESCRT membrane-scission machinery, Trends Biochem. Sci., 42, 42, 10.1016/j.tibs.2016.08.016 · DOI
  27. Clague, 1995, Phosphatidylinositol 3-kinase regulation of fluid phase endocytosis, FEBS Lett., 367, 272, 10.1016/0014-5793(95)00576-U · DOI
  28. Clairfeuille, 2016, A molecular code for endosomal recycling of phosphorylated cargos by the SNX27-retromer complex, Nat. Struct. Mol. Biol., 23, 921, 10.1038/nsmb.3290 · DOI · Paper page
  29. Corvera, 1999, Phosphoinositides in membrane traffic, Curr. Opin. Cell Biol., 11, 460, 10.1016/S0955-0674(99)80066-0 · DOI
  30. Dai, 2004, ACAP1 promotes endocytic recycling by recognizing recycling sorting signals, Dev. Cell, 7, 771, 10.1016/j.devcel.2004.10.002 · DOI
  31. Daumke, 2007, Architectural and mechanistic insights into an EHD ATPase involved in membrane remodelling, Nature, 449, 923, 10.1038/nature06173 · DOI · Paper page
  32. de Duve, 2005, The lysosome turns fifty, Nat. Cell Biol., 7, 847, 10.1038/ncb0905-847 · DOI
  33. Delevoye, 2015, Rab GTPases and kinesin motors in endosomal trafficking, Methods Cell Biol., 130, 235, 10.1016/bs.mcb.2015.05.004 · DOI
  34. Delevoye, 2014, Recycling endosome tubule morphogenesis from sorting endosomes requires the kinesin motor KIF13A, Cell Rep., 6, 445, 10.1016/j.celrep.2014.01.002 · DOI
  35. Deutschlander, 2017, VPS35-Related Parkinson Disease
  36. Dharmalingam, 2009, F-BAR proteins of the syndapin family shape the plasma membrane and are crucial for neuromorphogenesis, J. Neurosci., 29, 13315, 10.1523/JNEUROSCI.3973-09.2009 · DOI
  37. Diaz, 1988, In vitro fusion of endosomes following receptor-mediated endocytosis, J. Biol. Chem., 263, 6093, 10.1016/S0021-9258(18)68754-X · DOI
  38. Donaldson, 2003, Multiple roles for Arf6: sorting, structuring, and signaling at the plasma membrane, J. Biol. Chem., 278, 41573, 10.1074/jbc.R300026200 · DOI
  39. Dyve, 2009, Sorting nexin 8 regulates endosome-to-Golgi transport, Biochem. Biophys. Res. Commun., 390, 109, 10.1016/j.bbrc.2009.09.076 · DOI
  40. Fárfan, 2013, A sorting nexin 17-binding domain within the LRP1 cytoplasmic tail mediates receptor recycling through the basolateral sorting endosome, Traffic, 14, 823, 10.1111/tra.12076 · DOI · Paper page
  41. Farmer, 2017, Control of mitochondrial homeostasis by endocytic regulatory proteins, J. Cell Sci., 130, 2359, 10.1242/jcs.204537 · DOI
  42. Farmer, 2018, Tying trafficking to fusion and fission at the mighty mitochondria, Traffic, doi:10.1111/tra.12573, 10.1111/tra.12573 · DOI
  43. Fasshauer, 2003, Structural insights into the SNARE mechanism, Biochim. Biophys. Acta, 1641, 87, 10.1016/S0167-4889(03)00090-9 · DOI
  44. Fasshauer, 1998, Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R-SNAREs, Proc. Natl. Acad. Sci. USA, 95, 15781, 10.1073/pnas.95.26.15781 · DOI
  45. Flinn, 2010, The late endosome is essential for mTORC1 signaling, Mol. Biol. Cell, 21, 833, 10.1091/mbc.e09-09-0756 · DOI
  46. Florian, 2001, A new member of the sorting nexin family interacts with the C-terminus of P-selectin, Biochem. Biophys. Res. Commun., 281, 1045, 10.1006/bbrc.2001.4467 · DOI · Paper page
  47. Follett, 2017, Retromer's role in endosomal trafficking and impaired function in neurodegenerative diseases, Curr. Protein Pept. Sci., 18, 687, 10.2174/1389203717666160311121246 · DOI
  48. Frankel, 2017, ESCRT-dependent cargo sorting at multivesicular endosomes, Semin. Cell Dev. Biol., 74, 4, 10.1016/j.semcdb.2017.08.020 · DOI
  49. Frankel, 2017, Ist1 regulates ESCRT-III assembly and function during multivesicular endosome biogenesis in Caenorhabditis elegans embryos, Nat. Commun., 8, 1439, 10.1038/s41467-017-01636-8 · DOI · Paper page
