Behavioural and neurochemical effects of post-weaning social isolation in rodents—Relevance to developmental neuropsychiatric disorders

Depression: a new animal model sensitive to antidepressant treatments

PORSOLT, R. D., LE PICHON, M., & JALFRE, M. (1977) · Nature · doi:10.1038/266730a0 · Cited by 4,451 · see citing works

Autoradiographic localization of dopamine D1 and D2 receptors in rat nucleus accumbens: Resistance to differential rearing conditions

Bardo, M. T., & Hammer, R. P. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90226-e · Cited by 3,229 · see citing works

A new one-trial test for neurobiological studies of memory in rats. 1: behavioral data

Ennaceur, A., & Delacour, J. (1988) · Behavioural Brain Research · doi:10.1016/0166-4328(88)90157-x · Cited by 3,223 · see citing works

Behavioural despair in rats: A new model sensitive to antidepressant treatments

Porsolt, R. D., Anton, G., Blavet, N., & Jalfre, M. (1978) · European Journal of Pharmacology · doi:10.1016/0014-2999(78)90118-8 · Cited by 3,138 · see citing works

Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review.

Moore, T. H., Zammit, S., Lingford-Hughes, A., Barnes, T. R., Jones, P. B., Burke, M., & Lewis, G. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61162-3 · Cited by 2,224 · see citing works

Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies

BRAFF, D. L., Geyer, M. A., & Swerdlow, N. R. (2001) · Psychopharmacology · doi:10.1007/s002130100810 · Cited by 1,701 · see citing works

Dissociation in prefrontal cortex of affective and attentional shifts

Dias, R., Robbins, T. W., & Roberts, A. C. (1996) · Nature · doi:10.1038/380069a0 · Cited by 1,527 · see citing works

Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review

Geyer, M. A., Krebs-Thomson, K., Braff, D. L., & Swerdlow, N. R. (2001) · Psychopharmacology · doi:10.1007/s002130100811 · Cited by 1,484 · see citing works

Medial Frontal Cortex Mediates Perceptual Attentional Set Shifting in the Rat

Birrell, J. M., & Brown, V. J. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04320.2000 · Cited by 1,421 · see citing works

Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates

Dalley, J. W., Cardinal, R. N., & Robbins, T. W. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.09.006 · Cited by 1,329 · see citing works

Gating and Habituation of the Startle Reflex in Schizophrenic Patients

Braff, D. L. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820030038005 · Cited by 1,027 · see citing works

Neuropsychopharmacology: The Fifth Generation of Progress

Sagduyu, K. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.7.1251-a · Cited by 1,023 · see citing works

The neurodevelopmental model of schizophrenia: update 2005

Rapoport, J. L., Addington, A. M., Frangou, S., & Psych, M. R. C. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001642 · Cited by 993 · see citing works

Self reported cannabis use as a risk factor for schizophrenia in Swedish conscripts of 1969: Historical cohort study

Zammit, S., Allebeck, P., Andreasson, S., Lundberg, I., & Lewis, G. (2002) · BMJ · doi:10.1136/bmj.325.7374.1199 · Cited by 871 · see citing works

Sex Differences in the Risk of Schizophrenia: Evidence From Meta-analysis

Aleman, A., Kahn, R. S., & Selten, J.-P. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.6.565 · Cited by 818 · see citing works

Neuropsychopharmacology : The Fifth Generation of Progress

Davis, K. L., Charney, D. S., Coyle, J. T., & Nemeroff, C. B. (2002) · Lippincott Williams & Wilkins eBooks · Cited by 747 · see citing works

To Model a Psychiatric Disorder in Animals Schizophrenia As a Reality Test

Lipska, B. K. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00137-8 · Cited by 650 · see citing works

Total social isolation in monkeys.

Harlow, H. F., Dodsworth, R. O., & Harlow, M. K. (1965) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.54.1.90 · Cited by 619 · see citing works

Delta-9-tetrahydrocannabinol effects in schizophrenia: Implications for cognition, psychosis, and addiction

D’Souza, D. C., Abi-Saab, W. M., Madonick, S., Forselius-Bielen, K., Doersch, A., Braley, G., Gueorguieva, R., Cooper, T. B., & Krystal, J. H. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.12.006 · Cited by 617 · see citing works

Using an Animal Model of Deficient Sensorimotor Gating to Study the Pathophysiology and New Treatments of Schizophrenia

Swerdlow, N. R., & Geyer, M. A. (1998) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033326 · Cited by 616 · see citing works

Differential Performance of Acute and Chronic Schizophrenics in a Latent Inhibition Task

Baruch, I., HEMSLEY, D. R., & Gray, J. A. (1988) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-198810000-00004 · Cited by 612 · see citing works

Stress, depression, and anhedonia: caveats concerning animal models

Anisman, H., & Matheson, K. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.007 · Cited by 569 · see citing works

Importance of studying the contributions of early adverse experience to neurobiological findings in depression

Heim, C., Plotsky, P. M., & Nemeroff, C. B. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300397 · Cited by 514 · see citing works

Effect of social isolation on stress-related behavioural and neuroendocrine state in the rat

Weiss, I. C., Pryce, C. R., Jongen-Rêlo, A. L., Nanz-Bahr, N. I., & Feldon, J. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.10.015 · Cited by 512 · see citing works

Behavioral, neurochemical and endocrinological characterization of the early social isolation syndrome

Heidbreder, C. A., Weiss, I. C., Domeney, A. M., Pryce, C., Homberg, J., Hedou, G., Feldon, J., Moran, M. C., & Nelson, P. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00336-5 · Cited by 404 · see citing works

Isolation rearing of rats produces a deficit in prepulse inhibition of acoustic startle similar to that in schizophrenia

Geyer, M. A., Wilkinson, L. S., Humby, T., & Robbins, T. W. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90180-l · Cited by 377 · see citing works

Schizophrenia-Relevant Behavioral Testing in Rodent Models: A Uniquely Human Disorder?

Powell, C. M., & Miyakawa, T. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.008 · Cited by 368 · see citing works

The effect of housing and gender on morphine self-administration in rats

ALEXANDER, B. K., Coambs, R. B., & Hadaway, P. F. (1978) · Psychopharmacology · doi:10.1007/bf00426903 · Cited by 356 · see citing works

A critical period for social isolation in the rat

Einon, D. F., & Morgan, M. J. (1977) · Developmental Psychobiology · doi:10.1002/dev.420100205 · Cited by 342 · see citing works

Dopaminergic and serotonergic function following isolation rearing in rats: study of behavioural responses and postmortem and in vivo neurochemistry

Jones, G. H., Hernandez, T. D., Kendall, D. A., Marsden, C. A., & Robbins, T. W. (1992) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(92)90635-s · Cited by 341 · see citing works

Decreased dendritic spine density on prefrontal cortical and hippocampal pyramidal neurons in postweaning social isolation rats

Silva-Gómez, A. B., Rojas, D., Juárez, I., & Flores, G. (2003) · Brain Research · doi:10.1016/s0006-8993(03)03042-7 · Cited by 336 · see citing works

