The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Recurrence of Adrenal Cortical Carcinoma Following Resection: Surgery Alone Can Achieve Results Equal to Surgery Plus Mitotane
Abstract
Background A recent nonrandomized interinstitutional study reported that adjuvant mitotane following surgery for adrenocortical carcinoma (ACC) was associated with decreased recurrence. Because of the limitations of this study, we investigated the influences of surgery and adjuvant mitotane in a large series of ACC patients evaluated and treated at a single referral center.Study design Retrospective evaluation of patients followed at a single institution after surgery for ACC.Results 218 patients with ACC underwent primary resection either at the index institution [surgery index (SI), n = 28] or an outside institution [surgery outside (SO), n = 190] and had a median follow-up of 88 months. SI patients had a superior disease-free survival compared with SO patients (median 25 versus 12 months, P = 0.003), and SI patients also had a superior overall survival compared with SO patients (median not reached versus 44 months, P = 0.02). Factors predicting increased risk of recurrence on multivariate analysis were surgery at an outside institution [hazard ratio (HR) 2.56, 95% confidence interval (CI) 1.44-4.53, P = 0.001] and no treatment with adjuvant mitotane (HR 1.95, 95% CI 1.06-3.59, P = 0.03), and those predicting a poorer survival were advanced stage at presentation (P = 0.01) and surgery at an outside institution (HR 2.62, 95% CI 1.31-5.25, P = 0.007).Conclusions The recurrence rate of the index group (50%) in the current series, the overwhelming majority of whom did not receive adjuvant mitotane, is indistinguishable from that reported for those who received adjuvant mitotane (49%) in the recent interinstitutional report, emphasizing the importance of completeness of initial surgery in the management of patients with ACC.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Two studies published by the M.D. Anderson Cancer Center reported a recurrence rate of 86% in the OA group (154 patients) and 100% in the LA group (6 patients) (251, 257).”
From Adrenocortical carcinoma (2014) · cites this paper as [257]
In the citing paper
“Local recurrence and peritoneal carcinomatosis was more common in the LA group.”
From Adrenocortical carcinoma (2014) · cites this paper as [257]
Citations
Cites
Adrenocortical Carcinoma: Clinical Update
Allolio, B., & Fassnacht, M. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2639 · Cited by 775
Adjuvant Mitotane Treatment for Adrenocortical Carcinoma
Terzolo, M., Angeli, A., Faßnacht, M., Daffara, F., Tauchmanovà, L., Conton, P. A., Rossetto, R., Buci, L., Sperone, P., Grossrubatscher, E. M., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa063360 · Cited by 759
Icard, P., Goudet, P., Charpenay, C., Andreassian, B., Carnaille, B., Chapuis, Y., Cougard, P., Henry, J., & Proye, C. (2001) · World Journal of Surgery · doi:10.1007/s00268-001-0047-y · Cited by 543
Management of patients with adrenal cancer: recommendations of an international consensus conference
Schteingart, D. E., Doherty, G. M., Gauger, P. G., Giordano, T. J., Hammer, G. D., Korobkin, M., & Worden, F. P. (2005) · Endocrine Related Cancer · doi:10.1677/erc.1.01029 · Cited by 421
Dackiw, A. P. B., Lee, J. E., Gagel, R. F., & Evans, D. B. (2001) · World Journal of Surgery · doi:10.1007/s00268-001-0030-7 · Cited by 390
Self-citationSchulick, R. D., & Brennan, M. F. (1999) · Annals of Surgical Oncology · doi:10.1007/s10434-999-0719-7 · Cited by 366
Haak, H. R., Hermans, J., van de Velde, C., Lentjes, E. G. W. M., Goslings, B. M., Fleuren, G. J., & Krans, H. (1994) · British Journal of Cancer · doi:10.1038/bjc.1994.183 · Cited by 329
Laparoscopic resection of adrenal cortical carcinoma: a cautionary note
Gonzalez, R. J., Shapiro, S., Sarlis, N., Vassilopoulou-Sellin, R., Perrier, N. D., Evans, D. B., & Lee, J. E. (2005) · Surgery · doi:10.1016/j.surg.2005.09.012 · Cited by 229
Self-citationIcard, P., Chapuis, Y., Andréassian, B., Bernard, A., & Proye, C. A. G. (1992) · PubMed · Cited by 179
The Cleveland Clinic experience with adrenal cortical carcinoma