  50. Frederick, 2009, Bis(monoacylglycero)phosphate forms stable small lamellar vesicle structures: insights into vesicular body formation in endosomes, Biophys. J., 96, 1847, 10.1016/j.bpj.2008.12.3892 · DOI
  51. Gallon, 2014, A unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer, Proc. Natl. Acad. Sci. USA, 111, E3604, 10.1073/pnas.1410552111 · DOI · Paper page
  52. Ghai, 2013, Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins, Proc. Natl. Acad. Sci. USA, 110, E643, 10.1073/pnas.1216229110 · DOI · Paper page
  53. Gibbons, 1965, Dynein: a protein with adenosine triphosphatase activity from cilia, Science, 149, 424, 10.1126/science.149.3682.424 · DOI
  54. Giridharan, 2013, Cooperation of MICAL-L1, syndapin2, and phosphatidic acid in tubular recycling endosome biogenesis, Mol. Biol. Cell, 24, 1776, 10.1091/mbc.e13-01-0026 · DOI
  55. Gokool, 2007, EHD1 interacts with retromer to stabilize SNX1 tubules and facilitate endosome-to-Golgi retrieval, Traffic, 8, 1873, 10.1111/j.1600-0854.2007.00652.x · DOI · Paper page
  56. Gomez, 2009, A FAM21-containing WASH complex regulates retromer-dependent sorting, Dev. Cell, 17, 699, 10.1016/j.devcel.2009.09.009 · DOI · Paper page
  57. Gorvel, 1991, rab5 controls early endosome fusion in vitro, Cell, 64, 915, 10.1016/0092-8674(91)90316-Q · DOI
  58. Grant, 2009, Pathways and mechanisms of endocytic recycling, Nat. Rev. Mol. Cell Biol., 10, 597, 10.1038/nrm2755 · DOI · Paper page
  59. Grant, 2001, Evidence that RME-1, a conserved C. elegans EH-domain protein, functions in endocytic recycling, Nat. Cell Biol., 3, 573, 10.1038/35078549 · DOI
  60. Griffiths, 1989, The structure and function of a mannose 6-phosphate receptor-enriched, pre-lysosomal compartment in animal cells, J. Cell Sci. Suppl., 11, 139, 10.1242/jcs.1989.Supplement_11.11 · DOI
  61. Grosshans, 2006, Rabs and their effectors: achieving specificity in membrane traffic, Proc. Natl. Acad. Sci. USA, 103, 11821, 10.1073/pnas.0601617103 · DOI · Paper page
  62. Gruenberg, 1989, Characterization of the early endosome and putative endocytic carrier vesicles in vivo and with an assay of vesicle fusion in vitro, J. Cell Biol., 108, 1301, 10.1083/jcb.108.4.1301 · DOI
  63. Hales, 2002, Rab11 family interacting protein 2 associates with Myosin Vb and regulates plasma membrane recycling, J. Biol. Chem., 277, 50415, 10.1074/jbc.M209270200 · DOI
  64. Hanson, 2003, Evidence for a role of SNX16 in regulating traffic between the early and later endosomal compartments, J. Biol. Chem., 278, 34617, 10.1074/jbc.M300143200 · DOI
  65. Hanson, 2005, AAA+ proteins: have engine, will work, Nat. Rev. Mol. Cell Biol., 6, 519, 10.1038/nrm1684 · DOI
  66. Hanson, 1997, Structure and conformational changes in NSF and its membrane receptor complexes visualized by quick-freeze/deep-etch electron microscopy, Cell, 90, 523, 10.1016/S0092-8674(00)80512-7 · DOI
  67. Harbour, 2012, Recruitment of the endosomal WASH complex is mediated by the extended ‘tail’ of Fam21 binding to the retromer protein Vps35, Biochem. J., 442, 209, 10.1042/BJ20111761 · DOI · Paper page
  68. Harrison, 2014, A mechanism for retromer endosomal coat complex assembly with cargo, Proc. Natl. Acad. Sci. USA, 111, 267, 10.1073/pnas.1316482111 · DOI
  69. Hoepfner, 2005, Modulation of receptor recycling and degradation by the endosomal kinesin KIF16B, Cell, 121, 437, 10.1016/j.cell.2005.02.017 · DOI
  70. Holt, 2007, Assessment of myosin II, Va, VI and VIIa loss of function on endocytosis and endocytic vesicle motility in bone marrow-derived dendritic cells, Cell Motil. Cytoskeleton, 64, 756, 10.1002/cm.20220 · DOI
