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Cited by 145Adrenal and Paraganglionic TumorsRenal cell carcinoma treatmentAdrenal Hormones and Disorders

The Cleveland Clinic experience with adrenal cortical carcinoma

Bodie, Barry, Novick, Andrew C., Pontes, J. Edson, Straffon, Ralph A., Montie, James E., Babiak, Theresa, Sheeler, Leslie, Schumacher, Peter·1989·Journal of Urology
DOI 10.1016/s0022-5347(17)40734-8
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Abstract

Between 1936 and 1987, 82 patients with adrenal cortical carcinoma were seen at our clinic. Of these patients 49 (72 per cent) have been seen during the last 25 years. A total of 40 patients (48.8 per cent) presented with a hormonally functional tumor and 42 (51.2 per cent) had a nonfunctional tumor. Forty patients (48.8 per cent) presented with localized disease, 12 (14.6 per cent) with regional disease and 30 (36.6 per cent) with distant metastases. Complete surgical removal of all gross tumor was achieved in 49 patients. Over-all 3 and 5-year patient survival rates in this series were 37.5 and 25.1 per cent, respectively. Survival was significantly improved (43.9 per cent at 5 years, p equals 0.0001) in patients with localized disease that was completely removed surgically; postoperative adjuvant therapy with op'-DDD was of no benefit in these patients. Survival in patients with metastatic disease was poor and was not improved by treatment with op'-DDD, cytotoxic chemotherapy or radiation therapy.

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Crossref · 10.1016/s0022-5347(17)40734-8

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  • Three other studies found radiotherapy ineffective based on experiences in 2, 3, and 5 patients, respectively.

    “Three other studies found radiotherapy to be ineffective on the basis of experiences in 2, 3, and 5 patients, respectively (275, 340, 341).”

    From Adrenocortical carcinoma (2014) · cites this paper as [340]

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Authors
Bodie, B., Novick, A. C., Pontes, J. E., Straffon, R. A., Montie, J. E., Babiak, T., Sheeler, L., & Schumacher, P.
Affiliations
Cleveland Clinic (US)
ORCID
Venue
Journal of Urology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1989-02
Volume
141
Issue
2
Pages
257-260
ISSN
  • 0022-5347 (ISSN-L)
  • 1527-3792
DOI
10.1016/s0022-5347(17)40734-8
OpenAlex
W2415859171
Cited by
145
References
20
Citations by year
2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 5 · 2013: 1 · 2012: 6
FWCI
3.25
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Journal of Urology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Renal cell carcinoma treatment
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
adrenocortical carcinoma, functional adrenal tumors, metastatic disease, surgical resection, adjuvant therapy, cytotoxic chemotherapy, radiotherapy, survival rate
MeSH terms
Actuarial Analysis, Adrenal Cortex Neoplasms, Adrenalectomy, Adult, Carcinoma, Child, Combined Modality Therapy, Female, Follow-Up Studies, Humans, Male, Mitotane, Ohio, Prognosis, Time Factors

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