5-HT1A-Receptor Subtype Mediates the Effect of Fluvoxamine, a Selective Serotonin Reuptake Inhibitor, on Marble-Burying Behavior in Mice
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The effect of fluvoxamine, a selective serotonin (5-HT) reuptake inhibitor, was studied in a model of anxiety and/or obsessive compulsive disorder (OCD) in mice. In the anxiety/OCD model, marble-burying behavior, marble-burying was significantly suppressed by fluvoxamine at 30 and 60 mg/kg, p.o. and the monoamine reuptake inhibitor clomipramine, at 60 mg/kg, p.o. No suppressive effect, however, was observed by the selective norepinephrine reuptake inhibitor desipramine at doses from 15 to 60 mg/kg, p.o. Suppressive effects were obtained by the serotonergic anxiolytic buspirone at 30 and 60 mg/kg, p.o. and the benzodiazepine anxiolytic diazepam at 10 mg/kg, p.o. The effect of fluvoxamine on marble-burying was slightly attenuated after repeated administration. On the other hand, both the effects of buspirone and diazepam completely disappeared after repeated administration. Effect of fluvoxamine on the marble-burying was unaffected by the 5-HT2 antagonist ritanserin. However, the 5-HT1A antagonist NAN-190 (1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl] piperazine) inhibited the suppressive effect of fluvoxamine on the marble-burying. From these results, the 5-HT1A-receptor subtype may be involved in the suppressive effect of fluvoxamine on the marble-burying, but the 5-HT2-receptor subtype is not involved in this effect.
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The marble-burying test has been shown to be responsive to clinically relevant medications for anxiety disorders, including anxiolytics such as chlordiazepoxide and antidepressants such as fluoxetine.
“the marble-burying test has been shown to be responsive to clinically relevant medications for anxiety disorders, both anxiolytics such as chlordiazepoxide and antidepressants such as fluoxetine”
From Parallel Anxiolytic-Like Effects and Upregulation of Neuronal Nicotinic Acetylcholine Receptors Following Chronic Nicotine and Varenicline (2011) · cites this paper as Ichimaru et al., 1995
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- Authors
- Ichimaru, Y., Egawa, T., & Sawa, A.
- Affiliations
- Meiji Seika Pharma Co., Ltd. (Japan) (JP)
- ORCID
- Egawa, Takashi
- Venue
- Japanese Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 1995
- Volume
- 68
- Issue
- 1
- Pages
- 65-70
- ISSN
- 0021-5198 (ISSN-L)
- OpenAlex
- W2071517122
- Cited by
- 163
- References
- 14
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 8 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 7 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 8 · 2015: 6 · 2014: 9 · 2013: 7 · 2012: 11
- FWCI
- 0.40
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- The Japanese Journal of Pharmacology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- fluvoxamine, 5-HT1A receptor, marble-burying behavior, obsessive-compulsive disorder, anxiety, selective serotonin reuptake inhibitors, NAN-190, 5-HT2 receptor, clomipramine, buspirone, diazepam, desipramine, serotonin
- MeSH terms
- Analysis of Variance, Animals, Antidepressive Agents, Behavior, Animal, Disease Models, Animal, Dose-Response Relationship, Drug, Male, Mice, Inbred ICR, Receptors, Serotonin, Time Factors, Anti-Anxiety Agents, Fluvoxamine, Receptors, Serotonin, 5-HT1, Mice
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