  71. Hopkins, 1983, Intracellular routing of transferrin and transferrin receptors in epidermoid carcinoma A431 cells, Cell, 35, 321, 10.1016/0092-8674(83)90235-0 · DOI
  72. Horazdovsky, 1993, The VPS16 gene product associates with a sedimentable protein complex and is essential for vacuolar protein sorting in yeast, J. Biol. Chem., 268, 4953, 10.1016/S0021-9258(18)53488-8 · DOI
  73. Hsu, 2018, Rab5 and Alsin regulate stress-activated cytoprotective signaling on mitochondria, Elife, 7, e32282, 10.7554/eLife.32282 · DOI
  74. Hsu, 2012, Getting active: protein sorting in endocytic recycling, Nat. Rev. Mol. Cell Biol., 13, 323, 10.1038/nrm3332 · DOI
  75. Hu, 2015, The endosomal-lysosomal system: from acidification and cargo sorting to neurodegeneration, Transl. Neurodegener, 4, 18, 10.1186/s40035-015-0041-1 · DOI
  76. Hullin-Matsuda, 2007, De novo biosynthesis of the late endosome lipid, bis(monoacylglycero)phosphate, J. Lipid Res., 48, 1997, 10.1194/jlr.M700154-JLR200 · DOI
  77. Jagath, 2004, Rab14 is involved in membrane trafficking between the Golgi complex and endosomes, Mol. Biol. Cell, 15, 2218, 10.1091/mbc.e03-10-0777 · DOI
  78. Jakobsson, 2011, Regulation of synaptic vesicle budding and dynamin function by an EHD ATPase, J. Neurosci., 31, 13972, 10.1523/JNEUROSCI.1289-11.2011 · DOI · Paper page
  79. Jia, 2010, WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes, Proc. Natl. Acad. Sci. USA, 107, 10442, 10.1073/pnas.0913293107 · DOI · Paper page
  80. Jia, 2012, Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer, Mol. Biol. Cell, 23, 2352, 10.1091/mbc.e11-12-1059 · DOI · Paper page
  81. Joensuu, 2017, Visualizing endocytic recycling and trafficking in live neurons by subdiffractional tracking of internalized molecules, Nat. Protoc., 12, 2590, 10.1038/nprot.2017.116 · DOI
  82. Jones, 1995, Phosphatidylinositol 3-kinase activity is required for early endosome fusion, Biochem. J., 311, 31, 10.1042/bj3110031 · DOI
  83. Jones, 2006, Endocytic recycling pathways: emerging regulators of cell migration, Curr. Opin. Cell Biol., 18, 549, 10.1016/j.ceb.2006.08.003 · DOI
  84. Joubert, 2004, New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting, J. Cell Sci., 117, 5367, 10.1242/jcs.01379 · DOI
  85. Jovic, 2010, The early endosome: a busy sorting station for proteins at the crossroads, Histol. Histopathol., 25, 99, 10.14670/HH-25.99 · DOI
  86. Kardon, 2009, Regulators of the cytoplasmic dynein motor, Nat. Rev. Mol. Cell Biol., 10, 854, 10.1038/nrm2804 · DOI
  87. Kauppi, 2002, The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking, J. Cell Sci., 115, 899, 10.1242/jcs.115.5.899 · DOI
  88. Khatter, 2015, Arf-like GTPase Arl8: moving from the periphery to the center of lysosomal biology, Cell Logist, 5, e1086501, 10.1080/21592799.2015.1086501 · DOI
  89. Kieken, 2007, EH domain of EHD1, J. Biomol. NMR, 39, 323, 10.1007/s10858-007-9196-0 · DOI
  90. Kieken, 2009, Structural insight into the interaction of proteins containing NPF, DPF, and GPF motifs with the C-terminal EH-domain of EHD1, Protein Sci., 18, 2471, 10.1002/pro.258 · DOI
  91. Kieken, 2010, Mechanism for the selective interaction of C-terminal Eps15 homology domain proteins with specific Asn-Pro-Phe-containing partners, J. Biol. Chem., 285, 8687, 10.1074/jbc.M109.045666 · DOI · Paper page
  92. Kobayashi, 1998, Lipids, lipid domains and lipid-protein interactions in endocytic membrane traffic, Semin. Cell Dev. Biol., 9, 517, 10.1006/scdb.1998.0257 · DOI