Bodie, B., Novick, A. C., Pontes, J. E., Straffon, R. A., Montie, J. E., Babiak, T., Sheeler, L., & Schumacher, P. (1989) · Journal of Urology · doi:10.1016/s0022-5347(17)40734-8 · Cited by 145
Cited by
Sorted by citations
Items 101–158 of 158
Surgical approach to patients with hypercortisolism
Kiernan, C. M., & Solórzano, C. C. (2020) · Gland Surgery · doi:10.21037/gs.2019.12.13 · Cited by 11
Lui, M. S., Shirali, A. S., Huang, B. L., Fisher, S. B., & Perrier, N. D. (2022) · Surgical Oncology Clinics of North America · doi:10.1016/j.soc.2022.08.004 · Cited by 10
Self-citationSystemic therapy for adrenocortical carcinoma: a review
Johnson, J. E. H. (2020) · AME Medical Journal · doi:10.21037/amj.2020.01.07 · Cited by 11
Asadi, A. A., Hubbs, D., Sweigert, P. J., Baker, M. S., & Kabaker, A. S. (2020) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2020.10.038 · Cited by 10
Cancer of the Endocrine System
Asban, A. A., Patel, A. J., Reddy, S., Wang, T., Balentine, C. J., & Chen, H. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-47674-4.00068-2 · Cited by 10
Nastos, C., Papaconstantinou, D., Πασπάλα, Ά., Pararas, N. B., Vryonidou, A., Pikouli, A., Chronopoulou, E., Lechou, A., Peppa, Μ., & Pikoulis, E. A. (2024) · Langenbeck s Archives of Surgery · doi:10.1007/s00423-024-03507-5 · Cited by 7
Fahey, T. J. (2011) · Yearbook of Surgery · doi:10.1016/j.ysur.2011.04.005 · Cited by 7
Risk factors associated with positive resection margins in patients with adrenocortical carcinoma
Skertich, N. J., Tierney, J. F., Chivukula, S. V., Babazadeh, N. T., Hertl, M., Poirier, J., & Keutgen, X. M. (2020) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2020.02.043 · Cited by 7
Saito, T., Tojo, K., Furuta, N., Ono, K., Sasano, H., & Utsunomiya, K. (2011) · Internal Medicine · doi:10.2169/internalmedicine.50.4968 · Cited by 7
Bronswijk, M. J., Laenen, A., & Bechter, O. E. (2019) · Neoplasma · doi:10.4149/neo_2019_190105n17 · Cited by 7
Tsuboi, I., Parizi, M. K., Matsukawa, A., Mancon, S., Miszczyk, M., Schulz, R. J., Fazekas, T., Cadenar, A., Laukhtina, E., Kawada, T., et al. (2024) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2024.09.014 · Cited by 6
Atallah, S., Alassaf, H., Xu, Y., & El-Sayed, S. M. (2017) · Current Oncology · doi:10.3747/co.24.3533 · Cited by 6
Bellantone, R. D. A., & Crea, C. D. (2021) · Springer eBooks · doi:10.1007/978-3-030-84737-1_23 · Cited by 6
Factors Associated with Non–Operative Management of Resectable Adrenocortical Carcinoma
Tseng, J., DiPeri, T. P., Chen, Y., Ben-Shlomo, A., Shouhed, D., Phillips, E. H., Burch, M. A., & Jain, M. (2021) · Journal of Surgical Research · doi:10.1016/j.jss.2021.06.013 · Cited by 5
Zheng, G., Zhang, X., Li, H., Zhang, Y., Deng, J., & Wu, X. (2021) · Biochemical Genetics · doi:10.1007/s10528-021-10039-w · Cited by 6
Repeated resections for liver metastasis from primary adrenocortical carcinoma: A case report
Nakano, R., Satoh, D., Nakajima, H., 吉村, 友., Miyoshi, H., Yoshida, K., Matsukawa, H., Shiozaki, S., Ichimura, K., Okajima, M., et al. (2015) · International Journal of Surgery Case Reports · doi:10.1016/j.ijscr.2015.02.041 · Cited by 5
The Effect of Surgeon Expertise on the Outcome of Patients with Adrenocortical Carcinoma
Nekić, A. B., Knežević, N., Zibar, K., Kraljević, I., Balaško, A., Polovina, T. Š., Solak, M., Dušek, T., Kaštelan, D., & Croatian ACC Study Group (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12010100 · Cited by 4
Recurrent Amplification of the Osmotic Stress Transcription Factor NFAT5 in Adrenocortical Carcinoma
Brown, T. C., Nicolson, N. G., Man, J., Gibson, C. E., Stenman, A., Juhlin, C. C., Korah, R. M., & Carling, T. (2020) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaa060 · Cited by 3
Neurological adverse events of mitotane in adrenocortical carcinoma: results of a pilot study
Mormando, M., Galiè, E., Bianchini, M., Lauretta, R., Puliani, G., Tanzilli, A., Anceschi, U., Simone, G., Petreri, G., Graziano, G., et al. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1222002 · Cited by 5
Validated predictive model for treatment and prognosis of adrenocortical carcinoma
Zuber, S. M., Kuchta, K. M., Holoubek, S. A., Khokar, A. M., Moo‐Young, T. A., Prinz, R. A., & Winchester, D. J. (2023) · Surgery · doi:10.1016/j.surg.2023.08.047 · Cited by 3
Adrenal malignancy: still a contraindication for laparoscopy?