Psychosis pathways converge via D2High dopamine receptors

Seeman, P. M., Schwarz, J., Chen, J., Szechtman, H., Perreault, M. L., McKnight, G. S., Roder, J., Quirion, R., Boksa, P., Srivastava, L. K., et al. (2006) · Synapse · doi:10.1002/syn.20303 · Cited by 328 · see citing works

Information-processing deficits and thought disorder in schizophrenia

Perry, W., & BRAFF, D. L. (1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.3.363 · Cited by 311 · see citing works

Influence of Postweaning Social Isolation in the Rat on Brain Development, Conditioned Behavior, and Neurotransmission

Lapiz, M. D. S., Fulford, A., Muchimapura, S., Mason, R., Parker, T., & Marsden, C. A. (2003) · Neuroscience and Behavioral Physiology · doi:10.1023/a:1021171129766 · Cited by 305 · see citing works

Female rats are more vulnerable than males in an animal model of depression: the possible role of serotonin

Kennett, G. A., Chaouloff, F., Marcou, M., & Curzon, G. (1986) · Brain Research · doi:10.1016/0006-8993(86)91355-7 · Cited by 301 · see citing works

Dissociable effects of isolation rearing and environmental enrichment on exploration, spatial learning and HPA activity in adult rats

Schrijver, N. C. A., Bahr, N. I., Weiss, I. C., & Würbel, H. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00790-6 · Cited by 294 · see citing works

The effects of psychomotor stimulants on stereotypy and locomotor activity in socially-deprived and control rats

Sahakian, B. J., Robbins, T. W., Morgan, M. J., & Iversen, S. D. (1975) · Brain Research · doi:10.1016/0006-8993(75)90975-0 · Cited by 278 · see citing works

Effect of environmental stressors on opiate and psychostimulant reinforcement, reinstatement and discrimination in rats: a review

Lü, L., Shepard, J. D., Hall, F. S., & Shaham, Y. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(03)00073-3 · Cited by 277 · see citing works

Relations between brain chemistry and problem-solving among rats raised in enriched and impoverished environments.

Krech, D., Rosenzweig, M. R., & Bennett, E. L. (1962) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0044220 · Cited by 271 · see citing works

Social Isolation in the Rat Produces Developmentally Specific Deficits in Prepulse Inhibition of the Acoustic Startle Response Without Disrupting Latent Inhibition

Wilkinson, L. S., Killcross, S., Humby, T., Hall, F. S., Geyer, M. A., & Robbins, T. W. (1994) · Neuropsychopharmacology · doi:10.1038/npp.1994.8 · Cited by 267 · see citing works

Neuropsychological evidence for frontostriatal dysfunction in schizophrenia

Elliott, R., McKenna, P. J., Robbins, T. W., & Sahakian, B. J. (1995) · Psychological Medicine · doi:10.1017/s0033291700033523 · Cited by 267 · see citing works

Isolation rearing in rats: pre- and postsynaptic changes in striatal dopaminergic systems

Hall, F. S., Wilkinson, L. S., Humby, T., Inglis, W., Kendall, D. A., Marsden, C. A., & Robbins, T. W. (1998) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(97)00510-8 · Cited by 261 · see citing works

Latent inhibition in drug naive schizophrenics: relationship to duration of illness and dopamine D2 binding using SPET

Gray, N. S., Pilowsky, L. S., Gray, J. A., & Kerwin, R. W. (1995) · Schizophrenia Research · doi:10.1016/0920-9964(95)00034-j · Cited by 248 · see citing works

Modification of hippocampal neurogenesis and neuroplasticity by social environments

Lü, L., Bao, G., Chen, H., Xia, P., Fan, X., Zhang, J., Pei, G., & Ma, L. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00248-6 · Cited by 238 · see citing works

The “isolation syndrome” in mice

Valzelli, L. (1973) · Psychopharmacologia · doi:10.1007/bf00421275 · Cited by 237 · see citing works

Locomotor activity, defecation score and corticosterone levels during an openfield exposure: A comparison among individually and group-housed rats, and genetically selected rat lines

Gentsch, C., Lichtsteiner, M., & Feer, H. (1981) · Physiology & Behavior · doi:10.1016/0031-9384(81)90320-6 · Cited by 233 · see citing works

Increased sensitivity to amphetamine and reward-related stimuli following social isolation in rats: possible disruption of dopamine-dependent mechanisms of the nucleus accumbens

Jones, G. H., Marsden, C. A., & Robbins, T. W. (1990) · Psychopharmacology · doi:10.1007/bf02244105 · Cited by 232 · see citing works

Examination of drug-induced and isolation-induced disruptions of prepulse inhibition as models to screen antipsychotic drugs

Varty, G. B., Higgins, G. A., & Higgins, G. A. (1995) · Psychopharmacology · doi:10.1007/bf02246437 · Cited by 231 · see citing works

Molecular Targets for Treating Cognitive Dysfunction in Schizophrenia

Gray, J. A., & Roth, B. L. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm074 · Cited by 225 · see citing works

Environmental enrichment and isolation rearing in the rat: effects on locomotor behavior and startle response plasticity

Varty, G. B., Paulus, M. P., BRAFF, D. L., & Geyer, M. A. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00269-3 · Cited by 211 · see citing works

Social isolation increases aggressive behaviour and alters the effects of diazepam in the rat social interaction test

Wongwitdecha, N., & Marsden, C. A. (1996) · Behavioural Brain Research · doi:10.1016/0166-4328(96)00181-7 · Cited by 210 · see citing works

Cocaine self-administration in rats influenced by environmental conditions: implications for the etiology of drug abuse

Schenk, S., Lacelle, G., Gorman, K., & Amit, Z. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)91003-2 · Cited by 207 · see citing works

GABAergic projection from nucleus accumbers to ventral pallidum mediates dopamine-induced sensorimotor gating deficits of acoustic startle in rats

Swerdlow, N. R., BRAFF, D. L., & Geyer, M. A. (1990) · Brain Research · doi:10.1016/0006-8993(90)91754-5 · Cited by 206 · see citing works

Genetic animal models: focus on schizophrenia

Gainetdinov, R. R., Mohn, A. R., & Caron, M. G. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01886-5 · Cited by 201 · see citing works

Environmental animal models for sensorimotor gating deficiencies in schizophrenia: a review

Weiss, I. C., & Feldon, J. (2001) · Psychopharmacology · doi:10.1007/s002130100800 · Cited by 194 · see citing works

Isolation rearing induces recognition memory deficits accompanied by cytoskeletal alterations in rat hippocampus

Bianchi, M., Fone, K. C. F., Azmi, N., Heidbreder, C. A., Hagan, J. J., & Marsden, C. A. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05170.x · Cited by 191 · see citing works

Adolescent enrichment partially reverses the social isolation syndrome

Hellemans, K. G. C., Benge, L. C., & Olmstead, M. C. (2004) · Developmental Brain Research · doi:10.1016/j.devbrainres.2004.03.003 · Cited by 189 · see citing works

Specific abnormalities in serotonin release in the prefrontal cortex of isolation-reared rats measured during behavioural performance of a task assessing visuospatial attention and impulsivity

