The DOI matches its Crossref record.
Antimycobacterial Activity of Prenylated Xanthones from the Fruits of Garcinia mangostana
Open accessAbstract
Prenylated xanthones, isolated from the fruit hulls and the edible arils and seeds of Garcinia mangostana, were tested for their antituberculosis potential. Alpha- and beta-mangostins and garcinone B exhibited strong inhibitory effect against Mycobacterium tuberculosis with the minimum inhibitory concentration (MIC) value of 6.25 microg/ml. Tri- and tetra-oxygenated xanthones with di-C5 units or with a C5 and a modified C5 groups are essential for high activities. Substitution in the A and C rings has been shown to modify the bioactivity of the compounds.
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Citations
Cited by
Antioxidant Xanthones from the Pericarp of Garcinia mangostana (Mangosteen)
Jung, H.-A., Su, B.-N., Keller, W. J., Mehta, R. G., & Kinghorn, A. D. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf052649z · Cited by 512
Garcinia mangostana L.: a phytochemical and pharmacological review
Obolskiy, D., Pischel, I., Siriwatanametanon, N., & Heinrich, M. (2009) · Phytotherapy Research · doi:10.1002/ptr.2730 · Cited by 366
Wittenauer, J., Falk, S., Schweiggert-Weisz, U., & Carle, R. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.02.094 · Cited by 90
Metadata
- Authors
- Suksamrarn, S., Suwannapoch, N., Phakhodee, W., Thanuhiranlert, J., Ratananukul, P., Chimnoi, N., & Suksamrarn, A.
- Venue
- Chemical and Pharmaceutical Bulletin
- Publisher
- Pharmaceutical Society of Japan
- Published
- 2003
- Volume
- 51
- Issue
- 7
- Pages
- 857-859
- ISSN
- 0009-2363 (ISSN-L)
- 1347-5223
- OpenAlex
- W1965051826
- Cited by
- 261
- References
- 0
- FWCI
- 3.82
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Suksamrarn, S., Suwannapoch, N., Phakhodee, W., Thanuhiranlert, J., Ratananukul, P., Chimnoi, N., & Suksamrarn, A. (2003). Antimycobacterial Activity of Prenylated Xanthones from the Fruits of Garcinia mangostana. Chemical and Pharmaceutical Bulletin. https://doi.org/10.1248/cpb.51.857
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