Mitochondria: diversity in the regulation of the NLRP3 inflammasome

Gurung, Prajwal; Lukens, John R.; Kanneganti, Thirumala-Devi

doi:10.1016/j.molmed.2014.11.008

Cited by 393Inflammasome and immune disordersImmune Response and InflammationCell death mechanisms and regulation

Mitochondria: diversity in the regulation of the NLRP3 inflammasome

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Gurung, Prajwal, Lukens, John R., Kanneganti, Thirumala-Devi·2015·Trends in Molecular Medicine

DOI 10.1016/j.molmed.2014.11.008PMC PMC4352396

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Abstract

Recent studies have identified new roles for mitochondria in the regulation of autoinflammatory processes. Emerging data suggests that the release of danger signals from mitochondria in response to stress and infection promotes the formation of the inflammatory signaling platform known as inflammasomes. Activation of inflammasomes by damaged mitochondria results in caspase-1-dependent secretion of the inflammatory cytokines interleukin-1β (IL-1β) and IL-18, and an inflammatory form of cell death referred to as pyroptosis. Here, we review recently described mechanisms that have been proposed to be involved in mitochondria-mediated regulation of inflammasome activation and inflammation. In addition, we highlight how aberrant regulation of mitochondria-induced inflammasome activation centrally contributes to the inflammatory process that is responsible for obesity and associated metabolic diseases.

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Mitochondria is a central regulator of NLRP3 inflammasome activation through ROS, Ca2+, decrease of NAD+, Mfn or mitochondrial DNA.
“In fact, mitochondria is considered a central regulator of NLRP3 inflammasome activation through ROS, Ca 2+ , decrease of NAD + , Mfn or mitochondrial DNA (Gurung et al., 2015).”
From Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity (2017) · cites this paper as Gurung et al., 2015
The release of danger signals from mitochondria promotes the formation of inflammasomes.
“The release of danger signals from mitochondria promotes the formation of inflammasomes. In fact, mitochondria is considered a central regulator of NLRP3 inflammasome activation through ROS, Ca 2+ , decrease of NAD + , Mfn or mitochondrial DNA (Gurung et al., 2015).”
From Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity (2017) · cites this paper as Gurung et al., 2015
Mitochondria are a central regulator of NLRP3 inflammasome activation through ROS, Ca2+, decrease of NAD+, Mfn or mitochondrial DNA.
“mitochondria is considered a central regulator of NLRP3 inflammasome activation through ROS, Ca 2+ , decrease of NAD + , Mfn or mitochondrial DNA (Gurung et al., 2015).”
From Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity (2017) · cites this paper as Gurung et al., 2015