  93. Kobayashi, 1998, A lipid associated with the antiphospholipid syndrome regulates endosome structure and function, Nature, 392, 193, 10.1038/32440 · DOI · Paper page
  94. Komada, 1997, Hrs, a tyrosine kinase substrate with a conserved double zinc finger domain, is localized to the cytoplasmic surface of early endosomes, J. Biol. Chem., 272, 20538, 10.1074/jbc.272.33.20538 · DOI
  95. Kreykenbohm, 2002, The SNAREs vti1a and vti1b have distinct localization and SNARE complex partners, Eur. J. Cell Biol., 81, 273, 10.1078/0171-9335-00247 · DOI
  96. Kurten, 1996, Enhanced degradation of EGF receptors by a sorting nexin, SNX1, Science, 272, 1008, 10.1126/science.272.5264.1008 · DOI · Paper page
  97. Kutateladze, 2001, Structural mechanism of endosome docking by the FYVE domain, Science, 291, 1793, 10.1126/science.291.5509.1793 · DOI
  98. Lachmann, 2014, The Vps39-like TRAP1 is an effector of Rab5 and likely the missing Vps3 subunit of human CORVET, Cell Logist, 4, e970840, 10.4161/21592780.2014.970840 · DOI
  99. Lauffer, 2010, SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane, J. Cell Biol., 190, 565, 10.1083/jcb.201004060 · DOI · Paper page
  100. Lee, 2016, FAM21 directs SNX27-retromer cargoes to the plasma membrane by preventing transport to the Golgi apparatus, Nat. Commun., 7, 10939, 10.1038/ncomms10939 · DOI · Paper page
  101. Li, 1995, Evidence for phosphatidylinositol 3-kinase as a regulator of endocytosis via activation of Rab5, Proc. Natl. Acad. Sci. USA, 92, 10207, 10.1073/pnas.92.22.10207 · DOI
  102. Lin, 1997, Structural organization of the synaptic exocytosis core complex, Neuron, 19, 1087, 10.1016/S0896-6273(00)80399-2 · DOI
  103. Lippé, 2001, Functional synergy between Rab5 effector Rabaptin-5 and exchange factor Rabex-5 when physically associated in a complex, Mol. Biol. Cell, 12, 2219, 10.1091/mbc.12.7.2219 · DOI
  104. Liu, 2012, Rab GTPase regulation of retromer-mediated cargo export during endosome maturation, Mol. Biol. Cell, 23, 2505, 10.1091/mbc.e11-11-0915 · DOI
  105. Loubery, 2008, Different microtubule motors move early and late endocytic compartments, Traffic, 9, 492, 10.1111/j.1600-0854.2008.00704.x · DOI · Paper page
  106. Lu, 2015, Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation, Nat. Cell Biol., 17, 228, 10.1038/ncb3109 · DOI · Paper page
  107. Magadan, 2006, Rab22a regulates the sorting of transferrin to recycling endosomes, Mol. Cell. Biol., 26, 2595, 10.1128/MCB.26.7.2595-2614.2006 · DOI
  108. Matsushita, 2004, A novel kinesin-like protein, KIF1Bbeta3 is involved in the movement of lysosomes to the cell periphery in non-neuronal cells, Traffic, 5, 140, 10.1111/j.1600-0854.2003.00165.x · DOI
  109. Maxfield, 2004, Endocytic recycling, Nat. Rev. Mol. Cell Biol., 5, 121, 10.1038/nrm1315 · DOI · Paper page
  110. McKenzie, 2012, Retromer guides STxB and CD8-M6PR from early to recycling endosomes, EHD1 guides STxB from recycling endosome to Golgi, Traffic, 13, 1140, 10.1111/j.1600-0854.2012.01374.x · DOI
  111. Mesa, 2001, Rab22a affects the morphology and function of the endocytic pathway, J. Cell Sci., 114, 4041, 10.1242/jcs.114.22.4041 · DOI
  112. Miaczynska, 2004, APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment, Cell, 116, 445, 10.1016/S0092-8674(04)00117-5 · DOI
  113. Morel, 2009, Annexin A2-dependent polymerization of actin mediates endosome biogenesis, Dev. Cell, 16, 445, 10.1016/j.devcel.2009.01.007 · DOI
  114. Murphy, 1984, Endosome pH measured in single cells by dual fluorescence flow cytometry: rapid acidification of insulin to pH 6, J. Cell Biol., 98, 1757, 10.1083/jcb.98.5.1757 · DOI
