The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Evolution of the coordinate regulation of glycolytic enzyme genes by hypoxia
Abstract
SUMMARY: Two billion years of aerobic evolution have resulted in mammalian cells and tissues that are extremely oxygen-dependent. Exposure to oxygen tensions outside the relatively narrow physiological range results in cellular stress and toxicity. Consequently, hypoxia features prominently in many human diseases, particularly those associated with blood and vascular disorders,including all forms of anemia and ischemia. Bioenergetic enzymes have evolved both acute and chronic oxygen sensing mechanisms to buffer changes of oxygen tension; at normal PO oxidative phosphorylation is the principal energy supply for eukaryotic cells, but when the PO falls below a critical mark metabolic switches turn off mitochondrial electron transport and activate anaerobic glycolysis. Without this switch cells would suffer an immediate energy deficit and death at low PO. An intriguing feature of the switching is that the same conditions that regulate energy metabolism also regulate bioenergetic genes, so that enzyme activity and transcription are regulated simultaneously,albeit with different time courses and signaling pathways. In this review we explore the pathways mediating hypoxia-regulated glycolytic enzyme gene expression, focusing on their atavistic traits and evolution.
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Cellular and developmental control of O 2 homeostasis by hypoxia-inducible factor 1α
Iyer, N. V., Kotch, L. E., Agani, F., Leung, S. W., Laughner, E., Wenger, R. H., Gassmann, M., Gearhart, J. D., Lawler, A. M., Yu, A. Y., et al. (1998) · Genes & Development · doi:10.1101/gad.12.2.149 · Cited by 2,476
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Mechanism, origin, and evolution of anoxia tolerance in animals☆
Hochachka, P. W., & Lutz, P. L. (2001) · Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology · doi:10.1016/s1096-4959(01)00408-0 · Cited by 500
Precambrian Sponges with Cellular Structures
Li, C.-W., Chen, J.-Y., & Hua, T.-E. (1998) · Science · doi:10.1126/science.279.5352.879 · Cited by 489
Molecular Regulation of the Endothelin-1 Gene by Hypoxia
Yamashita, K., Discher, D. J., Hu, J., Bishopric, N. H., & Webster, K. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011344200 · Cited by 340
Self-citationJiang, Y., Vasconcelles, M. J., Wretzel, S., Light, A., Martin, C. E., & Goldberg, M. A. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.18.6161-6169.2001 · Cited by 95
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Metadata
- Authors
- Webster, K. A.
- Venue
- Journal of Experimental Biology
- Publisher
- The Company of Biologists
- Published
- 2003-09-01
- Volume
- 206
- Issue
- 17
- Pages
- 2911-2922
- ISSN
- 0022-0949 (ISSN-L)
- 1477-9145
- OpenAlex
- W2051088765
- Cited by
- 189
- References
- 7
- FWCI
- 2.66
- Type
- journal article
- Language
- en
- Open access
- closed
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