Pain palliation in patients with bone metastases using MR-guided focused ultrasound surgery: a multicenter study
Abstract
Background Noninvasive thermal ablation using magnetic resonance (MR)-guided focused ultrasound (MRgFUS) has been shown to be clinically effective in uterine fibroids, and is being evaluated for ablation of breast, liver, and brain lesions. Recently MRgFUS has been evaluated for palliation of pain caused by bone metastases. We present the clinical results of a multicenter study using MRgFUS for palliation of bone metastases pain.Methods A multicenter study to evaluate the safety and efficacy of MRgFUS palliative treatment of bone metastases was conducted in patients suffering from painful metastatic bone lesions for which other treatments were either ineffective or not feasible. Thirty-one patients with painful bone metastases underwent the MRgFUS procedure in three medical centers. Treatment safety was evaluated by assessing the device-related complications. Effectiveness of pain palliation was evaluated using the visual analog pain score (VAS), and measurable changes in the intake of opioid analgesics.Results Thirty-six procedures were performed on 31 patients. Mean follow-up time was 4 months. 25 patients underwent the planned treatment and were available for 3 months post-treatment follow-up. 72% of the patients (18/25) reported significant pain improvement. Average VAS score was reduced from 5.9 prior to treatment to 1.8 at 3 months post treatment. 67% of patients with recorded medication data reported a reduction in their opioid usage. No device-related severe adverse events were recorded.Conclusion The results suggest that MRgFUS has the ability to provide an accurate, effective, and safe noninvasive palliative treatment for patients with bone metastases.
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Patients treated with HIFU showed marked reductions in opioid intake after sonication of painful lesions.
“patients treated with HIFU also evidenced marked reductions in opioid intake following the sonication of painful lesions [63].”
Cites
Cancer: Principles and Practice of Oncology.
(1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-114-9-819_4 · Cited by 8,524 · see citing works
Farrar, J. T., Young, J. P., LaMoreaux, L., Werth, J. L., & Poole, M. R. (2001) · Pain · doi:10.1016/s0304-3959(01)00349-9 · Cited by 5,808 · see citing works
Metastasis to bone: causes, consequences and therapeutic opportunities
Mundy, G. R. (2002) · Nature reviews. Cancer · doi:10.1038/nrc867 · Cited by 2,787 · see citing works
Roodman, G. D. (2004) · New England Journal of Medicine · doi:10.1056/nejmra030831 · Cited by 2,752 · see citing works
Goetz, M. P., Callstrom, M. R., Charboneau, J. W., Farrell, M. A., Maus, T. P., Welch, T. J., Wong, G. Y., Sloan, J. A., Novotny, P. J., Petersen, I. A., et al. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.03.097 · Cited by 607 · see citing works
Clinical outcomes of focused ultrasound surgery for the treatment of uterine fibroids
Stewart, E. A., Rabinovici, J., Tempany, C. M., Inbar, Y., Regan, L., Gastout, B., Hesley, G. K., Kim, H. S., Hengst, S., & Gedroye, W. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.04.072 · Cited by 480 · see citing works
Self-citationSze, W. M., Shelley, M. D., Held, I., Wilt, T. J., & Mason, M. D. (2003) · Clinical Oncology · doi:10.1016/s0936-6555(03)00113-4 · Cited by 432 · see citing works
Sustained Relief of Leiomyoma Symptoms by Using Focused Ultrasound Surgery
Stewart, E. A., Gostout, B. S., Rabinovici, J., et al. (2007) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000275283.39475.f6 · Cited by 332 · see citing works
MRI‐guided noninvasive ultrasound surgery
Hynynen, K., Darkazanli, A., Unger, E. C., & Schenck, J. F. (1993) · Medical Physics · doi:10.1118/1.597093 · Cited by 327 · see citing works
Chow, E., Wu, J. S.-Y., Hoskin, P., Coia, L. R., Bentzen, S. M., & Blitzer, P. H. (2002) · Radiotherapy and Oncology · doi:10.1016/s0167-8140(02)00170-6 · Cited by 315 · see citing works