Dalley, J. W., Theobald, D. E. H., Pereira, E., Li, P., & Robbins, T. W. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1215-y · Cited by 184 · see citing works

Long-lasting changes in behavioural and neuroendocrine indices in the rat following neonatal maternal separation: Gender-dependent effects

Slotten, H. A., Kalinichev, M., Hagan, J. J., Marsden, C. A., & Fone, K. C. F. (2006) · Brain Research · doi:10.1016/j.brainres.2006.04.066 · Cited by 179 · see citing works

Resocialisation of isolation-reared rats does not alter their anxiogenic profile on the elevated X-maze model of anxiety

Wright, I. K., Upton, N., & Marsden, C. A. (1991) · Physiology & Behavior · doi:10.1016/0031-9384(91)90572-6 · Cited by 177 · see citing works

Weaning age, social isolation, and gender, interact to determine adult explorative and social behavior, and dendritic and spine morphology in prefrontal cortex of rats

Ferdman, N., MURMU, R., Bock, J., Braun, K., & Leshem, M. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.03.011 · Cited by 173 · see citing works

Behavioural rigidity and rule-learning deficits following isolation-rearing in the rat: neurochemical correlates

Jones, G. H., Marsden, C. A., & Robbins, T. W. (1991) · Behavioural Brain Research · doi:10.1016/s0166-4328(05)80050-6 · Cited by 172 · see citing works

“Isolation stress” revisited: isolation-rearing effects depend on animal care methods

Holson, R. R., Scallet, A. C., Ali, S. F., & Turner, B. B. (1991) · Physiology & Behavior · doi:10.1016/0031-9384(91)90338-o · Cited by 166 · see citing works

Environmental enrichment attenuates locomotor sensitization, but not in vitro dopamine release, induced by amphetamine

Bardo, M. T., Bowling, S. L., Rowlett, J. K., Manderscheid, P. Z., Buxton, S. T., & Dwoskin, L. P. (1995) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)00413-d · Cited by 159 · see citing works

Isolation syndrome in the rat

Hatch, A., Wiberg, G., Zawidzka, Z., Cann, M. C., Airth, J. M., & Grice, H. C. (1965) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(65)90132-8 · Cited by 158 · see citing works

Effects of post-weaning environment on learning in the rat

Morgan, M. J. (1973) · Animal Behaviour · doi:10.1016/s0003-3472(73)80002-8 · Cited by 156 · see citing works

Leftward shift in the acquisition of cocaine self-administration in isolation-reared rats: relationship to extracellular levels of dopamine, serotonin and glutamate in the nucleus accumbens and amygdala-striatal FOS expression

Howes, S. R., Dalley, J. W., Morrison, C. H., Robbins, T. W., & Everitt, B. J. (2000) · Psychopharmacology · doi:10.1007/s002130000451 · Cited by 156 · see citing works

Deficits in parvalbumin and calbindin immunoreactive cells in the hippocampus of isolation reared rats

Harte, M., Powell, S. B., Swerdlow, N. R., Geyer, M. A., & Reynolds, G. P. (2007) · Journal of Neural Transmission · doi:10.1007/s00702-007-0627-6 · Cited by 146 · see citing works

Double dissociation of social and environmental stimulation on spatial learning and reversal learning in rats

Schrijver, N. C., Pallier, P. N., Brown, V. J., & Würbel, H. (2003) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.10.016 · Cited by 143 · see citing works

Increased Density of Multiple-Head Dendritic Spines on Medium-Sized Spiny Neurons of the Striatum in Rats Reared in a Complex Environment

Comery, T. A., Stamoudis, C. X., Irwin, S. A., & Greenough, W. T. (1996) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1996.0049 · Cited by 142 · see citing works

Social isolation-induced changes in the hypothalamic–pituitary–adrenal axis in the rat

Serra, M., Pisu, M. G., Floris, I., & Biggio, G. (2005) · Stress · doi:10.1080/10253890500495244 · Cited by 142 · see citing works

Free choice ethanol intake of laboratory rats under different social conditions

Wolffgramm, J. (1990) · Psychopharmacology · doi:10.1007/bf02244132 · Cited by 139 · see citing works

Reversal of Isolation Rearing-Induced Deficits in Prepulse Inhibition by Seroquel and Olanzapine

Bakshi, V. P., Swerdlow, N. R., Braff, D. L., & Geyer, M. A. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00246-1 · Cited by 135 · see citing works

Effect of isolation on brain monoamines and the behavior of mice in tests of exploration, locomotion, anxiety and behavioral ‘despair’

Hilakivi, L. A., Ota, M., & Lister, R. G. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90516-9 · Cited by 135 · see citing works

Behavioural and neurochemical effects of early social deprivation in the rat

Robbins, T. W., Jones, G. H., & Wilkinson, L. S. (1996) · Journal of Psychopharmacology · doi:10.1177/026988119601000107 · Cited by 135 · see citing works

Influence of housing conditions on the acquisition of intravenous heroin and cocaine self-administration in rats

Bozarth, M. A., Murray, A., & Wise, R. A. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90490-5 · Cited by 134 · see citing works

Increased 5-HT2C receptor responsiveness occurs on rearing rats in social isolation

Fone, K. C. F., Shalders, K., Fox, Z. D., Arthur, R., & Marsden, C. A. (1996) · Psychopharmacology · doi:10.1007/bf02246645 · Cited by 133 · see citing works

Medial prefrontal cortex volume loss in rats with isolation rearing-induced deficits in prepulse inhibition of acoustic startle

Day-Wilson, K. M., Jones, D. N. C., Southam, E., Cilia, J., & Totterdell, S. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.04.048 · Cited by 129 · see citing works

Isolation-induced locomotor hyperactivity and hypoalgesia in rats are prevented by handling and reversed by resocialization

Gentsch, C., Lichtsteiner, M., Frischknecht, H. R., Feer, H., & Siegfried, B. (1988) · Physiology & Behavior · doi:10.1016/0031-9384(88)90091-1 · Cited by 128 · see citing works

From an animal model of an attentional deficit towards new insights into the pathophysiology of schizophrenia

Feldon, J., & Weiner, I. (1992) · Journal of Psychiatric Research · doi:10.1016/0022-3956(92)90040-u · Cited by 125 · see citing works

Isolation rearing enhances the locomotor response to cocaine and a novel environment, but impairs the intravenous self-administration of cocaine

Phillips, G. D., Howes, S. R., Whitelaw, R. B., Wilkinson, L. S., Robbins, T. W., & Everitt, B. J. (1994) · Psychopharmacology · doi:10.1007/bf02245084 · Cited by 123 · see citing works

Reduced latent inhibition in people with schizophrenia: an effect of psychosis or of its treatment

Williams, J. H., Wellman, N. A., Geaney, D. P., Cowen, P. J., Feldon, J., & Rawlins, J. N. P. (1998) · The British Journal of Psychiatry · doi:10.1192/bjp.172.3.243 · Cited by 123 · see citing works

Social isolation selectively reduces hippocampal brain-derived neurotrophic factor without altering plasma corticosterone

Scaccianoce, S., Bianco, P. D., Paolone, G., Caprioli, D., Modafferi, A. M. E., Nencini, P., & Badiani, A. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.04.024 · Cited by 122 · see citing works

