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The Dh gene of Drosophila melanogaster encodes a diuretic peptide that acts through cyclic AMP
Abstract
SUMMARY: Dh, the gene that encodes a CRF-like peptide in Drosophila melanogaster, is described. The product of this gene is a 44-amino-acid peptide (Drome-DH44) with a sequence almost identical to the Musca domestica and Stomoxys calcitrans diuretic hormones. There are no other similar peptides encoded within the known Drosophila genomic sequence. Functional studies showed that the deduced peptide stimulated fluid production, and that this effect was mediated by cyclic AMP in principal cells only: there was no effect on the levels of either cyclic GMP or intracellular calcium. Stimulation also elevated levels of cyclic AMP (but not cyclic GMP) phosphodiesterase, a new mode of action for this class of hormone. The transcript was localised by in situhybridisation, and the peptide by immunocytochemistry, to two groups of three neurones in the pars intercerebralis within the brain. These cells also express receptors for leucokinin, another major diuretic peptide, implying that the cells may be important in homeostatic regulation.
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Cited by
Recent advances in neuropeptide signaling in Drosophila, from genes to physiology and behavior
Nässel, D. R., & Zandawala, M. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.02.003 · Cited by 355
Kapan, N., Lushchak, O. V., Luo, J., & Nässel, D. R. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1097-z · Cited by 169
Denholm (2013) · doi:10.4161/org.24107 · Cited by 48
Nässel, D. R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041940 · Cited by 42
Sukumar, S. K., Antonydhason, V., Molander, L., Sandakly, J., Umapathy, G., Mendoza-Garcia, P., Masudi, T., Schlossser, A., Nässel, D. R., Wegener, C., et al. (2023) · doi:10.7554/elife.88985.1 · Cited by 1
Metadata
- Authors
- Cabrero, P., Radford, J. C., Broderick, K. E., Costes, L., Veenstra, J. A., Spana, E. P., Davies, S. A., & Dow, J. A. T.
- Venue
- Journal of Experimental Biology
- Publisher
- The Company of Biologists
- Published
- 2002-12-15
- Volume
- 205
- Issue
- 24
- Pages
- 3799-3807
- ISSN
- 0022-0949 (ISSN-L)
- 1477-9145
- OpenAlex
- W2153327500
- Cited by
- 168
- References
- 0
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cabrero, P., Radford, J. C., Broderick, K. E., Costes, L., Veenstra, J. A., Spana, E. P., Davies, S. A., & Dow, J. A. T. (2002). The Dh gene of Drosophila melanogaster encodes a diuretic peptide that acts through cyclic AMP. Journal of Experimental Biology. https://doi.org/10.1242/jeb.205.24.3799
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