MR-Guided Focused Ultrasound Surgery
Cline, H. E., Schenck, J. F., Hynynen, K., et al. (1992) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199211000-00024 · Cited by 315 · see citing works
Sustained Relief of Leiomyoma Symptoms by Using Focused Ultrasound Surgery
Stewart, E. A. (2008) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e318166e9da · Cited by 277 · see citing works
Management of bone metastases in cancer: A review
Selvaggi, G., & Scagliotti, G. V. (2005) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2005.03.011 · Cited by 268 · see citing works
Catane, R., Beck, A., Inbar, Y., Rabin, T., Shabshin, N., Hengst, S., Pfeffer, R. M., Hanannel, A., Dogadkin, O., Liberman, B., et al. (2006) · Annals of Oncology · doi:10.1093/annonc/mdl335 · Cited by 253 · see citing works
Self-citationFennessy, F. M., Tempany, C. M., McDannold, N. J., et al. (2007) · Radiology · doi:10.1148/radiol.2433060267 · Cited by 242 · see citing works
MAGNETIC RESONANCE IMAGING-GUIDED, HIGH-INTENSITY FOCUSED ULTRASOUND FOR BRAIN TUMOR THERAPY
Ram, Z., Cohen, Z. R., Harnof, S., Tal, S., Faibel, M., Nass, D., Maier, S. E., Hadani, M., & Mardor, Y. (2006) · Neurosurgery · doi:10.1227/01.neu.0000254439.02736.d8 · Cited by 213 · see citing works
Callstrom, M. R., Charboneau, J. W., Goetz, M. P., Rubin, J., Atwell, T. D., Farrell, M. A., Welch, T. J., & Maus, T. P. (2005) · Skeletal Radiology · doi:10.1007/s00256-005-0003-2 · Cited by 192 · see citing works
The evolving non-surgical ablation of breast cancer: Mr Guided focused ultrasound (MRgFUS)
Furusawa, H., Namba, K., Nakahara, H., Tanaka, C., Yasuda, Y., Hirabara, E., Imahariyama, M., & Komaki, K. (2007) · Breast Cancer · doi:10.2325/jbcs.14.55 · Cited by 181 · see citing works
MR imaging-controlled focused ultrasound ablation: a noninvasive image-guided surgery.
Jolesz, F., Hynynen, K., McDannold, N., & Tempany, C. (2005) · Magnetic Resonance Imaging Clinics of North America · doi:10.1016/j.mric.2005.04.008 · Cited by 174 · see citing works
A Systematic Overview of Radiation Therapy Effects in Skeletal Metastases
Falkmer, S., Järhult, J., Wersäll, P. J., & Cavallin-Ståhl, E. K. (2003) · Acta Oncologica · doi:10.1080/02841860310014895 · Cited by 167 · see citing works
Gianfelice, D., Khiat, A., Boulanger, Y., et al. (2003) · Journal of Vascular and Interventional Radiology · doi:10.1097/01.rvi.0000092900.73329.a2 · Cited by 162 · see citing works
Self-citationMagnetic resonance image-guided focused ultrasound surgery.
Jolesz, F. A., & Hynynen, K. (2003) · PubMed · Cited by 154 · see citing works
A simple method for production of trackless focal lesions with focused ultrasound: physical factors
Lele, P. P. (1962) · The Journal of Physiology · doi:10.1113/jphysiol.1962.sp006862 · Cited by 149 · see citing works
Gianfelice, D., Khiat, A., Amara, M., et al. (2003) · Breast Cancer Research and Treatment · doi:10.1023/b:brea.0000003956.11376.5b · Cited by 146 · see citing works
Self-citationPalliative radiotherapy in the treatment of skeletal metastases
Saarto, T., Janes, R., Tenhunen, M., & Kouri, M. (2002) · European Journal of Pain · doi:10.1016/s1090-3801(02)00028-9 · Cited by 136 · see citing works
Advances in FDG PET Probes in Surgical Oncology
Essner, R., Daghighian, F., & Giuliano, A. E. (2002) · The Cancer Journal · doi:10.1097/00130404-200203000-00004 · Cited by 124 · see citing works
Chapman, A., & ter Haar, G. (2007) · European Radiology · doi:10.1007/s00330-007-0644-8 · Cited by 106 · see citing works
General Principles of External Beam Radiation Therapy for Skeletal Metastases
Frassica, D. A. (2003) · Clinical Orthopaedics and Related Research · doi:10.1097/01.blo.0000093057.96273.fb · Cited by 102 · see citing works
Konski, A. A. (2004) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2004.05.053 · Cited by 88 · see citing works
Thermal effects of focused ultrasound energy on bone tissue
Smith, N. B., Temkin, J. M., Shapiro, F., et al. (2001) · Ultrasound in Medicine & Biology · doi:10.1016/s0301-5629(01)00454-9 · Cited by 79 · see citing works
