Impact of Smoking Status on Long-Term Mortality in Patients With Acute Myocardial Infarction
Open accessAbstract
BACKGROUND: Cessation of smoking after a cardiovascular event has been shown in Western countries to have a beneficial effect on clinical events during long-term follow-up. However, knowledge of the effect of smoking status after acute myocardial infarction (AMI) on the long-term mortality based on a large-scale sample is still limited in Japan. METHODS AND RESULTS: In the present study 2,579 AMI patients were enrolled in the Osaka Acute Coronary Insufficiency Study (OACIS) between April 1998 and March 2003. Smoking status was assessed at baseline and 3 months after hospital discharge by mailed questionnaire. Patients were divided into nonsmokers (n=823), former smokers (those who had stopped smoking before AMI onset, n=332), quitters (those who stopped smoking after AMI onset, n=1,056), and persistent smokers (those who smoked before and after AMI, n=368). Quitters had lower long-term mortality rates than persistent smokers (3.0% vs 5.2%; log rank, p=0.032). Multivariate Cox regression analysis revealed that smoking cessation was independently associated with a reduction in risk of long-term mortality (hazard ratio, 0.39; 95% confidence interval, 0.20-0.77). CONCLUSIONS: Patients who continue to smoke after AMI are at greater risk for death than patients who quit smoking. Cessation of smoking benefits the long-term prognosis in patients with AMI.
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Many epidemiological studies have reported that regardless of age and gender, the risk of recurrence of cardiovascular events decreases by approximately half after the first year of smoking cessation and continues to decrease thereafter.
“Many epidemiological studies have reported that regardless of age and gender, the risk of recurrence of cardiovascular events decreases by approximately half after the first year of smoking cessation and continue to decrease thereafter.”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [783]
In patients with CAD who continue to smoke, the risk of recurrence of cardiovascular events is higher than that observed in nonsmokers.
“In patients with CAD who continue to smoke, the risk of recurrence of cardiovascular events is higher than that observed in nonsmokers.”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [783]
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Kinoshita, M., Yokote, K., Arai, H., Iida, M., Ishigaki, Y., Ishibashi, S., Umemoto, S., Egusa, G., Ohmura, H., Okamura, T., et al. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2017 · Cited by 813 · see citing works
- Authors
- Kinjo, K., Sato, H., Sakata, Y., Nakatani, D., Mizuno, H., Shimizu, M., Sasaki, T., Kijima, Y., Nishino, M., Uematsu, M., Tanouchi, J., Nanto, S., Otsu, K., Hori, M., & on Behalf of the Osaka Acute Coronary Insufficiency Study (OACIS) Group
- Affiliations
- The University of Osaka (JP)
- Osaka Kosei Nenkin Hospital
- Higashi Osaka City General Hospital (JP)
- Osaka Rosai Hospital (JP)
- Kansai Rosai Hospital (JP)
- ORCID
- Venue
- Circulation Journal
- Publisher
- Japanese Circulation Society
- Published
- 2005
- Volume
- 69
- Issue
- 1
- Pages
- 7-12
- ISSN
- 1346-9843 (ISSN-L)
- 1347-4820
- OpenAlex
- W2058888760
- Cited by
- 59
- References
- 39
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 1 · 2018: 2 · 2017: 1 · 2016: 4 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 3
- FWCI
- 2.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (15590743)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- smoking cessation, acute myocardial infarction, long-term mortality, smoking status, former smokers, prognosis
- MeSH terms
- Angina Pectoris, Coronary Artery Disease, Diabetes Mellitus, Female, Humans, Hyperlipidemias, Hypertension, Japan, Male, Middle Aged, Myocardial Infarction, Risk Factors, Smoking, Survival Analysis
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