The selective metabotropic glutamate 2/3 receptor agonist MGS0028 reverses isolation rearing-induced abnormal behaviors in mice
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Isolation-induced abnormal behaviors are useful animal models for assessing potential anti-psychotic drugs. This study examined the effect of MGS0028, a selective metabotropic glutamate 2/3 receptor agonist, on abnormal behaviors such as hyperactivity, aggression, and deficits of prepulse inhibition in isolation-reared mice. MGS0028 attenuated hyperactivity and aggressive behaviors in isolation-reared mice. The agonist also reversed isolation rearing-induced deficits of prepulse inhibition. On the other hand, MGS0028 did not affect locomotor activity and prepulse inhibition in group-reared mice. These results suggest that the metabotropic glutamate 2/3 receptor agonist, MGS0028, is a potential compound for the treatment of psychiatric disorders.
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A Group II agonist attenuates aggressive tendencies, hyperactivity, and deficits in the inhibition of the startle response of mice reared in isolation.
“Yet another Group II agonist attenuates aggressive tendencies, hyperactivity, and deficits in the inhibition of the startle response of mice reared in isolation (Ago et al., 2012).”
From Glutamate receptors in domestication and modern human evolution (2020) · cites this paper as Ago et al., 2012
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The neurobiological basis of human aggression: A review on genetic and epigenetic mechanisms
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- Authors
- Ago, Y., Araki, R., Yano, K., Kawasaki, T., Chaki, S., Nakazato, A., Onoe, H., Hashimoto, H., Baba, A., Takuma, K., & Matsuda, T.
- Affiliations
- The University of Osaka (JP)
- RIKEN (JP)
- Taisho Pharmaceutical (Japan) (JP)
- Kanazawa University (JP)
- Hyogo University of Health Sciences (JP)
- ORCID
- Venue
- Journal of Pharmacological Sciences
- Publisher
- Japanese Pharmacological Society
- Published
- 2012
- Volume
- 118
- Issue
- 2
- Pages
- 295-298
- ISSN
- 1347-8613 (ISSN-L)
- 1347-8648
- OpenAlex
- W2034237738
- Cited by
- 29
- References
- 16
- Citations by year
- 2024: 2 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 7 · 2015: 5 · 2014: 2 · 2013: 5 · 2012: 2
- FWCI
- 1.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Pharmacological Sciences (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Japan Society for the Promotion of Science
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- isolation rearing, abnormal behavior, hyperactivity, aggression, prepulse inhibition, mental illness, social isolation
- MeSH terms
- Animals, Behavior, Animal, Bridged Bicyclo Compounds, Dicarboxylic Acids, Male, Motor Activity, Reflex, Startle, Antipsychotic Agents, Receptors, Metabotropic Glutamate, Mice
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