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894 · see citing works
A role for mitochondria in nlrp3 inflammasome activation
Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602 · see citing works
Inflammation and insulin resistance
Shoelson, S. E. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29069 · Cited by 4,769 · see citing works
The BCL-2 protein family: opposing activities that mediate cell death
Youle, R. J., & Strasser, A. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2308 · Cited by 4,704 · see citing works
Guidelines for the use and interpretation of assays for monitoring autophagy
Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., et al. (2012) · Autophagy · doi:10.4161/auto.19496 · Cited by 3,996 · cited 8× · see citing works
“NOD2/RIPK2-dependent mitophagy and LC3B/Beclin 1-mediated autophagy are involved in the clearance of damaged mitochondria, and thus negatively regulate NLRP3 inflammasome activation.”
BackgroundInfluential
Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death
Wei, M. C., Zong, W.-X., Cheng, E. H.-Y., Lindsten, T., Panoutsakopoulou, V., Ross, A. J., Roth, K. A., MacGregor, G. R., Thompson, C. B., & Korsmeyer, S. J. (2001) · Science · doi:10.1126/science.1059108 · Cited by 3,988 · see citing works
Circulating mitochondrial DAMPs cause inflammatory responses to injury
Zhang, Q., Raoof, M., Chen, Y., Sumi, Y., Sursal, T., Junger, W., Brohi, K., Itagaki, K., & Hauser, C. J. (2010) · Nature · doi:10.1038/nature08780 · Cited by 3,812 · see citing works
Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3
Seth, R. B., Sun, L., Ea, C.-K., & Chen, Z. J. (2005) · Cell · doi:10.1016/j.cell.2005.08.012 · Cited by 3,329 · see citing works
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology · doi:10.1038/ni.1980 · Cited by 3,049 · see citing works
Thioredoxin-interacting protein links oxidative stress to inflammasome activation
Zhou, R., Tardivel, A., Thorens, B., Choi, I., & Tschopp, J. (2010) · Nature Immunology · doi:10.1038/ni.1831 · Cited by 2,708 · see citing works
Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica
Dostert, C., Pétrilli, V., Van Bruggen, R., Steele, C., Mossman, B. T., & Tschopp, J. (2008) · Science · doi:10.1126/science.1156995 · Cited by 2,658 · see citing works
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
Vandanmagsar, B., Youm, Y.-H., Ravussin, A., Galgani, J. E., Stadler, K., Mynatt, R. L., Ravussin, E., Stephens, J. M., & Dixit, V. D. (2011) · Nature Medicine · doi:10.1038/nm.2279 · Cited by 2,655 · see citing works
Caspase Functions in Cell Death and DiseasePreprint
McIlwain, D. R., Berger, T., & Mak, T. W. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008656 · Cited by 2,607 · see citing works
Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development
Chen, H., Detmer, S. A., Ewald, A. J., Griffin, E. E., Fraser, S. E., & Chan, D. C. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200211046 · Cited by 2,601 · see citing works
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
Kawai, T., Takahashi, K., Sato, S., Coban, C., Kumar, H., Kato, H., Ishii, K. J., Takeuchi, O., & Akira, S. (2005) · Nature Immunology · doi:10.1038/ni1243 · Cited by 2,562 · see citing works
Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes
Kelley, D. E., He, J., Menshikova, E. V., & Ritov, V. B. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2944 · Cited by 2,321 · see citing works
Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
Shimada, K., Crother, T. R., Karlin, J., Dagvadorj, J., Chiba, N., Chen, S., Ramanujan, V. K., Wolf, A. J., Vergnes, L., Ojcius, D. M., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.009 · Cited by 2,282 · see citing works
Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes
Petersen, K. F., Dufour, S., Befroy, D., Garcia, R., & Shulman, G. I. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031314 · Cited by 2,193 · see citing works
K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter
Muñoz-Planillo, R., Kuffa, P., Martínez-Colón, G. J., Smith, B. L., Rajendiran, T. M., & Núñez, G. (2013) · Immunity · doi:10.1016/j.immuni.2013.05.016 · Cited by 2,167 · see citing works
Mitochondrial dysfunction and type 2 diabetes
Lowell, B. B., & Shulman, G. I. (2005) · Science · doi:10.1126/science.1104343 · Cited by 2,070 · see citing works
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production
Saitoh, T., Fujita, N., Jang, M. H., Uematsu, S., Yang, B., Satoh, T., Omori, H., Noda, T., Yamamoto, N., Komatsu, M., et al. (2008) · Nature · doi:10.1038/nature07383 · Cited by 2,020 · see citing works
The Role of Mitochondria in Apoptosis
Wang, C., & Youle, R. J. (2009) · Annual Review of Genetics · doi:10.1146/annurev-genet-102108-134850 · Cited by 1,987 · see citing works
VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling
Xu, L., Wang, Y., Han, K.-J., Li, L., Zhai, Z., & Shu, H. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.08.014 · Cited by 1,849 · see citing works
Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling
Wen, H., Gris, D., Lei, Y. L., Jha, S., Zhang, L., Huang, M. T.-H., Brickey, W. J., & Ting, J. P. ‐. (2011) · Nature Immunology · doi:10.1038/ni.2022 · Cited by 1,811 · see citing works
Interleukin-1-receptor antagonist in type 2 diabetes mellitus
Larsen, C. M., Faulenbach, M., Vaag, A., Vølund, A., Ehses, J. A., Seifert, B., Mandrup-Poulsen, T., & Donath, M. Y. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa065213 · Cited by 1,798 · see citing works
The Combined Functions of Proapoptotic Bcl-2 Family Members Bak and Bax Are Essential for Normal Development of Multiple Tissues
