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Inhibition of Prostaglandin and Leukotriene Biosynthesis by Gingerols and Diarylheptanoids.
Open accessAbstract
The rhizomes of Zingiber officinale (ginger) and Alpinia officinarum contain potent inhibitors against prostaglandin biosynthesizing enzyme (PG synthetase). Gingerols and diarylhepatanoids were identified as active compounds. Their possible mechanism of action which was deduced from the structures of active compounds indicated that the inhibitors would also be active against arachidonate 5-lipoxygenase, an enzyme of leukotriene (LT) biosynthesis. This was verified by testing their inhibitory effects on 5-lipoxygenase prepared from RBL-1 cells. A diarylheptanoid with catechol group was the most active compound against 5-lipoxygenase, while yakuchinone A was the most active against PG synthetase.
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Metadata
- Authors
- KIUCHI, F., IWAKAMI, S., SHIBUYA, M., HANAOKA, F., & SANKAWA, U.
- Venue
- Chemical and Pharmaceutical Bulletin
- Publisher
- Pharmaceutical Society of Japan
- Published
- 1992
- Volume
- 40
- Issue
- 2
- Pages
- 387-391
- ISSN
- 0009-2363 (ISSN-L)
- 1347-5223
- OpenAlex
- W1981021151
- Cited by
- 345
- References
- 0
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- bronze
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- KIUCHI, F., IWAKAMI, S., SHIBUYA, M., HANAOKA, F., & SANKAWA, U. (1992). Inhibition of Prostaglandin and Leukotriene Biosynthesis by Gingerols and Diarylheptanoids. Chemical and Pharmaceutical Bulletin. https://doi.org/10.1248/cpb.40.387
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
