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Cited by 464

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Interaction of Phytoestrogens with Estrogen Receptors .ALPHA. and .BETA.(II).

Open access
Morito, Keiko, Aomori, Tohru, Hirose, Toshiharu, Kinjo, Junei, Hasegawa, Junichi, Ogawa, Sumito, Inoue, Satoshi, Muramatsu, Masami, Masamune, Yukito·2002·Biological and Pharmaceutical Bulletin

Abstract

We investigated the estrogenic activities of isoflavone derivatives in competition binding assays with human estrogen receptor (hER) alpha or hER beta protein, and in a gene expression assay using a yeast system. Coumestrol binds as strongly as 17beta-estradiol to both hERs. Biochanin A, 5-OMe-genistein, formononetin, and tectorigenin bind well to hER beta, but significant binding to hER alpha is only observed with 5-OMe-genistein, formononetin and tectorigenin. The binding of 7-OMe-genistein and irisolidone is poor to both receptors. Among the glucosides, sissotorin binds both receptors and the binding is stronger than genistin. Coumestrol induces transcription as strongly as genistein. Tectorigenin also induces transcription with both hERs. Though biochanin A, 5-OMe-genistein, 7-OMe-genistein, irisolidone and formononetin slightly induce transcription with hER beta, they act as antagonists in the induction of transcription by 17beta-estradiol. The results show that methylation or glucosidation of isoflavones generally inhibits their phytoestrogenic activities.

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Metadata

Authors
Morito, K., Aomori, T., Hirose, T., Kinjo, J., Hasegawa, J., Ogawa, S., Inoue, S., Muramatsu, M., & Masamune, Y.
Venue
Biological and Pharmaceutical Bulletin
Published
2002
Volume
25
Issue
1
Pages
48-52
ISSN
  • 0918-6158 (ISSN-L)
  • 1347-5215
OpenAlex
W3169342595
Cited by
464
References
3
FWCI
15.29
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Interaction of Phytoestrogens with Estrogen Receptors .ALPHA. and .BETA.(II). https://app.cochat.ai/papers/10.1248/bpb.25.48
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Morito, K., Aomori, T., Hirose, T., Kinjo, J., Hasegawa, J., Ogawa, S., Inoue, S., Muramatsu, M., & Masamune, Y. (2002). Interaction of Phytoestrogens with Estrogen Receptors .ALPHA. and .BETA.(II). Biological and Pharmaceutical Bulletin. https://doi.org/10.1248/bpb.25.48

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