Palliative irradiation of bone metastases
Poulsen, H. S., Nielsen, O. S., Klee, M., et al. (1989) · Cancer Treatment Reviews · doi:10.1016/0305-7372(89)90003-0 · Cited by 77 · see citing works
MAGNETIC RESONANCE IMAGING-GUIDED FOCUSED ULTRASOUND FOR THERMAL ABLATION IN THE BRAIN
Cohen, Z. R., Zaubermann, J., Harnof, S., et al. (2007) · Neurosurgery · doi:10.1227/01.neu.0000245606.99946.c6 · Cited by 64 · see citing works
Management of bone metastases in breast cancer
Lipton, A. (2005) · Current Treatment Options in Oncology · doi:10.1007/s11864-005-0023-0 · Cited by 59 · see citing works
Kopelman, D., Inbar, Y., Hanannel, A., et al. (2006) · HPB · doi:10.1080/13651820500465212 · Cited by 47 · see citing works
Self-citationKopelman, D., & Papa, M. Z. (2007) · Annals of Surgical Oncology · doi:10.1245/s10434-006-9326-z · Cited by 35 · see citing works
Prostate Cancer and Bone Metastases: Medical Treatment
Clark, P. E., & Torti, F. M. (2003) · Clinical Orthopaedics and Related Research · doi:10.1097/01.blo.0000093840.72468.e1 · Cited by 28 · see citing works
The role and limitations of radiofrequency ablation in treatment of bone and soft tissue tumors
Ahrar, K. (2004) · Current Oncology Reports · doi:10.1007/s11912-004-0042-1 · Cited by 27 · see citing works
Quality of Life and Symptom End Points in Palliative Bone Metastases Trials
Chow, E., Hoskin, P., van der Linden, Y. M., et al. (2005) · Clinical Oncology · doi:10.1016/j.clon.2005.06.016 · Cited by 27 · see citing works
Gedroyc, W. M. W., & Anstee, A. (2007) · Expert Review of Medical Devices · doi:10.1586/17434440.4.4.539 · Cited by 24 · see citing works
Pestalozzi, D. (2009) · Oncologia · doi:10.1159/000223672 · Cited by 5 · see citing works
Konski, A. A., Bruner, D. W., Feigenberg, S. J., et al. (2004) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2004.06.052 · Cited by 5 · see citing works
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Cited by
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MR-guided focused ultrasound thalamotomy for essential tremor: a proof-of-concept study
Lipsman, N., Schwartz, M. L., Huang, Y., Lee, L., Sankar, T., Chapman, M., Hynynen, K., & Lozano, A. M. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70048-6 · Cited by 604 · see citing works
Izadifar, Z., Izadifar, Z., Chapman, D., & Babyn, P. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020460 · Cited by 457 · see citing works
Mahoney, J. J., Hanlon, C. A., Marshalek, P. J., Rezai, A. R., & Krinke, L. (2020) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2020.117149 · Cited by 121 · see citing works
- Authors
- Liberman, B., Gianfelice, D., Inbar, Y., Beck, A., Rabin, T., Shabshin, N., Chander, G., Hengst, S., Pfeffer, R., Chechick, A., Hanannel, A., Dogadkin, O., & Catane, R.
- Affiliations
- Sheba Medical Center (IL)
- Toronto General Hospital (CA)
- Stiftung Charité (DE)
- InSightec (Israel) (IL)
- Corresponding author
- Liberman, Boaz
- Venue
- Annals of Surgical Oncology
- Published
- 2009-01
- Volume
- 16
- Issue
- 1
- Pages
- 140-146
- ISSN
- 1068-9265 (ISSN-L)
- 1534-4681
- OpenAlex
- W1974160564
- Cited by
- 296
- References
- 41
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 7 · 2023: 6 · 2022: 17 · 2021: 16 · 2020: 12 · 2019: 21 · 2018: 19 · 2017: 17 · 2016: 27 · 2015: 28 · 2014: 34 · 2013: 33 · 2012: 16
- FWCI
- 7.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Annals of Surgical Oncology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Health Sciences › Medicine › Surgery › Management of metastatic bone disease
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- MR-guided focused ultrasound, bone metastasis, pain palliation, thermal ablation, non-invasive treatment, visual analogue scale, treatment safety, device complications
- MeSH terms
- Adult, Aged, Aged, 80 and over, Bone Neoplasms, Female, Humans, Magnetic Resonance Imaging, Middle Aged, Palliative Care, Ultrasonic Therapy, Treatment Outcome, Pain Management
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