Psychopharmacological approaches to modulating attention in the five-choice serial reaction time task: implications for schizophrenia

Chudasama, Y., & Robbins, T. W. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1805-y · Cited by 121 · see citing works

DOI disrupts prepulse inhibition of startle in rats via 5-HT2A receptors in the ventral pallidum

Sipes, T. E., & Geyer, M. A. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00316-8 · Cited by 118 · see citing works

Social isolation attenuates rat forebrain 5-HT release induced by KCl stimulation and exposure to a novel environment

Bickerdike, M. J., Wright, I. K., & Marsden, C. A. (1993) · Behavioural Pharmacology · doi:10.1097/00008877-199306000-00005 · Cited by 117 · see citing works

The effect of housing and gender on preference for morphine-sucrose solutions in rats

Hadaway, P. F., ALEXANDER, B. K., Coambs, R. B., & Beyerstein, B. L. (1979) · Psychopharmacology · doi:10.1007/bf00431995 · Cited by 116 · see citing works

The socially-isolated rat as a model for anxiety

Parker, V., & Morinan, A. (1986) · Neuropharmacology · doi:10.1016/0028-3908(86)90224-8 · Cited by 113 · see citing works

Ontogeny of Isolation Rearing-Induced Deficits in Sensorimotor Gating in Rats

Bakshi, V. P., & Geyer, M. A. (1999) · Physiology & Behavior · doi:10.1016/s0031-9384(99)00082-7 · Cited by 113 · see citing works

Age-dependent effects of isolation housing on the self-administration of ethanol in laboratory rats

Schenk, S., Gorman, K., & Amit, Z. (1990) · Alcohol · doi:10.1016/0741-8329(90)90090-y · Cited by 110 · see citing works

Differential Rearing Alters Spine Density on Medium-Sized Spiny Neurons in the Rat Corpus Striatum: Evidence for Association of Morphological Plasticity with Early Response Gene Expression

Comery, T. A., Shah, R., & Greenough, W. T. (1995) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1995.1025 · Cited by 110 · see citing works

Strain differences in the isolation-induced effects on prepulse inhibition of the acoustic startle response and on locomotor activity.

Weiss, I. C., Iorio, L. D., Feldon, J., & Domeney, A. M. (2000) · Behavioral Neuroscience · doi:10.1037/0735-7044.114.2.364 · Cited by 109 · see citing works

Effects of isolation-rearing on voluntary consumption of ethanol, sucrose and saccharin solutions in Fawn Hooded and Wistar rats

Hall, F. S., Huang, S., Pert, A., Linnoila, M., & Fong, G. W. (1998) · Psychopharmacology · doi:10.1007/s002130050706 · Cited by 104 · see citing works

Impoverished Rearing Environment Alters Metabotropic Glutamate Receptor Expression and Function in the Prefrontal Cortex

Melendez, R. I., Lee Gregory, M., Bardo, M. T., & Kalivas, P. W. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300507 · Cited by 104 · see citing works

Impairment on the hippocampal-dependent virtual Morris water task in schizophrenia

Hanlon, F. M., Weisend, M. P., Hamilton, D. A., Jones, A. P., Thoma, R. J., Huang, M., Martin, K., Yeo, R. A., Miller, G. A., & Cañive, J. M. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.05.021 · Cited by 103 · see citing works

Gender-specific effects of social housing in rats after chronic mild stress exposure

Westenbroek, C. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(02)00310-x · Cited by 102 · see citing works

Effects of isolation-rearing on locomotion, anxiety and responses to ethanol in Fawn Hooded and Wistar rats

Hall, F. S., Huang, S., Fong, G., Pert, A., & Linnoila, M. (1998) · Psychopharmacology · doi:10.1007/s002130050705 · Cited by 102 · see citing works

Long-term evaluation of isolation-rearing induced prepulse inhibition deficits in rats

Cilia, J., Reavill, C. A., Hagan, J. J., & Jones, D. N. C. (2001) · Psychopharmacology · doi:10.1007/s002130100786 · Cited by 102 · see citing works

Effects of isolation rearing on startle reactivity, habituation, and prepulse inhibition in male Lewis, Sprague-Dawley, and Fischer F344 rats.

Varty, G. B., & Geyer, M. A. (1998) · Behavioral Neuroscience · doi:10.1037//0735-7044.112.6.1450 · Cited by 100 · see citing works

Effect of isolation rearing on 5-HT agonist-induced responses in the rat

Wright, I. K., Ismail, H., Upton, N., & Marsden, C. A. (1991) · Psychopharmacology · doi:10.1007/bf02244319 · Cited by 99 · see citing works

The Effects of Isolation Rearing on Behavioural Inhibition in the Rat

Morgan, M. J., Einon, D. F., & Nicholas, D. (1975) · Quarterly Journal of Experimental Psychology · doi:10.1080/14640747508400524 · Cited by 97 · see citing works

The effects of isolation rearing on exploration in the rat

Sahakian, B. J., Robbins, T. W., & Iversen, S. D. (1977) · Animal Learning & Behavior · doi:10.3758/bf03214077 · Cited by 97 · see citing works

Effects of social isolation rearing on learning in the morris water maze

Wongwitdecha, N., & Marsden, C. A. (1996) · Brain Research · doi:10.1016/0006-8993(95)01578-7 · Cited by 96 · see citing works

Episodic memory and neuroimaging of hippocampus and fornix in chronic schizophrenia

Nestor, P. G., Kubicki, M. R., Kuroki, N., Gurrera, R. J., Niznikiewicz, M. A., Shenton, M. E., & McCarley, R. W. (2007) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2006.12.020 · Cited by 95 · see citing works

Biochemical and behavioural changes induced by isolation in rats

Valzelli, L., & Garattini, S. K. (1972) · Neuropharmacology · doi:10.1016/0028-3908(72)90052-4 · Cited by 95 · see citing works

Isolation-rearing enhances tail pinch-induced oral behavior in rats

Sahakian, B. J., & Robbins, T. W. (1977) · Physiology & Behavior · doi:10.1016/0031-9384(77)90093-2 · Cited by 93 · see citing works

Effect of Isolation‐Rearing on Conditioned Dopamine Release In Vivo in the Nucleus Accumbens of the Rat

Fulford, A. J., & Marsden, C. A. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70010384.x · Cited by 93 · see citing works

The Disruption of Prepulse Inhibition by Social Isolation in the Wistar Rat: How Robust Is the Effect?