  115. Nakamura, 2017, New insights into autophagosome-lysosome fusion, J. Cell Sci., 130, 1209, 10.1242/jcs.196352 · DOI
  116. Nakamura, 1997, Vam2/Vps41p and Vam6/Vps39p are components of a protein complex on the vacuolar membranes and involved in the vacuolar assembly in the yeast Saccharomyces cerevisiae, J. Biol. Chem., 272, 11344, 10.1074/jbc.272.17.11344 · DOI
  117. Naslavsky, 2005, C-terminal EH-domain-containing proteins: consensus for a role in endocytic trafficking, EH?, J. Cell Sci., 118, 4093, 10.1242/jcs.02595 · DOI · Paper page
  118. Naslavsky, 2011, EHD proteins: key conductors of endocytic transport, Trends Cell Biol., 21, 122, 10.1016/j.tcb.2010.10.003 · DOI · Paper page
  119. Naslavsky, 2004, Rabenosyn-5 and EHD1 interact and sequentially regulate protein recycling to the plasma membrane, Mol. Biol. Cell, 15, 2410, 10.1091/mbc.e03-10-0733 · DOI
  120. Naslavsky, 2006, Interactions between EHD proteins and Rab11-FIP2: a role for EHD3 in early endosomal transport, Mol. Biol. Cell, 17, 163, 10.1091/mbc.e05-05-0466 · DOI · Paper page
  121. Naslavsky, 2003, Convergence of non-clathrin- and clathrin-derived endosomes involves Arf6 inactivation and changes in phosphoinositides, Mol. Biol. Cell, 14, 417, 10.1091/mbc.02-04-0053 · DOI
  122. Navaroli, 2012, Rabenosyn-5 defines the fate of the transferrin receptor following clathrin-mediated endocytosis, Proc. Natl. Acad. Sci. USA, 109, E471, 10.1073/pnas.1115495109 · DOI
  123. Nielsen, 2000, Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain, J. Cell Biol., 151, 601, 10.1083/jcb.151.3.601 · DOI
  124. Noda, 1995, KIF2 is a new microtubule-based anterograde motor that transports membranous organelles distinct from those carried by kinesin heavy chain or KIF3A/B, J. Cell Biol., 129, 157, 10.1083/jcb.129.1.157 · DOI
  125. Oestreich, 2007, Mvb12 is a novel member of ESCRT-I involved in cargo selection by the multivesicular body pathway, Mol. Biol. Cell, 18, 646, 10.1091/mbc.e06-07-0601 · DOI
  126. Otsuki, 1999, SNX5, a new member of the sorting nexin family, binds to the Fanconi anemia complementation group A protein, Biochem. Biophys. Res. Commun., 265, 630, 10.1006/bbrc.1999.1731 · DOI · Paper page
  127. Pal, 2006, Huntingtin-HAP40 complex is a novel Rab5 effector that regulates early endosome motility and is up-regulated in Huntington's disease, J. Cell Biol., 172, 605, 10.1083/jcb.200509091 · DOI
  128. Parks, 2001, Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases, J. Biol. Chem., 276, 19332, 10.1074/jbc.M100606200 · DOI · Paper page
  129. Pasqualato, 2004, The structural GDP/GTP cycle of Rab11 reveals a novel interface involved in the dynamics of recycling endosomes, J. Biol. Chem., 279, 11480, 10.1074/jbc.M310558200 · DOI
  130. Pfeffer, 2017, Rab GTPases: master regulators that establish the secretory and endocytic pathways, Mol. Biol. Cell, 28, 712, 10.1091/mbc.e16-10-0737 · DOI
  131. Phillips, 2001, Identification and characterization of SNX15, a novel sorting nexin involved in protein trafficking, J. Biol. Chem., 276, 5074, 10.1074/jbc.M004671200 · DOI · Paper page
  132. Phillips-Krawczak, 2015, COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A, Mol. Biol. Cell, 26, 91, 10.1091/mbc.e14-06-1073 · DOI · Paper page
  133. Piper, 1995, VPS27 controls vacuolar and endocytic traffic through a prevacuolar compartment in Saccharomyces cerevisiae, J. Cell Biol., 131, 603, 10.1083/jcb.131.3.603 · DOI
  134. Pons, 2008, Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies, PLoS Biol., 6, e214, 10.1371/journal.pbio.0060214 · DOI