Schiavone, D., Torresan, F., Negro, S., Belluzzi, A., & Iacobone, M. (2019) · Laparoscopic Surgery · doi:10.21037/ls.2019.07.02 · Cited by 3
A current perspective on treatment of adrenocortical carcinoma
Terzolo, M., Francia, S. D., Ardito, A., Perotti, P., Ferrari, L., & Berruti, A. (2014) · Expert Opinion on Orphan Drugs · doi:10.1517/21678707.2014.931222 · Cited by 3
Ettaieb, M. H. T. (2020) · Research Publications (Maastricht University) · doi:10.26481/dis.20201218me · Cited by 4
Pulmonary Metastasectomy for Adrenocortical Carcinoma—Not If, but When
Carr, S. R., Hernandez, F., Varghese, D. G., Choo‐Wosoba, H., Steinberg, S. M., Teke, M. E., Rivero, J. D., Schrump, D. S., & Hoang, C. D. (2024) · Cancers · doi:10.3390/cancers16040702 · Cited by 2
Shariq, O. A., Kensing, B. C., Landry, J. P., Tzeng, C.-W. D., Habra, M. A., Campbell, M. T., Fisher, S. B., Perrier, N. D., Lee, J. E., & Graham, P. H. (2025) · Surgery · doi:10.1016/j.surg.2025.109696 · Cited by 2
Self-citationTokura, Y., Kobayashi, M., & Kamai, T. (2020) · IJU Case Reports · doi:10.1002/iju5.12196 · Cited by 1
Rah, C.-S., Cho, J. W., Kim, W. W., Lee, Y., Chung, K., Koh, J., Lee, S. H., Lee, J., Song, D. E., Hong, S. J., et al. (2022) · Gland Surgery · doi:10.21037/gs-22-274 · Cited by 2
Self-citationYaşar, A., Aktaş, B. Y., Uçar, G., Goksu, S. S., Bilgetekin, İ., Çakar, B., Sakin, A., Ateş, Ö., Başoğlu, T., Arslan, Ç., et al. (2024) · Clinical Genitourinary Cancer · doi:10.1016/j.clgc.2024.102077 · Cited by 3
Creemers, S. G., Hofland, L. J., & Feelders, R. A. (2016) · Springer eBooks · doi:10.1007/978-3-319-44136-8_12 · Cited by 2
Perspectives on Adrenal Tumor Surgery
Baston, C., Parosanu, A., Moldoveanu, O., Discalicău, L., Visinescu, P., Precup, A., & Sinescu, I. (2025) · Medicina · doi:10.3390/medicina62010003 · Cited by 1
Flauto, F., Neola, G., Vitale, F., & Damiano, V. (2026) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2026.105346 · Cited by 1
A case of metastatic liver cancer with hormone secretion: a case report
Quan, C., Zhang, Y., & Wang, Y. (2021) · Gland Surgery · doi:10.21037/gs-21-296 · Cited by 1
Present and Future of Personalised Medicine for Endocrine Cancers
Ronchi, C. L., & Altieri, B. (2022) · MDPI eBooks · doi:10.3390/books978-3-0365-4329-1 · Cited by 1
Kwon, D., Rah, C.-S., Kim, B.-C., Pak, S. J., Cho, J. W., Kim, W. W., Lee, Y., Lee, J., Song, D. E., Chung, K., et al. (2024) · Annals of Surgical Treatment and Research · doi:10.4174/astr.2024.107.4.187 · Cited by 1
Self-citationSurgery for Adrenocortical Cancer: Evidence-Based Recommendations
Mihai, R. (2018) · Springer eBooks · doi:10.1007/978-981-10-1124-5_29 · Cited by 1
Kerkhofs, T. M. A. (2015) · doi:10.26481/dis.20151112tk · Cited by 1
Phan, A. T., & Jiménez, C. (2011) · Humana Press eBooks · doi:10.1007/978-1-60327-997-0_12 · Cited by 1
Self-citationLiver Metastases from Adrenocortical Carcinomas
Toro, A., & Carlo, I. D. (2014) · Springer eBooks · doi:10.1007/978-3-319-09293-5_1 · Cited by 1
Allolio, B., Brix, D., & Faßnacht, M. (2010) · European Urology · doi:10.1016/j.eururo.2010.09.002
Carcinoma adrenal de rápida evolución
Calero, T. M. G., González, A. I. C., Martínez, J. C., & Curi, L. (2013) · DOAJ (DOAJ: Directory of Open Access Journals)
Therapies for Locally Advanced and Metastatic Adrenocortical Carcinoma
Rao, S. N., & Habra, M. A. (2016) · Springer eBooks · doi:10.1007/978-3-319-44136-8_14
Adrenal Cortical Carcinoma: Mitotane and Beyond
Francia, S. D., Perotti, P., Basile, V., Germano, A., & Terzolo, M. (2017) · Contemporary Endocrinology · doi:10.1007/978-3-319-62470-9_13
Phan, A. T., Habra, M. A., Grubbs, E. G., & Moran, C. A. (2012) · Wiley eBooks · doi:10.1002/9781118464557.ch10
