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Cytotoxic Prenylated Xanthones from the Young Fruit of Garcinia mangostana
Open accessAbstract
Three new prenylated xanthones, mangostenones C (1), D (2), and E (3), together with 16 known xanthones 4-19, were isolated from the young fruit (7-week maturity stage) of Garcinia mangostana. The structural elucidation of the new compounds was mainly established on the basis of 1D and 2D NMR and HR-MS spectroscopic analysis. Compound 1 showed cytotoxic properties against three human cancer cell lines, epidermoid carcinoma of the mouth (KB), breast cancer (BC-1), and small cell lung cancer (NCI-H187), with IC50 values of 2.8, 3.53, and 3.72 microg/ml, respectively. Among the isolates, alpha-mangostin (12), the major metabolite, exhibited the most potent effects against the BC-1 cells with an IC50 value of 0.92 microg/ml, an activity greater than that of the standard drug ellipticine (IC50 = 1.46 microg/ml). Compound 12 also showed the highest activity against KB cells, while gartanin (10) displayed the strongest activity against the NCI-H187 cells at the respective IC50 values of 2.08 microg/ml and 1.08 microg/ml.
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Citations
Cited by
Garcinia mangostana L.: a phytochemical and pharmacological review
Obolskiy, D., Pischel, I., Siriwatanametanon, N., & Heinrich, M. (2009) · Phytotherapy Research · doi:10.1002/ptr.2730 · Cited by 366
Anti-Cancer Effects of Xanthones from Pericarps of Mangosteen
Akao, Y., Nakagawa, Y., & Nozawa, Y. (2008) · International Journal of Molecular Sciences · doi:10.3390/ijms9030355 · Cited by 275
Ryu, H. W., Cho, J. K., Curtis-Long, M. J., Yuk, H. J., Kim, Y. S., Jung, S., Kim, Y. S., Lee, B. W., & Park, K. H. (2011) · Phytochemistry · doi:10.1016/j.phytochem.2011.08.007 · Cited by 161
Metadata
- Authors
- Suksamrarn, S., Komutiban, O., Ratananukul, P., Chimnoi, N., Lartpornmatulee, N., & Suksamrarn, A.
- Venue
- Chemical and Pharmaceutical Bulletin
- Publisher
- Pharmaceutical Society of Japan
- Published
- 2006
- Volume
- 54
- Issue
- 3
- Pages
- 301-305
- ISSN
- 0009-2363 (ISSN-L)
- 1347-5223
- OpenAlex
- W2160884845
- Cited by
- 240
- References
- 0
- FWCI
- 10.07
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Suksamrarn, S., Komutiban, O., Ratananukul, P., Chimnoi, N., Lartpornmatulee, N., & Suksamrarn, A. (2006). Cytotoxic Prenylated Xanthones from the Young Fruit of Garcinia mangostana. Chemical and Pharmaceutical Bulletin. https://doi.org/10.1248/cpb.54.301
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