Lindsten, T., Ross, A. J., King, A., Zong, W.-X., Rathmell, J. C., Shiels, H. A., Ulrich, E., Waymire, K. G., Mahar, P., Frauwirth, K., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00136-2 · Cited by 1,489 · see citing works
Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration
Pétrilli, V, Papin, S., Dostert, C., Mayor, A., Martinon, F., & Tschopp, J. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402195 · Cited by 1,445 · see citing works
Mitochondrial Complex I Inhibitor Rotenone Induces Apoptosis through Enhancing Mitochondrial Reactive Oxygen Species Production
Li, N., Ragheb, K., Lawler, G., Sturgis, J., Rajwa, B. P., Melendez, J. A., & Robinson, J. P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210432200 · Cited by 1,434 · see citing works
Disruption of Fusion Results in Mitochondrial Heterogeneity and Dysfunction
Chen, H., Chomyn, A., & Chan, D. C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503062200 · Cited by 1,376 · cited 2× · see citing works
“Mice lacking either mitofusin 1 or mitofusin 2 are embryonic lethal, demonstrating the critical roles played by these proteins in vivo [51, 52].”
Background
The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses
Rathinam, V. A. K., Jiang, Z., Waggoner, S. N., Sharma, S., Cole, L. E., Waggoner, L., Vanaja, S. K., Monks, B. G., Ganesan, S., Latz, E., et al. (2010) · Nature Immunology · doi:10.1038/ni.1864 · Cited by 1,331 · see citing works
MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response
Hou, F., Sun, L., Zheng, H., Skaug, B. A., Jiang, Q., & Chen, Z. J. (2011) · Cell · doi:10.1016/j.cell.2011.06.041 · Cited by 1,274 · see citing works
Mitochondria
Newmeyer, D. D., & Ferguson-Miller, S. M. (2003) · Cell · doi:10.1016/s0092-8674(03)00116-8 · Cited by 1,268 · see citing works
tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome cPreprint
Wei, M. C., Lindsten, T., Mootha, V. K., Weiler, S., Gross, A., Ashiya, M., Thompson, C. B., & Korsmeyer, S. J. (2000) · Genes & Development · doi:10.1101/gad.14.16.2060 · Cited by 1,265 · see citing works
Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3
Kanneganti, T., Özören, N., Body–Malapel, M., Amer, A. O., Park, J., Franchi, L., Whitfield, J. R., Barchet, W., Colonna, M., Vandenabeele, P., et al. (2006) · Nature · doi:10.1038/nature04517 · Cited by 1,149 · see citing works
Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells
Chu, C. T., Ji, J., Dagda, R. K., Jiang, J. F., Tyurina, Y. Y., Kapralov, A. A., Tyurin, V. A., Yanamala, N., Shrivastava, I. H., Mohammadyani, D., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2837 · Cited by 1,083 · see citing works
The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP
Lee, G., Subramanian, N., Kim, A. I., Aksentijevich, I. A., Goldbach‐Mansky, R. T., Sacks, D. B., Germain, R. N., Kastner, D. L., & Chae, J. J. (2012) · Nature · doi:10.1038/nature11588 · Cited by 1,077 · see citing works
NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation
Cooney, R. M., BAKER, J. T., Brain, O., Danis, B., Pichulik, T., Allan, P., Ferguson, D. J. P., Campbell, B. J., Jewell, D. P., & Simmons, A. (2009) · Nature Medicine · doi:10.1038/nm.2069 · Cited by 1,046 · see citing works
The P2X7 Receptor: A Key Player in IL-1 Processing and Release
Ferrari, D., Pizzirani, C., Adinolfi, E., Lemoli, R. M., Curti, A., Idzko, M., Panther, E., & Di Virgilio, F. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.7.3877 · Cited by 1,025 · see citing works
Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation
Iyer, S. S., He, Q., Janczy, J. R., Elliott, E. I., Zhong, Z., Olivier, A. K., Sadler, J. J., Knepper-Adrian, V., Han, R., Qiao, L., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.001 · Cited by 939 · see citing works
Critical role for calcium mobilization in activation of the NLRP3 inflammasome
Murakami, T., Öckinger, J., Yu, J., Byles, V., McColl, A., Hofer, A. M., & Horng, T. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117765109 · Cited by 926 · see citing works
Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome
Misawa, T., Takahama, M., Kozaki, T., Lee, H., Zou, J., Saitoh, T., & Akira, S. (2013) · Nature Immunology · doi:10.1038/ni.2550 · Cited by 863 · see citing works
Glyburide inhibits the Cryopyrin/Nalp3 inflammasome
Lamkanfi, M., Mueller, J. L., Vitari, A. C., Misaghi, S., Fedorova, A., Deshayes, K., Lee, W. P., Hoffman, H. M., & Dixit, V. M. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200903124 · Cited by 820 · see citing works
ATP Activates a Reactive Oxygen Species-dependent Oxidative Stress Response and Secretion of Proinflammatory Cytokines in Macrophages
Cruz, C. M., Rinna, A., Forman, H. J., Ventura, A. L. M., Persechini, P. M., & Ojcius, D. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608083200 · Cited by 786 · see citing works
Citric Acid Cycle and Role of its Intermediates in Metabolism
Akram, M. (2013) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-013-9750-1 · Cited by 743 · see citing works
The AIM2 inflammasome is critical for innate immunity to Francisella tularensis
Fernandes-Alnemri, T., Yu, J.-W., Juliana, C., Solorzano, L., Kang, S., Wu, J., Datta, P., McCormick, M., Huang, L., McDermott, E., et al. (2010) · Nature Immunology · doi:10.1038/ni.1859 · Cited by 732 · see citing works
Inflammasome is a central player in the induction of obesity and insulin resistance
Stienstra, R., van Diepen, J. A., Tack, C. J., Zaki, M. H., van de Veerdonk, F. L., Perera, D., Neale, G. A., Hooiveld, G. J., Hijmans, A., Vroegrijk, I., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100255108 · Cited by 727 · see citing works
Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency
López-Lluch, G., Hunt, N., Jones, B., Zhu, M., Jamieson, H., Hilmer, S., Cascajo, M. V., Allard, J., Ingram, D. K., Navas, P., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510452103 · Cited by 699 · see citing works
The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity
Stienstra, R., Joosten, L. A. B., Koenen, T. B., van Tits, B. L. J. H., van Diepen, J. A., van den Berg, S. A. A., Rensen, P. C. N., Voshol, P. J., Fantuzzi, G., Hijmans, A., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.11.011 · Cited by 681 · see citing works
The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation
Subramanian, N., Natarajan, K., Clatworthy, M. R., Wang, Z., & Germain, R. N. (2013) · Cell · doi:10.1016/j.cell.2013.02.054 · Cited by 675 · see citing works
The ADP and ATP transport in mitochondria and its carrier
Klingenberg, M. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.04.011 · Cited by 613 · see citing works
Mitochondrial respiration is decreased in skeletal muscle of patients with type 2 diabetes
Mogensen, M., Sahlin, K., Fernström, M., Glintborg, D., Vind, B. F., Beck-Nielsen, H., & Højlund, K. (2007) · Diabetes · doi:10.2337/db06-0981 · Cited by 573 · see citing works
FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes
Gurung, P., Anand, P., Malireddi, R. K. S., Walle, L. V., Opdenbosch, N. V., Dillon, C. P., Weinlich, R., Green, D. R., Lamkanfi, M., & Kanneganti, T. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302839 · Cited by 558 · see citing works
The Inflammasome Mediates UVB-Induced Activation and Secretion of Interleukin-1β by Keratinocytes
Feldmeyer, L., Keller, M., Niklaus, G., Hohl, D., Werner, S., & Beer, H.-D. (2007) · Current Biology · doi:10.1016/j.cub.2007.05.074 · Cited by 544 · see citing works
Mitochondrial Regulation of Cell Death
Tait, S. W. G., & Green, D. R. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008706 · Cited by 530 · see citing works
Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors
Rossol, M., Pierer, M., Raulien, N., Quandt, D., Meusch, U., Rothe, K., Schubert, K. A., Schöneberg, T., Schaefer, M., Krügel, U., et al. (2012) · Nature Communications · doi:10.1038/ncomms2339 · Cited by 487 · see citing works
Endosymbiotic theory for organelle origins
Zimorski, V., Ku, C., Martin, W. F., & Gould, S. B. (2014) · Current Opinion in Microbiology · doi:10.1016/j.mib.2014.09.008 · Cited by 453 · see citing works
Receptor interacting protein kinase 2–mediated mitophagy regulates inflammasome activation during virus infection
Lupfer, C., Thomas, P. G., Anand, P. K., Vogel, P., Milasta, S., Martinez, J., Huang, G., Green, M., Kundu, M., Chi, H., et al. (2013) · Nature Immunology · doi:10.1038/ni.2563 · Cited by 384 · see citing works
Bcl-2 inhibits Bax translocation from cytosol to mitochondria during drug-induced apoptosis of human tumor cells
Murphy, K. M., Ranganathan, V., Farnsworth, M. L., Kavallaris, M., & Lock, R. B. (2000) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400597 · Cited by 356 · see citing works
Caspase-independent cell death: leaving the set without the final cut
Tait, S. W. G., & Green, D. R. (2008) · Oncogene · doi:10.1038/onc.2008.311 · Cited by 353 · see citing works
An NLRP7-Containing Inflammasome Mediates Recognition of Microbial Lipopeptides in Human Macrophages
Khare, S., Dorfleutner, A., Bryan, N. B., Yun, C., Radian, A. D., de Almeida, L., Rojanasakul, Y., & Stehlik, C. (2012) · Immunity · doi:10.1016/j.immuni.2012.02.001 · Cited by 340 · see citing works
Human astrocytes express a novel NLRP2 inflammasome
Minkiewicz, J., Vaccari, J. P. D. R., & Keane, R. W. (2013) · Glia · doi:10.1002/glia.22499 · Cited by 328 · see citing works
Long-term treatment with interleukin-1β induces insulin resistance in murine and human adipocytes
Lagathu, C., Yvan‐Charvet, L., Bastard, J., Maachi, M., Quignard‐Boulangé, A., Capeau, J., & Caron, M. (2006) · Diabetologia · doi:10.1007/s00125-006-0335-z · Cited by 323 · see citing works
Binding of the Respiratory Chain Inhibitor Antimycin to the Mitochondrial bc1 Complex: A New Crystal Structure Reveals an Altered Intramolecular Hydrogen-bonding Pattern
Huang, L.-S., Cobessi, D., Tung, E. Y., & Berry, E. A. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.05.053 · Cited by 304 · see citing works
Mitochondrial protein mitofusin 2 is required for NLRP3 inflammasome activation after RNA virus infection
Ichinohe, T., Yamazaki, T., Koshiba, T., & Yanagi, Y. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312571110 · Cited by 284 · see citing works
The Mitochondrial Antiviral Protein MAVS Associates with NLRP3 and Regulates Its Inflammasome Activity
Park, S., Juliana, C. A., Hong, S., Datta, P., Hwang, I., Fernandes‐Alnemri, T., Yu, J., & Alnemri, E. S. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301170 · Cited by 266 · see citing works
Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non‐apoptotic caspase‐8 is required for inflammasome priming
Allam, R., Lawlor, K. E., Yu, E. C.-W., Mildenhall, A., Moujalled, D. M., Lewis, R. S., Ke, F., Mason, K. D., White, M. J., Stacey, K. J., et al. (2014) · EMBO Reports · doi:10.15252/embr.201438463 · Cited by 238 · see citing works
Hsp90-Cdc37 Chaperone Complex Regulates Ulk1- and Atg13-Mediated Mitophagy
Joo, J. H., Dorsey, F. C., Joshi, A., Hennessy-Walters, K. M., Rose, K. L., McCastlain, K., Zhang, J., Iyengar, R. V., Jung, C. H., Suen, D., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.06.018 · Cited by 236 · see citing works