Domeney, A. M., & Feldon, J. (1998) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(97)00534-0 · Cited by 92 · see citing works

Dissociation between the effects of pre-weaning and/or post-weaning social isolation on prepulse inhibition and latent inhibition in adult Sprague–Dawley rats

Weiss, I. C., Domeney, A. M., Moreau, J., Russig, H. D., & Feldon, J. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00166-8 · Cited by 91 · see citing works

Isolation rearing impairs the reinforcing efficacy of intravenous cocaine or intra-accumbensd-amphetamine: impaired response to intra-accumbens D1 and D2/D3 dopamine receptor antagonists

Phillips, G. D., Howes, S. R., Whitelaw, R. B., Robbins, T. W., & Everitt, B. J. (1994) · Psychopharmacology · doi:10.1007/bf02245085 · Cited by 90 · see citing works

Reduced synaptophysin immunoreactivity in the dentate gyrus of prepulse inhibition-impaired isolation-reared rats

Varty, G. B., Marsden, C. A., & Higgins, G. A. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01173-7 · Cited by 90 · see citing works

Region specific changes in forebrain 5-hydroxytryptamine1a and 5-hydroxytryptamine2a receptors in isolation-reared rats: an in vitro autoradiography study

Preece, M., Dalley, J. W., Theobald, D. E. H., Robbins, T. W., & Reynolds, G. P. (2003) · Neuroscience · doi:10.1016/j.neuroscience.2003.10.008 · Cited by 88 · see citing works

“Impoverished” rats weigh more than “Enriched” rats because they eat more

Fiala, B. A., Snow, F. M., & Greenough, W. T. (1977) · Developmental Psychobiology · doi:10.1002/dev.420100607 · Cited by 88 · see citing works

Effects of isolation rearing on startle reactivity, habituation, and prepulse inhibition in male Lewis, Sprague-Dawley, and Fischer F344 rats.

Varty, G. B., & Geyer, M. A. (1998) · Behavioral Neuroscience · doi:10.1037/0735-7044.112.6.1450 · Cited by 88 · see citing works

Differential Rearing Conditions Alter Operant Responding for Ethanol in Outbred Rats

Deehan, G. A., Cain, M. E., & Kiefer, S. W. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00466.x · Cited by 87 · see citing works

Premorbid Functioning in Schizophrenia: Relation to Baseline Symptoms, Treatment Response, and Medication Side Effects

Strous, R. D., Alvir, J. M. J., Robinson, D. G., Gal, G., Sheitman, B., Chakos, M., & Lieberman, J. A. (2004) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a007077 · Cited by 86 · see citing works

Different reaction patterns in individually and socially reared rats during exposures to novel environments

Gentsch, C., Lichtsteiner, M., Kräuchi, K., & Feer, H. (1982) · Behavioural Brain Research · doi:10.1016/0166-4328(82)90163-2 · Cited by 84 · see citing works

Increased responsiveness of dopamine to atypical, but not typical antipsychotics in the medial prefrontal cortex of rats reared in isolation

Heidbreder, C. A., Foxton, R. H., Cilia, J., Hughes, Z. A., Shah, A. J., Atkins, A. R., Hunter, J. A., Hagan, J. J., & Jones, D. N. C. (2001) · Psychopharmacology · doi:10.1007/s002130100760 · Cited by 84 · see citing works

Conditioned release of 5-hydroxytryptamine in vivo in the nucleus accumbens following isolation-rearing in the rat

Fulford, A. J., & Marsden, C. A. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00423-5 · Cited by 83 · see citing works

Long-term social isolation and medial prefrontal cortex: dopaminergic and cholinergic neurotransmission

Leng, A., Feldon, J., & Ferger, B. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2003.11.011 · Cited by 83 · see citing works

Influence of antipsychotic medication on pain perception in schizophrenia

Jochum, T., Letzsch, A., Greiner, W., Wagner, G., Sauer, H., & Bär, K. (2006) · Psychiatry Research · doi:10.1016/j.psychres.2005.09.004 · Cited by 83 · see citing works

Dopamine depletion of the nucleus accumbens reverses isolation-induced deficits in prepulse inhibition in rats

Powell, S. B., Geyer, M. A., Preece, M. A., Pitcher, L. K., Reynolds, G. P., & Swerdlow, N. R. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00122-2 · Cited by 82 · see citing works

Isolation rearing and hyperlocomotion are associated with reduced immediate early gene expression levels in the medial prefrontal cortex

Levine, J. B., Youngs, R. M., MacDonald, M. L., Chu, M. S., Leeder, A., Francois Berthiaume, B., & Konradi, C. L. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.11.063 · Cited by 81 · see citing works

Neuropsychological profile of cognitively impaired patients with schizophrenia

Bozikas, V. P., Kosmidis, M. H., Kiosseoglou, G., & Karavatos, A. (2006) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2005.05.002 · Cited by 81 · see citing works

Interaction between isolation rearing and social development on exploratory behavior in male rats

Arakawa, H. (2005) · Behavioural Processes · doi:10.1016/j.beproc.2005.07.002 · Cited by 79 · see citing works

Early social isolation, but not maternal separation, affects behavioral sensitization to amphetamine in male and female adult rats

Weiss, I. C., Domeney, A. M., Heidbreder, C. A., Moreau, J., & Feldon, J. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00626-8 · Cited by 79 · see citing works

An examination of heroin conditioning in preferred and nonpreferred environments and in differentially housed mature and immature rats

Schenk, S., Ellison, F. E., Hunt, T., & Amit, Z. (1985) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(85)90380-6 · Cited by 78 · see citing works

The effect of Δ9-tetrahydrocannabinol on sensorimotor gating in socially isolated rats

Malone, D. T., & TAYLOR, D. A. H. B. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.07.009 · Cited by 77 · see citing works

Effect of early rearing conditions on alcohol drinking and 5-HT1A receptor function in C57BL/6J mice

Advani, T., Hensler, J. G., & Koek, W. (2006) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145706007401 · Cited by 75 · see citing works

Isolation rearing in the rat disrupts the hippocampal response to stress

Muchimapura, S., Fulford, A. J., Mason, R. J., & Marsden, C. A. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00107-0 · Cited by 75 · see citing works

Inhibition and isolation rearing in the rat: Extinction and satiation

Morgan, M. K., Einon, D. F., & Morris, R. G. (1977) · Physiology & Behavior · doi:10.1016/0031-9384(77)90084-1 · Cited by 73 · see citing works

The Effects of Isolation-Rearing of Rats on Behavioural Responses to Food and Environmental Novelty

Hall, F. S., Humby, T., Wilkinson, L. S., & Robbins, T. W. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(97)00115-7 · Cited by 73 · see citing works

Enhanced Neurotensin Neurotransmission Is Involved in the Clinically Relevant Behavioral Effects of Antipsychotic Drugs: Evidence from Animal Models of Sensorimotor Gating

Binder, E. B., Kinkead, B. L., Owens, M. J., Kilts, C. D., & Nemeroff, C. B. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-02-00601.2001 · Cited by 73 · see citing works

Social isolation at weaning: Some effects on two measures of activity

Syme, L. A. (1973) · Animal Learning & Behavior · doi:10.3758/bf03199065 · Cited by 73 · see citing works

On the nature of Wisconsin Card Sorting Test performance in schizophrenia

Haut, M. W., Cahill, J., Cutlip, W. D., Stevenson, J. M., Makela, E. H., & Bloomfield, S. M. (1996) · Psychiatry Research · doi:10.1016/0165-1781(96)02940-x · Cited by 72 · see citing works

Isolation rearing of mice induces deficits in prepulse inhibition of the startle response

Varty, G. B., Powell, S. B., Masten, V. L., Buell, M. R., & Geyer, M. A. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.11.025 · Cited by 70 · see citing works

