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Cited by 366Adrenal and Paraganglionic TumorsRenal cell carcinoma treatmentAdrenal Hormones and Disorders

Long-term survival after complete resection and repeat resection in patients with adrenocortical carcinoma

Schulick, Richard D., Brennan, Murray F.·1999·Annals of Surgical Oncology
DOI 10.1007/s10434-999-0719-7
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Abstract

Background One of the key issues in the treatment of adrenocortical carcinoma is the efficacy of repeat resection of local recurrence and metastatic disease in affected patients. Options in the treatment of locally recurrent or metastatic disease are limited because chemotherapy and radiotherapy generally do not provide any significant prolongation in survival in treated patients.Methods A series of 113 patients who presented to Memorial Sloan-Kettering Cancer Center for treatment of adrenocortical carcinoma are presented.Results The median overall survival for all 113 patients was 38 months (5-year survival, 37%). Patients presenting with early stage I or II disease (n = 57) had a median survival of 101 months (5-year survival, 60%), whereas those with late stage III or IV disease (n = 56) had a median survival of 15 months (5-year survival, 10%). Patients who had complete primary resection (n = 68) had a median survival of 74 months (5-year survival, 55%), whereas those with incomplete primary resection (n = 45) had a median survival of 12 months (5-year survival, 5%). Resection of locally recurrent or distant metastatic disease was performed in 47 of these patients. Patients who had a complete second resection had a median survival of 74 months (5-year survival, 57%), whereas those with incomplete second resection had a median survival of 16 months (5-year survival, 0%).Conclusions Improved survival is seen in patients who present with early stage and have complete primary resection. Patients who undergo complete repeat resection of local recurrence or distant metastasis also have improved survival. Complete repeat resection was more readily accomplished in discrete distant metastatic lesions compared with bulky local recurrences.

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Crossref · 10.1007/s10434-999-0719-7

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24 of 24 references verified0 citation errors · 0 not checkable

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  • A 1999 study reported median survival of 74 months (5-year survival, 57%) in those undergoing complete second resections versus median survival of 16 months (5-year survival, 0%) in those undergoing incomplete second resection.

    “A 1999 study reported median survival of 74 months (5-year survival, 57%) in those undergoing complete second resections vs a median survival of 16 months (5-year survival, 0%) in those undergoing incomplete second resection.”

    From Adrenocortical carcinoma (2014) · cites this paper as [266]

  • Two early reports state radiotherapy is ineffective but offer no details regarding patient or treatment characteristics.

    “For example, 2 early reports state that radiotherapy is ineffective, but they offer no details regarding patient or treatment characteristics (266, 339).”

    From Adrenocortical carcinoma (2014) · cites this paper as [266]

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Authors
Schulick, R. D., & Brennan, M. F.
Affiliations
Memorial Sloan Kettering Cancer Center (US)
Corresponding author
Brennan, Murray F.
ORCID
Venue
Annals of Surgical Oncology
Publisher
Springer Science and Business Media LLC
Published
1999-12
Volume
6
Issue
8
Pages
719-726
ISSN
  • 1068-9265 (ISSN-L)
  • 1534-4681
DOI
10.1007/s10434-999-0719-7
OpenAlex
W1965293262
Cited by
366
References
24
Citations by year
2026: 5 · 2025: 9 · 2024: 12 · 2023: 8 · 2022: 21 · 2021: 18 · 2020: 17 · 2019: 14 · 2018: 25 · 2017: 12 · 2016: 11 · 2015: 28 · 2014: 21 · 2013: 10 · 2012: 18
FWCI
4.83
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Annals of Surgical Oncology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Renal cell carcinoma treatment
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
adrenocortical carcinoma, adrenalectomy, R0 resection, repeat resection, local recurrence, distant metastasis, overall survival, tumor stage, incomplete resection
MeSH terms
Adolescent, Adrenal Cortex Neoplasms, Adult, Aged, Aged, 80 and over, Child, Female, Humans, Middle Aged, Neoplasm Recurrence, Local, Neoplasm Staging, Reoperation, Time Factors, Survival Rate, Adrenocortical Carcinoma

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