Chronic Caloric Restriction Preserves Mitochondrial Function in Senescence without Increasing Mitochondrial Biogenesis
Lanza, I. R., Zabielski, P., Klaus, K. A., Morse, D. M., Heppelmann, C. J., Bergen, H. R., Dasari, S., Walrand, S., Short, K. R., Johnson, M. L., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.11.003 · Cited by 227 · see citing works
Adipocyte Mitochondrial Function Is Reduced in Human Obesity Independent of Fat Cell Size
Yin, X. L., Lanza, I. R., Swain, J. M., Sarr, M. G., Nair, K. S., & Jensen, M. D. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3042 · Cited by 226 · see citing works
Symbiosis and Evolution
Margulis, L. (1971) · Scientific American · doi:10.1038/scientificamerican0871-48 · Cited by 200 · see citing works
Evolution of the coordinate regulation of glycolytic enzyme genes by hypoxia
Webster, K. A. (2003) · Journal of Experimental Biology · doi:10.1242/jeb.00516 · Cited by 189 · see citing works
Cytosolic Double-Stranded RNA Activates the NLRP3 Inflammasome via MAVS-Induced Membrane Permeabilization and K+ Efflux
Franchi, L., Eigenbrod, T., Muñoz-Planillo, R., Ozkurede, U., Kim, Y., Chakrabarti, A., Gale, M., Silverman, R. H., Colonna, M., Akira, S., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400582 · Cited by 183 · see citing works
Novel Roles for Caspase-8 in IL-1β and Inflammasome Regulation
Gurung, P., & Kanneganti, T. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.08.025 · Cited by 178 · see citing works
Ca2+ Stores and Ca2+ Entry Differentially Contribute to the Release of IL-1β and IL-1α from Murine Macrophages
Brough, D., Feuvre, R. A. L., Wheeler, R. D., Solovyova, N. A., Hilfiker, S., Rothwell, N. J., & Verkhratsky, A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.6.3029 · Cited by 168 · see citing works
Cholesterol-dependent cytolysins induce rapid release of mature IL-1β from murine macrophages in a NLRP3 inflammasome and cathepsin B-dependent manner
Chu, J., Thomas, L. M., Watkins, S. C., Franchi, L., Núñez, G., & Salter, R. D. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0309164 · Cited by 142 · see citing works
Regulation of skeletal muscle mitochondrial fatty acid metabolism in lean and obese individuals
Holloway, G. P., Bonen, A., & Spriet, L. L. (2008) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26717b · Cited by 140 · see citing works
Cardiolipin binding in bacterial respiratory complexes: Structural and functional implications
Arias-Cartin, R., Grimaldi, S., Arnoux, P., Guigliarelli, B., & Magalon, A. (2012) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2012.04.005 · Cited by 117 · see citing works
Proinflammatory cytokines differentially regulate adipocyte mitochondrial metabolism, oxidative stress, and dynamics
Hahn, W. S., Kuzmicic, J., Burrill, J. S., Donoghue, M. A., Foncea, R. E., Jensen, M. D., Lavandero, S., Arriaga, E. A., & Bernlohr, D. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00422.2013 · Cited by 114 · see citing works
Role of the Nlrp3 Inflammasome in Microbial Infection
Anand, P., Malireddi, R. K. S., & Kanneganti, T. (2011) · Frontiers in Microbiology · doi:10.3389/fmicb.2011.00012 · Cited by 104 · see citing works
Mycobacterium abscessus activates the NLRP3 inflammasome via Dectin‐1–Syk and p62/SQSTM1
Lee, H., Yuk, J., Kim, K., Jang, J., Kang, G., Park, J. B., Son, J. W., & Jo, E. (2011) · Immunology and Cell Biology · doi:10.1038/icb.2011.72 · Cited by 90 · see citing works
The role of weight loss and exercise in correcting skeletal muscle mitochondrial abnormalities in obesity, diabetes and aging
Toledo, F. G. S., & Goodpaster, B. H. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.06.018 · Cited by 82 · see citing works
Inflammasome activation in obesity-related inflammatory diseases and autoimmunity.
Lukens, J. R., Dixit, V. D., & Kanneganti, T. (2011) · PubMed · Cited by 78 · see citing works
Mitochondrial Ca 2+ sequestration and precipitation revisited
Chinopoulos, C., & Ádám‐Vizi, V. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07755.x · Cited by 75 · see citing works
Consequences of the combined loss of BOK and BAK or BOK and BAX
Ke, F., Bouillet, P., Kaufmann, T., Strasser, A., Kerr, J., & Voss, A. K. (2013) · Cell Death & Disease · doi:10.1038/cddis.2013.176 · Cited by 72 · see citing works
Cardiolipin deficiency leads to decreased cardiolipin peroxidation and increased resistance of cells to apoptosis
Huang, Z., Jiang, J., Tyurin, V. A., Zhao, Q., Mnuskin, A., Ren, J., Belikova, N. A., Feng, W., Kurnikov, I. V., & Kagan, V. E. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.02.016 · Cited by 68 · see citing works
Release of mitochondrial DNA fragments from brain mitochondria of irradiated mice
Patrushev, M., Kasymov, V., Patrusheva, V., Ushakova, T., Gogvadze, V., & Gaziev, A. I. (2006) · Mitochondrion · doi:10.1016/j.mito.2005.12.001 · Cited by 59 · see citing works
The role of inflammasome modulation in virulence
Lupfer, C. R., & Kanneganti, T. (2012) · Virulence · doi:10.4161/viru.20266 · Cited by 43 · see citing works
Protection of Cytochrome c Oxidase against Cyanide Inhibition by Pyruvate and α-Ketoglutarate: Effect of Aeration in Vitro
Delhumeau, G., Cruzmendoza, A. M., & Lojero, C. G. (1994) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1994.1125 · Cited by 35 · see citing works
Insulin Resistance and Impaired Mitochondrial Function in Obese Adolescent Girls
Slattery, M. J., Bredella, M. A., Thakur, H., Torriani, M., & Misra, M. (2013) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2013.0100 · Cited by 21 · see citing works