Early social deprivation disrupts attentional, but not affective, shifts in rats

Schrijver, N. C., & Würbel, H. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.2.437 · Cited by 70 · see citing works

Isolation rearing-induced disruption of prepulse inhibition

Weiss, I. C., Feldon, J., & Domeney, A. M. (1999) · Behavioural Pharmacology · doi:10.1097/00008877-199903000-00003 · Cited by 69 · see citing works

Hyperactivity to novelty induced by social isolation is not correlated with changes in D2 receptor function and binding in striatum

Arco, A. D., Zhu, S., Terasmaa, A., Mohammed, A. H. S., & Fuxé, K. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1578-8 · Cited by 69 · see citing works

Effect of isolation rearing on pre‐ and post‐synaptic serotonergic function in the rat dorsal hippocampus

Muchimapura, S., Mason, R. J., & Marsden, C. A. (2002) · Synapse · doi:10.1002/syn.10167 · Cited by 69 · see citing works

Effects of central noradrenaline depletion by the selective neurotoxin DSP-4 on the behaviour of the isolated rat in the elevated plus maze and water maze

Bluhm, M. D. L., Mateo, Y., Durkin, S., Parker, T. L., & Marsden, C. A. (2001) · Psychopharmacology · doi:10.1007/s002130100702 · Cited by 68 · see citing works

Isolation versus grouped housing in rats: Differential effects of low doses of heroin in the place preference paradigm

Schenk, S., Hunt, T., Colle, L. M., & Amit, Z. (1983) · Life Sciences · doi:10.1016/0024-3205(83)90118-2 · Cited by 68 · see citing works

Long-term evaluation of isolation-rearing induced prepulse inhibition deficits in rats: an update

Cilia, J., Hatcher, P. D., Reavill, C., & Jones, D. N. C. (2005) · Psychopharmacology · doi:10.1007/s00213-004-2139-5 · Cited by 68 · see citing works

The Effects of Isolation-Rearing on Preference by Rats for A Novel Environment

Hall, F. S., Humby, T., Wilkinson, L. S., & Robbins, T. W. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(97)00117-0 · Cited by 66 · see citing works

Is there a critical developmental `window' for isolation rearing-induced changes in prepulse inhibition of the acoustic startle response?

Varty, G. B., BRAFF, D. L., & Geyer, M. A. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(98)00129-6 · Cited by 66 · see citing works

Isolation-rearing retards the acquisition of schedule-induced polydipsia in rats

Jones, G. H., Robbins, T. W., & Marsden, C. A. (1989) · Physiology & Behavior · doi:10.1016/0031-9384(89)90167-4 · Cited by 65 · see citing works

Effects of noradrenaline depletion in the brain on response to novelty in isolation-reared rats

Bluhm, M. D. L., Mateo, Y., Parker, T. L., & Marsden, C. A. (2000) · Psychopharmacology · doi:10.1007/s002130000534 · Cited by 64 · see citing works

The CRF1 receptor antagonist, antalarmin, reverses isolation‐induced up‐regulation of dopamine D2 receptors in the amygdala and nucleus accumbens of fawn‐hooded rats

Djouma, E., Card, K., Lodge, D. J., & Lawrence, A. J. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04864.x · Cited by 63 · see citing works

Effect of social isolation on the reinforcing properties of morphine in the conditioned place preference test

Wongwitdecha, N., & Marsden, C. A. (1996) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)02046-2 · Cited by 63 · see citing works

Long-term social isolation enhances picrotoxin seizure susceptibility in mice: up-regulatory role of endogenous brain allopregnanolone in GABAergic systems

Matsumoto, K., Nomura, H., Murakami, Y., Taki, K., Takahata, H., & Watanabe, H. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00169-2 · Cited by 63 · see citing works

Chronic administration of clozapine alleviates reversal-learning impairment in isolation-reared rats

Li, N., Wu, X. H., & Li, L. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3280d3ee83 · Cited by 61 · see citing works

Lower Incidence and Increased Male: Female Ratio in Schizophrenia

Nicole, L., LESAGE, A. D., & Lalonde, P. (1992) · The British Journal of Psychiatry · doi:10.1192/bjp.161.4.556 · Cited by 61 · see citing works

Effects of housing density on alcohol intake in the rat

Deatherage, G. (1972) · Physiology & Behavior · doi:10.1016/0031-9384(72)90264-8 · Cited by 58 · see citing works

Long-term isolation of Wistar rats alters brain monoamine turnover, blood corticosterone, and ACTH

Miachon, S., Rochet, T., Mathian, B., Barbagli, B., & Claustrat, B. (1993) · Brain Research Bulletin · doi:10.1016/0361-9230(93)90162-5 · Cited by 58 · see citing works

Abnormalities of presynaptic protein CDCrel‐1 in striatum of rats reared in social isolation: relevance to neural connectivity in schizophrenia

Barr, A. M., Young, C. E., Sawada, K., Trimble, W. S., Phillips, A. G., & Honer, W. G. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03457.x · Cited by 57 · see citing works

The 5-HT 1A receptor agonist MKC-242 reverses isolation rearing-induced deficits of prepulse inhibition in mice

Sakaue, M., Ago, Y., Baba, A., & Matsuda, T. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1515-x · Cited by 57 · see citing works

Isolation rearing decreases opiate receptor binding in rat brain

Schenk, S., Britt, M. D., & Atalay, J. (1982) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(82)90245-3 · Cited by 55 · see citing works

The effects of social isolation on the forced swim test in Fawn hooded and Wistar rats

Hall, F. S., Huang, S., Fong, G., & Pert, A. (1998) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(97)00155-6 · Cited by 55 · see citing works

Post-weaning handling attenuates isolation-rearing induced disruptions of prepulse inhibition in rats

Krebs-Thomson, K., Giracello, D. R., Solis, A., & Geyer, M. A. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00374-0 · Cited by 54 · see citing works

The effects of isolation-rearing on sucrose consumption in rats

HALL, F., HUMBY, T., WILKINSON, L., & ROBBINS, T. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(97)00116-9 · Cited by 54 · see citing works

Reversal of isolation-rearing-induced PPI deficits by an α7 nicotinic receptor agonist

Cilia, J., Cluderay, J. E., Robbins, M. J., Reavill, C., Southam, E., Kew, J. N. C., & Jones, D. N. C. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0069-5 · Cited by 53 · see citing works

Behavioural comparisons between individually- and group-housed male rats: Effects of novel environments and diurnal rhythm

Gentsch, C., Lichtsteiner, M., & Feer, H. (1982) · Behavioural Brain Research · doi:10.1016/0166-4328(82)90084-5 · Cited by 52 · see citing works

The role of social isolation and sex in determining effects of chlordiazepoxide and methylphenidate on exploratory behaviour

Hughes, R. N., & Syme, L. A. (1972) · Psychopharmacology · doi:10.1007/bf00429389 · Cited by 51 · see citing works

Iloperidone reduces sensorimotor gating deficits in pharmacological models, but not a developmental model, of disrupted prepulse inhibition in rats