  135. Pons, 2012, SNX12 role in endosome membrane transport, PLoS ONE, 7, e38949, 10.1371/journal.pone.0038949 · DOI · Paper page
  136. Poteryaev, 2010, Identification of the switch in early-to-late endosome transition, Cell, 141, 497, 10.1016/j.cell.2010.03.011 · DOI · Paper page
  137. Prekeris, 1998, Syntaxin 13 mediates cycling of plasma membrane proteins via tubulovesicular recycling endosomes, J. Cell Biol., 143, 957, 10.1083/jcb.143.4.957 · DOI · Paper page
  138. Pu, 2016, Mechanisms and functions of lysosome positioning, J. Cell Sci., 129, 4329, 10.1242/jcs.196287 · DOI · Paper page
  139. Rahajeng, 2010, Collapsin response mediator protein-2 (Crmp2) regulates trafficking by linking endocytic regulatory proteins to dynein motors, J. Biol. Chem., 285, 31918, 10.1074/jbc.C110.166066 · DOI
  140. Rahajeng, 2012, MICAL-L1 is a tubular endosomal membrane hub that connects Rab35 and Arf6 with Rab8a, Traffic, 13, 82, 10.1111/j.1600-0854.2011.01294.x · DOI · Paper page
  141. Ren, 1998, Hydrolysis of GTP on rab11 is required for the direct delivery of transferrin from the pericentriolar recycling compartment to the cell surface but not from sorting endosomes, Proc. Natl. Acad. Sci. USA, 95, 6187, 10.1073/pnas.95.11.6187 · DOI · Paper page
  142. Rincón, 2007, Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase roles in endocytic recycling, Mol. Cell. Proteomics, 6, 1073, 10.1074/mcp.M700047-MCP200 · DOI
  143. Rink, 2005, Rab conversion as a mechanism of progression from early to late endosomes, Cell, 122, 735, 10.1016/j.cell.2005.06.043 · DOI
  144. Robinson, 1991, A putative zinc finger protein, Saccharomyces cerevisiae Vps18p, affects late Golgi functions required for vacuolar protein sorting and efficient alpha-factor prohormone maturation, Mol. Cell. Biol., 11, 5813, 10.1128/MCB.11.12.5813 · DOI
  145. Roland, 2007, Myosin Vb interacts with Rab8a on a tubular network containing EHD1 and EHD3, Mol. Biol. Cell, 18, 2828, 10.1091/mbc.e07-02-0169 · DOI
  146. Salas-Cortes, 2005, Myosin Ib modulates the morphology and the protein transport within multi-vesicular sorting endosomes, J. Cell Sci., 118, 4823, 10.1242/jcs.02607 · DOI
  147. Santama, 1998, KIF2beta, a new kinesin superfamily protein in non-neuronal cells, is associated with lysosomes and may be implicated in their centrifugal translocation, EMBO J., 17, 5855, 10.1093/emboj/17.20.5855 · DOI
  148. Schindler, 2015, EARP is a multisubunit tethering complex involved in endocytic recycling, Nat. Cell Biol., 17, 639, 10.1038/ncb3129 · DOI
  149. Schmidt, 2009, Regulation of endosomal membrane traffic by a Gadkin/AP-1/kinesin KIF5 complex, Proc. Natl. Acad. Sci. USA, 106, 15344, 10.1073/pnas.0904268106 · DOI
  150. Schnatwinkel, 2004, The Rab5 effector Rabankyrin-5 regulates and coordinates different endocytic mechanisms, PLoS Biol., 2, E261, 10.1371/journal.pbio.0020261 · DOI
  151. Schonteich, 2008, The Rip11/Rab11-FIP5 and kinesin II complex regulates endocytic protein recycling, J. Cell Sci., 121, 3824, 10.1242/jcs.032441 · DOI
  152. Scott, 2014, Endosome maturation, transport and functions, Semin. Cell Dev. Biol., 31, 2, 10.1016/j.semcdb.2014.03.034 · DOI
  153. Seaman, 2004, Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer, J. Cell Biol., 165, 111, 10.1083/jcb.200312034 · DOI · Paper page
  154. Seaman, 2002, Identification of the functional domains of yeast sorting nexins Vps5p and Vps17p, Mol. Biol. Cell, 13, 2826, 10.1091/mbc.02-05-0064 · DOI · Paper page
  155. Seaman, 2013, Retromer-mediated endosomal protein sorting: all WASHed up!, Trends Cell Biol., 23, 522, 10.1016/j.tcb.2013.04.010 · DOI