Self-citationAdvances in the Diagnosis and Management of Adrenocortical Carcinoma
Fisher, S. B., Asare, E. A., Habra, M. A., & Perrier, N. D. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-66195-9.00016-9
Self-citationAllolio, B., & Faßnacht, M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00107-4
Hamidi, M., Mavros, M. N., Devon, K. M., Kulkarni, G. S., Law, C., Urbach, D. R., Hallet, J. I., & Pasternak, J. D. (2020) · Springer eBooks · doi:10.1007/978-3-030-48363-0_1 · Cited by 1
Results of surgical treatment of localized and locally advanced adrenocortical cancer in children
Temnyy, А. S., Казанцев, А. П., Акшенович, К. П., Kalinchenko, N. Y., Rubanskaya, M. V., Sardalova, S. A., & Варфоломеева, С. Р. (2021) · Russian Journal of Pediatric Hematology and Oncology · doi:10.21682/2311-1267-2021-8-2-42-49
Waldmann, J. (2021) · Springer Reference Medizin · doi:10.1007/978-3-662-61724-3_36-1
Stewart, A. A., & Story, E. S. (2017) · Wiley eBooks · doi:10.1002/9781119196235.ch47
Landwehr, L., Schreiner, J., Appenzeller, S., Kircher, S., Herterich, S., Faßnacht, M., Kroiß, M., & Weigand, I. (2020) · Research Square · doi:10.21203/rs.3.rs-125950/v1
Malignant Tumors of the Adrenal Gland
Lee, J. E., Habra, M. A., & Campbell, M. T. (2022) · Holland‐Frei Cancer Medicine · doi:10.1002/9781119000822.hfcm082.pub2
Self-citationWaldmann, J. (2022) · Springer Reference Medizin · doi:10.1007/978-3-662-63317-5_36
Adrenocortical cancer: late diagnosis of the disease on the example of a clinical case. Case report
Starostina, E. A. (2023) · Terapevticheskii arkhiv · doi:10.26442/00403660.2023.12.202430
Prognostic Factors Among Patients with Non-metastatic Adrenocortical Carcinoma
Ohsugi, H., Takizawa, N., Nakamoto, T., Mishima, T., Uchida, K., & Kinoshita, H. (2025) · Intern J Endocrinol Metab · doi:10.5812/ijem-159772
Endocrine Disorders and Tumors
Santore, M. T., Clifton, M. S., & Alemayehu, H. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-12431-0.00072-3
Gonzalez-Clavijo, A. M., Maya, L. F. F., Ballén, D. F., Devia, D. G., Cuellar, A. A. C., García, M., González-Ramírez, D. M., Tapiero-García, M., Román-Gonzaléz, A., Cabrera, M., et al. (2026) · Endocrine Oncology · doi:10.1530/eo-26-0079
Metadata
- Authors
- Grubbs, E. G., Callender, G. G., Xing, Y., Perrier, N. D., Evans, D. B., Phan, A. T., & Lee, J. E.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Medical College of Wisconsin (US)
- Corresponding author
- Lee, Jeffrey E.
- ORCID
- Venue
- Annals of Surgical Oncology
- Published
- 2009-10-23
- Volume
- 17
- Issue
- 1
- Pages
- 263-270
- ISSN
- 1068-9265 (ISSN-L)
- 1534-4681
- OpenAlex
- W2046048324
- Cited by
- 158
- References
- 20
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 5 · 2023: 6 · 2022: 10 · 2021: 13 · 2020: 18 · 2019: 10 · 2018: 12 · 2017: 10 · 2016: 5 · 2015: 16 · 2014: 11 · 2013: 11 · 2012: 8
- FWCI
- 8.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Annals of Surgical Oncology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Oncology › Renal cell carcinoma treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- adrenocortical carcinoma, recurrence, adrenalectomy, disease-free survival, overall survival, stage at diagnosis, surgical resection
- MeSH terms
- Adolescent, Adrenal Cortex Neoplasms, Adult, Aged, Child, Child, Preschool, Combined Modality Therapy, Female, Follow-Up Studies, Humans, Male, Middle Aged, Mitotane, Neoplasm Recurrence, Local, Neoplasm Staging, Retrospective Studies, Survival Rate, Treatment Outcome, Chemotherapy, Adjuvant, Adrenocortical Carcinoma, Antineoplastic Agents, Hormonal, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
