Cited by 347Cardiovascular Effects of ExerciseCardiovascular and exercise physiologyCardiomyopathy and Myosin Studies

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Disproportionate Exercise Load and Remodeling of the Athlete's Right Ventricle

LA GERCHE, ANDRÉ, HEIDBÜCHEL, HEIN, BURNS, ANDREW T., MOONEY, DON J., TAYLOR, ANDREW J., PFLUGER, HEINZ B., INDER, WARRICK J., MACISAAC, ANDREW I., PRIOR, DAVID L.·2011·Medicine & Science in Sports & Exercise

DOI 10.1249/mss.0b013e31820607a3

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Abstract

Purpose There is evolving evidence that intense exercise may place a disproportionate load on the right ventricle (RV) when compared with the left ventricle (LV) of the heart. Using a novel method of estimating end-systolic wall stress (ES-σ), we compared the RV and LV during exercise and assessed whether this influenced chronic ventricular remodeling in athletes. Methods For this study, 39 endurance athletes (EA) and 14 nonathletes (NA) underwent resting cardiac magnetic resonance (CMR), maximal oxygen uptake (VO2), and exercise echocardiography studies. LV and RV end-systolic wall stress (ES-σ) were calculated using the Laplace relation (ES-σ = Pr/(2h)). Ventricular size and wall thickness were determined by CMR; invasive and Doppler echo estimates were used to measure systemic and pulmonary ventricular pressures, respectively; and stroke volume was quantified by Doppler echocardiography and used to calculate changes in ventricular geometry during exercise. Results In EA, compared with NA, resting CMR measures showed greater RV than LV remodeling. The ratios RV ESV/LV ESV (1.40 ± 0.23 vs 1.26 ± 0.12, P = 0.007) and RV mass/LV mass (0.29 ± 0.04 vs 0.25 ± 0.03, P = 0.012) were greater in EA than in NA. RVES-σ was lower at rest than LVES-σ (143 ± 44 vs 252 ± 49 kdyn · cm, P Conclusions Exercise induces a relative increase in RVES-σ which exceeds LVES-σ. In athletes, greater RV enlargement and greater wall thickening may be a product of this disproportionate load excess.

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Authors: LA GERCHE, A., HEIDBÜCHEL, H., BURNS, A. T., MOONEY, D. J., TAYLOR, A. J., PFLUGER, H. B., INDER, W. J., MACISAAC, A. I., & PRIOR, D. L.
Affiliations: Universitair Ziekenhuis Leuven (BE)
St Vincent's Hospital Melbourne (AU)
Baker Heart and Diabetes Institute (AU)
The University of Melbourne (AU)
ORCID: HEIDBÜCHEL, HEIN
BURNS, ANDREW T.
TAYLOR, ANDREW J.
INDER, WARRICK J.
MACISAAC, ANDREW I.
PRIOR, DAVID L.
Venue: Medicine & Science in Sports & Exercise
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2011-06
Volume: 43
Issue: 6
Pages: 974-981
ISSN: 0195-9131 (ISSN-L)
DOI: 10.1249/mss.0b013e31820607a3
OpenAlex: W1976805840
Cited by: 347
References: 42
Citations by year: 2026: 8 · 2025: 17 · 2024: 14 · 2023: 11 · 2022: 28 · 2021: 25 · 2020: 36 · 2019: 22 · 2018: 36 · 2017: 27 · 2016: 23 · 2015: 33 · 2014: 24 · 2013: 16 · 2012: 19
FWCI: 9.22
Type: journal article
Language: en
Open access: closed
Locations: Medicine & Science in Sports & Exercise (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
Keywords: right ventricular remodeling, endurance athletes, end-systolic wall stress, exercise-induced cardiac remodeling, right ventricle, left ventricle, pulmonary hypertension, training load, cardiac magnetic resonance, exercise echocardiography, pulmonary artery pressure, right ventricular mass, wall thickening, Laplace law, athlete's heart
MeSH terms: Adult, Physical Exertion, Female, Heart Ventricles, Humans, Male, Oxygen Consumption, Stroke Volume, Systole, Exercise, Case-Control Studies, Ventricular Function, Left, Ventricular Function, Right, Ultrasonography, Doppler, Magnetic Resonance Imaging, Cine, Ventricular Remodeling, Athletes

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Disproportionate Exercise Load and Remodeling of the Athlete's Right Ventricle

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