Barr, A. M., Powell, S. B., Markou, A., & Geyer, M. A. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.04.004 · Cited by 49 · see citing works

Isolation rearing-induced deficits in prepulse inhibition and locomotor habituation are not potentiated by water deprivation

Powell, S. B., Swerdlow, N. R., Pitcher, L., & Geyer, M. A. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00817-x · Cited by 49 · see citing works

Environmentally induced differences in susceptibility of rats to CNS stimulants and CNS depressants: Evidence against a unitary explanation

Einon, D. F., & Sahakian, B. J. (1979) · Psychopharmacology · doi:10.1007/bf00432276 · Cited by 48 · see citing works

Isolation rearing prevents the reinforcing properties of amphetamine in a conditioned place preference paradigm

Wongwitdecha, N., & Marsden, C. A. (1995) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00212-4 · Cited by 46 · see citing works

Housing conditions fail to affect the intravenous self-administration of amphetamine

Schenk, S., Robinson, B., & Amit, Z. (1988) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(88)90311-5 · Cited by 46 · see citing works

Social isolation and social interaction alter regional brain opioid receptor binding in rats

Vanderschuren, L. J. M. J., Stein, E. A., Wiegant, V. M., & van Ree, J. M. (1995) · European Neuropsychopharmacology · doi:10.1016/0924-977x(95)00010-m · Cited by 46 · see citing works

The influence of sex and social isolation housing on pre- and postsynaptic 5-HT1A receptors

Schiller, L., Jähkel, M., & Oehler, J. (2006) · Brain Research · doi:10.1016/j.brainres.2006.05.051 · Cited by 46 · see citing works

Social isolation effects on the “behavioral despair” forced swimming test: Effect of age and duration of testing

Yates, G., Panksepp, J., Ikemoto, S., et al. (1991) · Physiology & Behavior · doi:10.1016/0031-9384(91)90055-s · Cited by 45 · see citing works

Effects of individual housing on circadian rhythms of adult rats

Greco, A. M., Gambardella, P., Sticchi, R., et al. (1989) · Physiology & Behavior · doi:10.1016/0031-9384(89)90141-8 · Cited by 45 · see citing works

Effects of postweaning social isolation and re-socialization on the expression of vasoactive intestinal peptide (VIP) and dendritic development in the medial prefrontal cortex of the rat

Pascual, R., Zamora-León, S. P., & Valero‐Cabré, A. (2006) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2006-1582 · Cited by 44 · see citing works

Serotonin fibre densities in subcortical areas: differential effects of isolated rearing and methamphetamine

Lehmann, K., Lesting, J., Polascheck, D., & Teuchert-Noodt, G. (2003) · Developmental Brain Research · doi:10.1016/s0165-3806(03)00130-5 · Cited by 42 · see citing works

Anxiety-Like and Exploratory Behaviors of Isolation-Reared Mice in the Staircase Test

Ago, Y., Takahashi, K., Nakamura, S., Hashimoto, H., Baba, A., & Matsuda, T. (2007) · Journal of Pharmacological Sciences · doi:10.1254/jphs.fp0070325 · Cited by 42 · see citing works

Exploration, distraction, and habituation in rats reared in isolation

File, S. E. (1978) · Developmental Psychobiology · doi:10.1002/dev.420110111 · Cited by 42 · see citing works

Long-term Isolation in Rats reduces Morphine Response

Katz, D. M., & Steinberg, H. (1970) · Nature · doi:10.1038/228469a0 · Cited by 41 · see citing works

Individually reared rats: Alteration in noradrenergic brain functions

Kraeuchi, K., Gentsch, C., & Feer, H. (1981) · Journal of Neural Transmission · doi:10.1007/bf01249133 · Cited by 41 · see citing works

Post-weaning social isolation of rats leads to a diminution of LTP in the CA1 to subiculum pathway

Roberts, L., & Greene, J. R. T. (2003) · Brain Research · doi:10.1016/j.brainres.2003.08.022 · Cited by 41 · see citing works

Routine post-weaning handling of rats prevents isolation rearing-induced deficit in prepulse inhibition

Rosa, M. L. N. M., Silva, R. C. B., Moura-de-Carvalho, F. T., Brandão, M. L., Guimarães, F. S., & Bel, E. A. D. (2005) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2005001100018 · Cited by 40 · see citing works

Eating behavior: Social facilitation or social inhibition?

Shelley, H. P. (1965) · Psychonomic Science · doi:10.3758/bf03343264 · Cited by 40 · see citing works

Effect of isolation-rearing on noradrenaline release in rat hypothalamus and hippocampus in vitro

Fulford, A. J., & Marsden, C. A. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01279-6 · Cited by 39 · see citing works

Social isolation in the rat enhances α2-autoreceptor function in the hippocampus in vivo

Fulford, A. J., & Marsden, C. A. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00499-x · Cited by 39 · see citing works

Enhanced corticosterone release after a modified forced swim test in Fawn hooded rats is independent of rearing experience

Hall, F. S., Sundstrom, J. M., Lerner, J., & Pert, A. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00556-1 · Cited by 38 · see citing works

Visual-spatial learning and memory in schizotypal personality disorder: Continued evidence for the importance of working memory in the schizophrenia spectrum☆

McClure, M. M., Romero, M. J., Bowie, C. R., Reichenberg, A., Harvey, P. D., & Siever, L. J. (2006) · Archives of Clinical Neuropsychology · doi:10.1016/j.acn.2006.11.004 · Cited by 38 · see citing works

Social interaction: responses to chlordiazepoxide and the loss of isolation-reared effects with paired-housing

Vale, A. L., & Montgomery, A. M. J. (1997) · Psychopharmacology · doi:10.1007/s002130050382 · Cited by 37 · see citing works

Psychoactive drug effect on behavioural changes induced by prolonged socio-environmental deprivation in rats

Valzelli, L., & Bernasconi, S. (1976) · Psychological Medicine · doi:10.1017/s0033291700013829 · Cited by 37 · see citing works

Isolation housing decreases the effectiveness of morphine in the conditioned taste aversion paradigm

Schenk, S., Hunt, T., Klukowski, G., et al. (1987) · Psychopharmacology · doi:10.1007/bf00215478 · Cited by 36 · see citing works

Structural and functional abnormalities of the hippocampal formation in rats with environmentally induced reductions in prepulse inhibition of acoustic startle

Greene, J. R. T., Kerkhoff, J. E., Guiver, L., & Totterdell, S. (2001) · Neuroscience · doi:10.1016/s0306-4522(00)00560-1 · Cited by 35 · see citing works

An intact dopaminergic system is required for context-conditioned release of 5-HT in the nucleus accumbens of postweaning isolation-reared rats

Fulford, A. J., & Marsden, C. A. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.08.002 · Cited by 35 · see citing works

Ontogenetic interaction between social relationships and defensive burying behavior in the rat

Arakawa, H. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.12.015 · Cited by 34 · see citing works

EARLY SOCIAL ISOLATION DECREASES THE EXPRESSION OF CALBINDIN D-28K AND DENDRITIC BRANCHING IN THE MEDIAL PREFRONTAL CORTEX OF THE RAT