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[37]Chinopoulos C Adam-Vizi V Mitochondrial Ca2+ sequestration and precipitation revisited The FEBS journal 2010 277 18 3637 51 20659160
[59]Nakahira K Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome Nat Immunol 2011 12 3 222 30 21151103 PMC3079381

Sorted by citations

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Dunn, J. D., Álvarez, L., Zhang, X., & Soldati, T. (2015) · Redox Biology · doi:10.1016/j.redox.2015.09.005 · Cited by 1,199 · see citing works
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Rovira‐Llopis, S., Apostolova, N., Bañuls, C., Muntané, J., Rocha, M., & Víctor, V. M. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7313 · Cited by 120 · see citing works
The Mitochondrial Phosphatase PGAM5 Is Dispensable for Necroptosis but Promotes Inflammasome Activation in Macrophages
Moriwaki, K., Farias Luz, N., Balaji, S., De Rosa, M. J., O’Donnell, C. L., Gough, P. J., Bertin, J., Welsh, R. M., & Chan, F. K.-M. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501662 · Cited by 116 · see citing works
Age-associated changes in human CD4+ T cells point to mitochondrial dysfunction consequent to impaired autophagy
Bektas, A., Schurman, S. H., Gonzalez-Freire, M., Dunn, C. A., Singh, A. K., Macian, F., Cuervo, A. M., Sen, R., & Ferrucci, L. (2019) · Aging · doi:10.18632/aging.102438 · Cited by 116 · see citing works
Silybin inhibits NLRP3 inflammasome assembly through the NAD + /SIRT2 pathway in mice with nonalcoholic fatty liver disease
Zhang, B., Xu, D., She, L., Wang, Z., Yang, N., Sun, R., Zhang, Y., Yan, C., Wei, Q., Aa, J., et al. (2017) · The FASEB Journal · doi:10.1096/fj.201700602r · Cited by 112 · see citing works
The Multifaceted Regulation of Mitochondria in Ferroptosis
Wu, H., Wang, F., Ta, N., Zhang, T., & Gao, W. (2021) · Life · doi:10.3390/life11030222 · Cited by 111 · see citing works
Inflammatory Signaling and Brown Fat Activity
Omran, F., & Christian, M. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00156 · Cited by 107 · see citing works
Mitochondrial regulation of cell death: a phylogenetically conserved control
Galluzzi, L., Kepp, O., & Kroemer, G. (2016) · Microbial Cell · doi:10.15698/mic2016.03.483 · Cited by 106 · see citing works
Progress in Nonalcoholic Fatty Liver Disease: SIRT Family Regulates Mitochondrial Biogenesis
Zeng, C., & Chen, M. (2022) · Biomolecules · doi:10.3390/biom12081079 · Cited by 108 · see citing works
Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity
López-Lluch, G. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.12.005 · Cited by 103 · see citing works
“In several of the models studied including rodents and humans, these diseases are associated with mitochondrial dysfunction indicated by low expression of mtDNA and reduction of the levels of proteins involved in oxidative phosphorylation (OXPHOS).”
BackgroundInfluential
Hepatitis B virus X protein promotes liver cell pyroptosis under oxidative stress through NLRP3 inflammasome activation
Xie, W., Ding, J. D., Xiao-xia, X., Yang, X., Wu, X., Chen, Z., Guo, Q., Gao, W., Wang, X., & Li, D. (2020) · Inflammation Research · doi:10.1007/s00011-020-01351-z · Cited by 103 · see citing works
Lipids, inflammasomes, metabolism, and disease
Anand, P. (2020) · Immunological Reviews · doi:10.1111/imr.12891 · Cited by 104 · see citing works
Mitochondrial Control of Innate Immunity and Inflammation
Jin, H. S., Suh, H., Kim, S., & Jo, E. (2017) · Immune Network · doi:10.4110/in.2017.17.2.77 · Cited by 101 · see citing works
GSDMD-mediated pyroptosis: a critical mechanism of diabetic nephropathy
Zuo, Y., Chen, L., Gu, H., He, X., Ye, Z., Wang, Z., Shao, Q., & Xue, C. (2021) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2021.27 · Cited by 100 · see citing works
Mitochondria-Derived Damage-Associated Molecular Patterns in Neurodegeneration
Wilkins, H. M., Weidling, I. W., Ji, Y., & Swerdlow, R. H. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00508 · Cited by 102 · see citing works
FABP4/aP2 Regulates Macrophage Redox Signaling and Inflammasome Activation via Control of UCP2
Steen, K. A., Xu, H., & Bernlohr, D. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00282-16 · Cited by 94 · see citing works
NLRP3 Inflammasome Activation: A Therapeutic Target for Cerebral Ischemia–Reperfusion Injury
Wang, L., Ren, W., Wu, Q., Liu, T., Wei, Y. L., Ding, J., Zhou, C., Xu, H., & Yang, S. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.847440 · Cited by 100 · see citing works
Recent advances in the NEK7-licensed NLRP3 inflammasome activation: Mechanisms, role in diseases and related inhibitors
Zhao, N., Li, C.-C., Di, B., & Xu, L.-L. (2020) · Journal of Autoimmunity · doi:10.1016/j.jaut.2020.102515 · Cited by 103 · see citing works
Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation
de la Roche, M., Hamilton, C., Mortensen, R., Jeyaprakash, A. A., Ghosh, S., & Anand, P. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201709057 · Cited by 97 · see citing works
Pinocembrin ameliorates intermittent hypoxia-induced neuroinflammation through BNIP3-dependent mitophagy in a murine model of sleep apnea
Gong, L., Wang, X., Gu, W., & Wu, X. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-02014-w · Cited by 96 · see citing works
Dietary PUFAs attenuate NLRP3 inflammasome activation via enhancing macrophage autophagy
Shen, L., Yang, Y., Ou, T., Key, C.-C. C., Tong, S. H., Sequeira, R. C., Nelson, J. M., Nie, Y., Wang, Z., Boudyguina, E. Y., et al. (2017) · Journal of Lipid Research · doi:10.1194/jlr.m075879 · Cited by 95 · see citing works
SIRT3 deficiency-induced mitochondrial dysfunction and inflammasome formation in the brain
Tyagi, A., Nguyen, C. U., Chong, T., Michel, C. R., Fritz, K. S., Reisdorph, N. A., Knaub, L. A., Reusch, J. E. B., & Pugazhenthi, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-35890-7 · Cited by 96 · see citing works
Ruptured abdominal aortic aneurysm—epidemiology, predisposing factors, and biology
Schmitz‐Rixen, T., Keese, M. A., Hakimi, M., Peters, A. S., Böckler, D., Nelson, K., & Grundmann, R. T. (2016) · Langenbeck s Archives of Surgery · doi:10.1007/s00423-016-1401-8 · Cited by 95 · see citing works
Is Alzheimer’s disease an inflammasomopathy?
Pereira, C., Santos, A. E., Moreira, P. I., Pereira, A. C., Sousa, F. J., Cardoso, S. M., & Cruz, M. T. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100966 · Cited by 94 · see citing works
FGF21 mitigates atherosclerosis via inhibition of NLRP3 inflammasome-mediated vascular endothelial cells pyroptosis
Zeng, Z., Zheng, Q., Chen, J., Tan, X., Li, Q., Ding, L., Zhang, R., & Lin, X. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.112108 · Cited by 94 · see citing works
SIRT1-Rab7 axis attenuates NLRP3 and STING activation through late endosomal-dependent mitophagy during sepsis-induced acute lung injury
Jiang, T., Liu, E., Li, Z., Yan, C., Zhang, X., Guan, J., Zhan, Y., Zhao, B., & Ding, W. (2024) · International Journal of Surgery · doi:10.1097/js9.0000000000001215 · Cited by 94 · see citing works
Important roles of linoleic acid and α-linolenic acid in regulating cognitive impairment and neuropsychiatric issues in metabolic-related dementia
Kim, O. Y., & Song, J. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122356 · Cited by 96 · see citing works
Mitochondria and Aging—The Role of Exercise as a Countermeasure
Nilsson, M. I., & Tarnopolsky, M. A. (2019) · Biology · doi:10.3390/biology8020040 · Cited by 92 · see citing works
The APPL1-Rab5 axis restricts NLRP3 inflammasome activation through early endosomal-dependent mitophagy in macrophages
Wu, K. K. L., Long, K., Lin, H., Siu, P. M., Hoo, R. L. C., Ye, D., Xu, A., & Cheng, K. K. Y. (2021) · Nature Communications · doi:10.1038/s41467-021-26987-1 · Cited by 93 · see citing works
NLRP3 Inflammasome: The Stormy Link Between Obesity and COVID-19
López-Reyes, A. G., Martínez-Armenta, C., Espinosa-Velázquez, R., Vázquez-Cárdenas, P., Cruz‐Ramos, M., Palacios‐González, B., Gómez-Quiroz, L. E., & Martínez‐Nava, G. A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.570251 · Cited by 90 · see citing works
Mitochondria as Molecular Platforms Integrating Multiple Innate Immune Signalings
Monlun, M., Hyernard, C., Blanco, P., Lartigue, L., & Faustin, B. (2016) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.10.028 · Cited by 85 · see citing works
Activation of Pyroptotic Cell Death Pathways in Cancer: An Alternative Therapeutic Approach
Kanipandian, N., Kannan, S., Thorne, R. F., Li, D., & Li, D. (2019) · Translational Oncology · doi:10.1016/j.tranon.2019.04.010 · Cited by 87 · see citing works
Advances in the molecular mechanisms of NLRP3 inflammasome activators and inactivators
Liu, D., Zeng, X., Li, X., Cui, C., Hou, R., Guo, Z., Mehta, J. L., & Wang, X. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.113863 · Cited by 87 · see citing works
Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation
Torres-Odio, S., Key, J., Hoepken, H.-H., Canet-Pons, J., Valek, L., Roller, B., Walter, M. J., Morales-Gordo, B., Meierhofer, D., Harter, P. N., et al. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0928-0 · Cited by 85 · see citing works
Mitochondrial Oxidative Stress in Brain Microvascular Endothelial Cells: Triggering Blood-Brain Barrier Disruption.
Wang, Y., Wu, J., Wang, J.-X., He, L.-X., Lai, H., Zhang, T., Wang, X., & Li, W. (2023) · Mitochondrion (Amsterdam. Print) · doi:10.1016/j.mito.2023.01.007 · Cited by 80 · see citing works

