Studies on the drugs for peptic ulcer. A reliable method for producing stress ulcer in rats
Open accessAbstract
A simple and reliable method for production of gastric ulcer on rats by stress was described. Rats fixed on boards were immersed in water of 25°to the depth of xiphoide. After 20 hours, marked gastric erosions were found in the glandular portion of the stomach. This stress is more favourable than other stresses as cold, restraint, or emotional stress by stress box in view of incidence and mortality. Anticholinergics or central depressants effectively inhibited the ulceration and combination of both drugs suppressed it more effectively than single administration of each drug.
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The models of esophagitis used combined two elements known to contribute to esophageal injury: hyperglycemia and exposure to restraint-stress.
“The models of esophagitis used combined two elements known to contribute to esophageal injury: hyperglycemia [36] and exposure to restraint-stress [13], [37].”
From Cytoprotective Effects of Hydrogen Sulfide in Novel Rat Models of Non-Erosive Esophagitis (2014) · cites this paper as [37]
The Comparison of Various Stressors (pp. 4–5) describes restraint stress in rats and reports gastric ulcers in the restraint group. The paper does not establish that restraint stress contributes to esophageal injury; its observed lesions were in the stomach (The Incidence of Stress Ulcer, p. 2). The hyperglycemia clause is attached to a different citation and is not assessed here. (LLM, conf=0.87)
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Cited by
Sorted by citations
Restraint stress in biomedical research: A review
Paré, W. P., & Glavin, G. B. (1986) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(86)90017-5 · Cited by 376 · see citing works
Cytoprotective Effects of Hydrogen Sulfide in Novel Rat Models of Non-Erosive Esophagitis
Zayachkivska, O., Havryluk, O., Hrycevych, N., Bula, N., Grushka, O., & Wallace, J. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110688 · Cited by 34 · see citing works
“[37] that involves short-term exposure to water-immersion stress.”
Background
- Authors
- Takagi, K., Kasuya, Y., & Watanabe, K.
- Affiliations
- The University of Tokyo (JP)
- Venue
- Chemical and Pharmaceutical Bulletin
- Publisher
- Pharmaceutical Society of Japan
- Published
- 1964
- Volume
- 12
- Issue
- 4
- Pages
- 465-472
- ISSN
- 0009-2363 (ISSN-L)
- 1347-5223
- OpenAlex
- W1573533055
- Cited by
- 208
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 2 · 2018: 5 · 2017: 4 · 2016: 3 · 2015: 5 · 2014: 5 · 2013: 4 · 2012: 2
- FWCI
- 2.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Chemical and Pharmaceutical Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal Bleeding Diagnosis and Treatment
- Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Keywords
- peptic ulcer, stress-induced gastric ulcer, gastric erosions, rat model, anticholinergic agents, central nervous system depressants, combination therapy, ulcer prevention
- MeSH terms
- Atropine, Hypnotics and Sedatives, Parasympatholytics, Peptic Ulcer, Pharmacology, Research, Stomach Ulcer, Stress, Physiological, Tranquilizing Agents, Ulcer, Rats
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