Protective Effects of the Fermented Milk Kefir on X-Ray Irradiation-Induced Intestinal Damage in B6C3F1 Mice
Open accessAbstract
Gastrointestinal damage associated with radiation therapy is currently an inevitable outcome. The protective effect of Kefir was assessed for its usefulness against radiation-induced gastrointestinal damage. A Kefir supernatant was diluted by 2- or 10-fold and administered for 1 week prior to 8 Gray (Gy) X-ray irradiation at a dose rate of 2 Gy/min, with an additional 15 d of administration post-irradiation. The survival rate of control mice with normal drinking water dropped to 70% on days 4 through 9 post-irradiation. On the other hand, 100% of mice in the 10- and 2-fold-diluted Kefir groups survived up to day 9 post-irradiation (p<0.05 and p<0.01, respectively). Examinations for crypt regeneration against 8, 10 and 12 Gy irradiation at a dose rate of 4 Gy/min revealed that the crypt number was significantly increased in the mice administered both diluted Kefir solutions (p<0.01 for each). Histological and immunohistochemical examinations revealed that the diluted Kefir solutions protected the crypts from radiation, and promoted crypt regeneration. In addition, lyophilized Kefir powder was found to significantly recover the testis weights (p<0.05), but had no effects on the body and spleen weights, after 8 Gy irradiation. These findings suggest that Kefir could be a promising candidate as a radiation-protective agent.
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Recent studies have explored beneficial effects of probiotics far beyond the intestine, including healthier skin, improvement of eczema, atopic dermatitis and burns, healing of scars, and rejuvenation.
“Recent studies have explored the beneficial effects of probiotics far beyond the intestine.Some of these novel benefits include healthier skin, improvement of eczema, atopic dermatitis and burns, healing of scars, and rejuvenation (91) .”
From Milk <i>kefir</i> : nutritional, microbiological and health benefits (2017) · cites this paper as [91]
The introduction (p. 1) describes research on Kefir’s effects beyond the intestine, including breast cancer, and the Discussion (p. 6) reports antioxidant effects in the liver and kidney. Neither passage supports the attributed benefits for skin, eczema, atopic dermatitis, burns, scars, or rejuvenation; a search for those terms found no relevant passage. (LLM, conf=0.82)
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- Authors
- Teruya, K., Myojin-Maekawa, Y., Shimamoto, F., Watanabe, H., Nakamichi, N., Tokumaru, K., Tokumaru, S., & Shirahata, S.
- Affiliations
- Kyushu University (JP)
- Prefectural University of Hiroshima (JP)
- Hiroshima University (JP)
- Nihon Kefir Co., Ltd.
- Venue
- Biological and Pharmaceutical Bulletin
- Publisher
- Pharmaceutical Society of Japan
- Published
- 2013
- Volume
- 36
- Issue
- 3
- Pages
- 352-359
- ISSN
- 0918-6158 (ISSN-L)
- 1347-5215
- OpenAlex
- W2014292869
- Cited by
- 15
- References
- 48
- Citations by year
- 2024: 2 · 2022: 2 · 2021: 1 · 2020: 2 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 1
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biological and Pharmaceutical Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (publishedVersion)
- Hiroshima University Institutional Repository (submittedVersion, other-oa)
- Hiroshima University Acedemic Information Repository (Hiroshima University) (submittedVersion)
- Funders
- Japan Society for the Promotion of Science (23580172)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Agricultural and Biological Sciences › Food Science › Radiation Effects and Dosimetry
- Keywords
- kefir, fermented milk, radiation protection, X-ray irradiation, intestinal injury, crypt regeneration, gastrointestinal toxicity, radiation-induced mortality, testicular weight, B6C3F1 mice
- MeSH terms
- Animals, Drinking, Immunohistochemistry, Intestines, Male, Organ Size, Radiation-Protective Agents, Spleen, Testis, X-Rays, Cultured Milk Products, Mice
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