One-Year Cardiovascular Event Rates in Japanese Outpatients With Myocardial Infarction, Stroke, and Atrial Fibrillation: – Results From the Japan Thrombosis Registry for Atrial Fibrillation, Coronary, or Cerebrovascular Events (J-TRACE) –
Open accessAbstract
BACKGROUND: There remains uncertainty about the risk of cardiovascular events in stable outpatients with a history of myocardial infarction (MI), stroke, and atrial fibrillation in Japan. METHODS AND RESULTS: In the Japan Thrombosis Registry for Atrial Fibrillation, Coronary, or Cerebrovascular Events (J-TRACE), a nationwide prospective cohort of stable outpatients with a history of MI (n=2,291), stroke (n=3,554), and/or atrial fibrillation (n=2,242), 1-year follow-up data were available for 7,513 of 8,087 patients (follow-up rate: 92.9%). The primary endpoint (death/MI/stroke) was reported in 3.53 events per 100 person-years (95% confidence interval [CI]: 3.11-3.99) within 1 year. The rates of all-cause death, death from stroke, and death from MI within 1 year were 1.35 (95%CI: 1.10-1.65), 0.15 (95%CI: 0.08-0.27), and 0.06 (95%CI: 0.02-0.14) per 100 person-years, respectively. The rate of non-fatal stroke was 1.85 (95%CI: 1.55-2.19), while that of non-fatal MI was 0.33 (95%CI: 0.21-0.49). The rate of non-fatal stroke was highest among stroke patients (2.95; 95%CI: 2.39-3.60 per 100 person-years), while that of non-fatal MI was similar across all disease categories. Investigator-decided serious non-fatal bleeding events occurred in 0.21 events (95%CI: 0.12-0.34) per 100 person-years. CONCLUSIONS: In this large, nationwide Japanese registry, the highest stroke event rate was seen in patients with a history of stroke.
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In Japan, the 1-year incidence rate for patients with a history of stroke is 0.40-0.45% (4.0-4.5 people/1,000 person-years).
“In Japan, there has been reports revealing that the 1-year incidence rate for patients with a history of stroke is 0.40–0.45% (4.0–4.5 people/1,000 person-years)184, 185).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [184]
The risk of developing cerebrovascular disease is higher than the risk of CAD in those with a history of PAD.
“Moreover, the risk of developing cerebrovascular disease is also higher than the risk of CAD in those with a history of PAD184).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [184]
A history of noncardiogenic cerebral infarction is a high-risk condition for cerebrovascular disease and CAD.
“A history of noncardiogenic cerebral infarction is a high-risk condition for cerebrovascular disease and CAD.”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [184]
Patients with a history of cerebrovascular disease are a high-risk group for CAD.
“Patients with a history of cerebrovascular disease are known to be a high-risk group for CAD.”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [184]
The incidence rate of cerebrovascular disease is higher than the recurrence rate of CAD in patients with a history of CAD.
“On the other hand, it has been reported that the incidence rate of cerebrovascular disease is higher than the recurrence rate of CAD in patients with a history of CAD.”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [184]
PAD causes CAD and cerebrovascular disease to occur easily at high incidence rates.
“[Statement]PAD causes CAD and cerebrovascular disease to occur easily at high incidence rates. (Evidence level: E-1b)”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [184]
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Cited by
Sorted by citations
Kinoshita, M., Yokote, K., Arai, H., Iida, M., Ishigaki, Y., Ishibashi, S., Umemoto, S., Egusa, G., Ohmura, H., Okamura, T., et al. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2017 · Cited by 813 · see citing works
- Authors
- Goto, S., Ikeda, Y., Shimada, K., Uchiyama, S., Origasa, H., Kobayashi, H., & The J-TRACE Investigators
- Affiliations
- Tokai University (JP)
- Waseda University (JP)
- Jichi Medical University (JP)
- Tokyo Women's Medical University (JP)
- University of Toyama (JP)
- Venue
- Circulation Journal
- Publisher
- Japanese Circulation Society
- Published
- 2011
- Volume
- 75
- Issue
- 11
- Pages
- 2598-2604
- ISSN
- 1346-9843 (ISSN-L)
- 1347-4820
- OpenAlex
- W2315338663
- Cited by
- 35
- References
- 37
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 6 · 2012: 4
- FWCI
- 3.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Keywords
- cardiovascular events, myocardial infarction, stroke, atrial fibrillation, secondary prevention, all-cause mortality, non-fatal stroke, nonfatal myocardial infarction, bleeding events, stable outpatients, Japanese patients
- MeSH terms
- Aged, Aged, 80 and over, Atrial Fibrillation, Female, Follow-Up Studies, Humans, Japan, Male, Middle Aged, Myocardial Infarction, Registries, Thrombosis, Survival Rate, Stroke
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