  156. Seaman, 1998, A membrane coat complex essential for endosome-to-Golgi retrograde transport in yeast, J. Cell Biol., 142, 665, 10.1083/jcb.142.3.665 · DOI · Paper page
  157. Sharma, 2008, A role for EHD4 in the regulation of early endosomal transport, Traffic, 9, 995, 10.1111/j.1600-0854.2008.00732.x · DOI · Paper page
  158. Sharma, 2009, MICAL-L1 links EHD1 to tubular recycling endosomes and regulates receptor recycling, Mol. Biol. Cell, 20, 5181, 10.1091/mbc.e09-06-0535 · DOI · Paper page
  159. Sharma, 2010, MICAL-L1: An unusual Rab effector that links EHD1 to tubular recycling endosomes, Commun. Integr. Biol., 3, 181, 10.4161/cib.3.2.10845 · DOI
  160. Shaw, 2003, PtdIns(3,5)P2 is required for delivery of endocytic cargo into the multivesicular body, Traffic, 4, 479, 10.1034/j.1600-0854.2003.t01-1-00106.x · DOI
  161. Shi, 2010, EHBP-1 functions with RAB-10 during endocytic recycling in Caenorhabditis elegans, Mol. Biol. Cell, 21, 2930, 10.1091/mbc.e10-02-0149 · DOI · Paper page
  162. Simonsen, 1998, EEA1 links PI(3)K function to Rab5 regulation of endosome fusion, Nature, 394, 494, 10.1038/28879 · DOI · Paper page
  163. Simonsen, 1999, The Rab5 effector EEA1 interacts directly with syntaxin-6, J. Biol. Chem., 274, 28857, 10.1074/jbc.274.41.28857 · DOI
  164. Simpson, 2004, A role for the small GTPase Rab21 in the early endocytic pathway, J. Cell Sci., 117, 6297, 10.1242/jcs.01560 · DOI
  165. Söllner, 1995, SNAREs and targeted membrane fusion, FEBS Lett., 369, 80, 10.1016/0014-5793(95)00594-Y · DOI
  166. Sönnichsen, 2000, Distinct membrane domains on endosomes in the recycling pathway visualized by multicolor imaging of Rab4, Rab5, and Rab11, J. Cell Biol., 149, 901, 10.1083/jcb.149.4.901 · DOI · Paper page
  167. Stefani, 2011, UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sorting, Curr. Biol., 21, 1245, 10.1016/j.cub.2011.06.028 · DOI
  168. Steinberg, 2012, SNX17 protects integrins from degradation by sorting between lysosomal and recycling pathways, J. Cell Biol., 197, 219, 10.1083/jcb.201111121 · DOI · Paper page
  169. Steinberg, 2013, A global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal ion transport, Nat. Cell Biol., 15, 461, 10.1038/ncb2721 · DOI · Paper page
  170. Stenmark, 1995, Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion, Cell, 83, 423, 10.1016/0092-8674(95)90120-5 · DOI
  171. Stenmark, 2002, The phosphatidylinositol 3-phosphate-binding FYVE finger, FEBS Lett., 513, 77, 10.1016/S0014-5793(01)03308-7 · DOI · Paper page
  172. Stuchell-Brereton, 2007, ESCRT-III recognition by VPS4 ATPases, Nature, 449, 740, 10.1038/nature06172 · DOI
  173. Szymanska, 2017, Endosomal “sort” of signaling control: the role of ESCRT machinery in regulation of receptor-mediated signaling pathways, Semin. Cell Dev. Biol., 74, 11, 10.1016/j.semcdb.2017.08.012 · DOI
  174. Tang, 2015, VPS35 deficiency or mutation causes dopaminergic neuronal loss by impairing mitochondrial fusion and function, Cell Rep., 12, 1631, 10.1016/j.celrep.2015.08.001 · DOI
  175. Teasdale, 2001, A large family of endosome-localized proteins related to sorting nexin 1, Biochem. J., 358, 7, 10.1042/bj3580007 · DOI
  176. Temkin, 2011, SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors, Nat. Cell Biol., 13, 715, 10.1038/ncb2252 · DOI · Paper page
  177. Traer, 2007, SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment, Nat. Cell Biol., 9, 1370, 10.1038/ncb1656 · DOI · Paper page
  178. Tran, 2007, VAMP4 cycles from the cell surface to the trans-Golgi network via sorting and recycling endosomes, J. Cell Sci., 120, 1028, 10.1242/jcs.03387 · DOI