Authors: Gurung, P., Lukens, J. R., & Kanneganti, T.-D.
Affiliations: St. Jude Children's Research Hospital (US)
ORCID: Gurung, Prajwal
Lukens, John R.
Kanneganti, Thirumala-Devi
Venue: Trends in Molecular Medicine
Publisher: Elsevier BV
Published: 2015-03
Volume: 21
Issue: 3
Pages: 193-201
ISSN: 1471-4914 (ISSN-L)
DOI: 10.1016/j.molmed.2014.11.008
PMC: PMC4352396
OpenAlex: W1999224782
Cited by: 393
References: 89
Citations by year: 2026: 19 · 2025: 26 · 2024: 32 · 2023: 37 · 2022: 28 · 2021: 45 · 2020: 57 · 2019: 37 · 2018: 32 · 2017: 32 · 2016: 33 · 2015: 14 · 2013: 1
FWCI: 2.48
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Molecular Medicine (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: American Lebanese Syrian Associated Charities
National Institutes of Health
National Cancer Institute (R01CA163507, CA163507)
National Institute of Allergy and Infectious Diseases (AI101935, R01AI101935, R37AI101935)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR056296, AR-056296)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: mitochondria, NLRP3 inflammasome, inflammasome activation, autoinflammation, caspase-1, IL-1β, IL-18, pyroptosis, mitochondrial damage, mitochondrial stress, obesity, metabolic inflammation
MeSH terms: Carrier Proteins, Humans, Mitochondria, Models, Biological, Obesity, Reactive Oxygen Species, Inflammasomes

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Mitochondria: diversity in the regulation of the NLRP3 inflammasome

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