  179. Ullrich, 1996, Rab11 regulates recycling through the pericentriolar recycling endosome, J. Cell Biol., 135, 913, 10.1083/jcb.135.4.913 · DOI · Paper page
  180. Van Der Sluijs, 1991, The small GTP-binding protein rab4 is associated with early endosomes, Proc. Natl. Acad. Sci. USA, 88, 6313, 10.1073/pnas.88.14.6313 · DOI
  181. van Weering, 2014, Membrane-associated cargo recycling by tubule-based endosomal sorting, Semin. Cell Dev. Biol., 31, 40, 10.1016/j.semcdb.2014.03.015 · DOI
  182. Vilariño-Güell, 2011, VPS35 mutations in Parkinson disease, Am. J. Hum. Genet., 89, 162, 10.1016/j.ajhg.2011.06.001 · DOI · Paper page
  183. Wang, 2016, Parkinson's disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes, Nat. Med., 22, 54, 10.1038/nm.3983 · DOI
  184. Wang, 2017, SNARE proteins in membrane trafficking, Traffic, 18, 767, 10.1111/tra.12524 · DOI
  185. Wang, 2018, Endosomal receptor trafficking: retromer and beyond, Traffic, doi:10.1111/tra.12574, 10.1111/tra.12574 · DOI
  186. Weigert, 2004, Rab22a regulates the recycling of membrane proteins internalized independently of clathrin, Mol. Biol. Cell, 15, 3758, 10.1091/mbc.e04-04-0342 · DOI
  187. Xie, 2015, The endocytic recycling compartment maintains cargo segregation acquired upon exit from the sorting endosome, Mol. Biol. Cell, 27, 108, 10.1091/mbc.e15-07-0514 · DOI
  188. Xu, 2001, SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P, Nat. Cell Biol., 3, 658, 10.1038/35083051 · DOI
  189. Yoshida, 2017, Segregation of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate into distinct microdomains on the endosome membrane, Biochim. Biophys. Acta, 1859, 1880, 10.1016/j.bbamem.2017.06.014 · DOI
  190. Zeng, 1999, Identification of a putative effector protein for rab11 that participates in transferrin recycling, Proc. Natl. Acad. Sci. USA, 96, 2840, 10.1073/pnas.96.6.2840 · DOI
  191. Zeng, 2003, The cytoplasmic domain of Vamp4 and Vamp5 is responsible for their correct subcellular targeting: the N-terminal extenSion of VAMP4 contains a dominant autonomous targeting signal for the trans-Golgi network, J. Biol. Chem., 278, 23046, 10.1074/jbc.M303214200 · DOI
  192. Zhang, 2012, EHDs meet the retromer: complex regulation of retrograde transport, Cell Logist, 2, 161, 10.4161/cl.20582 · DOI
  193. Zhang, 2012, Rabankyrin-5 interacts with EHD1 and Vps26 to regulate endocytic trafficking and retromer function, Traffic, 13, 745, 10.1111/j.1600-0854.2012.01334.x · DOI · Paper page
  194. Zimprich, 2011, A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease, Am. J. Hum. Genet., 89, 168, 10.1016/j.ajhg.2011.06.008 · DOI · Paper page
  195. Zuk, 1999, Rab15 mediates an early endocytic event in Chinese hamster ovary cells, J. Biol. Chem., 274, 22303, 10.1074/jbc.274.32.22303 · DOI
  196. Zuk, 2000, Rab15 differentially regulates early endocytic trafficking, J. Biol. Chem., 275, 26754, 10.1074/jbc.M000344200 · DOI

Cited by

Sorted by citations

Metadata

Authors
Naslavsky, N., & Caplan, S.
Affiliations
The University of Nebraska Medical Center 1 The Department of Biochemistry and Molecular Biology , , Omaha, NE 68198 , USA
ORCID
Caplan, Steve
Venue
Journal of Cell Science
Publisher
The Company of Biologists
Published
2018-07-01
Volume
131
Issue
13
ISSN
  • 1477-9137
  • 0021-9533
DOI
10.1242/jcs.216499
Cited by
353
References
13
Language
en
Licence
www.biologists.com/user-licence-1-1 (vor, 184 d)
Funders
National Institutes of General Medical Sciences (1R01GM123557-01A1)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review