Pascual, R., Zamora-León, S. P., Catalán-Ahumada, M., & Valero‐Cabré, A. (2007) · International Journal of Neuroscience · doi:10.1080/00207450600773459 · Cited by 34 · see citing works

Evidence for altered α2-adrenoceptor function following isolation-rearing in the rat

Fulford, A. J., Butler, S., Heal, D. J., et al. (1994) · Psychopharmacology · doi:10.1007/bf02245061 · Cited by 33 · see citing works

Blockage of histamine H1 receptor attenuates social isolation-induced disruption of prepulse inhibition: a study in H1 receptor gene knockout mice

Dai, H., Okuda, T., Sakurai, E., Kuramasu, A., Kato, M., Jia, F., Xu, A., Iinuma, K., Sato, I., & Yanai, K. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0203-4 · Cited by 33 · see citing works

Intellectual functioning and memory deficits in schizophrenia

Ruíz, J. C., Soler, M. J., Fuentes-Durá, I., et al. (2007) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2006.11.002 · Cited by 33 · see citing works

The effects of isolation rearing on glutamate receptor NMDAR1A mRNA expression determined by in situ hybridization in Fawn hooded and Wistar rats

Hall, F. S., Ghaed, S., Pert, A., & Xing, G. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00796-7 · Cited by 32 · see citing works

Reduced N-acetylaspartate in the temporal cortex of rats reared in isolation.

Harte, M., Powell, S., Reynolds, L. M., Swerdlow, N., Geyer, M., & Reynolds, G. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.06.009 · Cited by 31 · see citing works

Isolation rearing enhances acquisition in a conditioned inhibition paradigm.

Harmer, C., & Phillips, G. (1998) · Physiology and Behavior · doi:10.1016/s0031-9384(98)00207-8 · Cited by 28 · see citing works

The Effects of M100907 in Pharmacological and Developmental Animal Models of Prepulse Inhibition Deficits in Schizophrenia

Geyer, M. A. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00123-2 · Cited by 28 · see citing works

Effects of early social deprivation on emotionality in rats.

Koch, M. D., & Arnold, W. J. (1972) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0032380 · Cited by 27 · see citing works

Early life stress and development: potential mechanisms for adverse outcomes

Smith, K. E., & Pollak, S. D. (2020) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-020-09337-y · Cited by 500 · see citing works

Chronic stress-induced gut dysfunction exacerbates Parkinson's disease phenotype and pathology in a rotenone-induced mouse model of Parkinson's disease

Dodiya, H. B., Forsyth, C. B., Voigt, R. M., Engen, P. A., Patel, J., Shaikh, M., Green, S. J., Naqib, A., Roy, A., Kordower, J. H., et al. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.12.012 · Cited by 305 · see citing works

The role of the striatum in social behavior

Báez-Mendoza, R., & Schultz, W. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00233 · Cited by 312 · see citing works

Neural mechanisms of social homeostasis

Matthews, G. A., & Tye, K. M. (2019) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14016 · Cited by 273 · see citing works

Consequences of post-weaning social isolation on anxiety behavior and related neural circuits in rodents

Lukkes, J. L. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.018.2009 · Cited by 235 · see citing works

Impact of adolescent social experiences on behavior and neural circuits implicated in mental illnesses

Burke, A. R., McCormick, C. M., Pellis, S. M., & Lukkes, J. L. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.018 · Cited by 225 · see citing works

Involvement of NOX2 in the Development of Behavioral and Pathologic Alterations in Isolated Rats

Schiavone, S., Sorce, S., Dubois-Dauphin, M., Jaquet, V., Colaianna, M., Zotti, M., Cuomo, V., Trabace, L., & Krause, K.-H. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.04.033 · Cited by 208 · see citing works

Stress in adolescence and drugs of abuse in rodent models: role of dopamine, CRF, and HPA axis

Burke, A. R., & Miczek, K. A. (2014) · Psychopharmacology · doi:10.1007/s00213-013-3369-1 · Cited by 207 · see citing works

The effects of early life stress on reward processing

Novick, A. M., Levandowski, M. L., Laumann, L. E., Philip, N. S., Price, L. H., & Tyrka, A. R. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.02.002 · Cited by 192 · see citing works

What the Laboratory Rat has Taught us About Social Play Behavior: Role in Behavioral Development and Neural Mechanisms

Vanderschuren, L. J. M. J., & Trezza, V. (2013) · Current Topics in Behavioral Neurosciences · doi:10.1007/978-3-662-45758-0_268 · Cited by 200 · see citing works

Autonomic dysregulation and the Window of Tolerance model of the effects of complex emotional trauma

Corrigan, F., Fisher, J., & Nutt, D. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881109354930 · Cited by 195 · see citing works

Enhancement of endocannabinoid signaling with JZL184, an inhibitor of the 2-arachidonoylglycerol hydrolyzing enzyme monoacylglycerol lipase, produces anxiolytic effects under conditions of high environmental aversiveness in rats

Sciolino, N. R., Zhou, W., & Hohmann, A. G. (2011) · Pharmacological Research · doi:10.1016/j.phrs.2011.04.010 · Cited by 179 · see citing works

Social deprivation enhances VTA synaptic plasticity and drug-induced contextual learning

Whitaker, L. R., Degoulet, M., & Morikawa, H. (2013) · Neuron · doi:10.1016/j.neuron.2012.11.022 · Cited by 177 · see citing works

Behavioral and neurochemical consequences of cortical oxidative stress on parvalbumin-interneuron maturation in rodent models of schizophrenia

Powell, S. B., Sejnowski, T. J., & Behrens, M. M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.01.049 · Cited by 164 · see citing works

Selective blockade of dopamine D3 receptors enhances while D2 receptor antagonism impairs social novelty discrimination and novel object recognition in rats: a key role for the prefrontal cortex

Watson, D. J., Loiseau, F., Ingallinesi, M., Millan, M. J., Marsden, C. A., & Fone, K. C. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.254 · Cited by 151 · see citing works

Adolescent Onset of Cortical Disinhibition in Schizophrenia: Insights From Animal Models

O'Donnell, P. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr028 · Cited by 145 · see citing works

Critical age windows for neurodevelopmental psychiatric disorders: evidence from animal models

Marco, E. M., Macrì, S., & Laviola, G. (2011) · Neurotoxicity Research · doi:10.1007/s12640-010-9205-z · Cited by 144 · see citing works

Social Isolation Exacerbates Schizophrenia-Like Phenotypes via Oxidative Stress in Cortical Interneurons

Jiang, Z., Rompala, G. R., Zhang, S., Cowell, R. M., & Nakazawa, K. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.12.004 · Cited by 128 · see citing works

Post-weaning social isolation of rats leads to long-term disruption of the gut microbiota-immune-brain axis

Dunphy-Doherty, F., O'Mahony, S. M., Peterson, V. L., O'Sullivan, O., Crispie, F., Cotter, P. D., Wigmore, P., King, M. V., Cryan, J. F., & Fone, K. C. F. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.10.024 · Cited by 124 · see citing works

The Evidence for Altered BDNF Expression in the Brain of Rats Reared or Housed in Social Isolation: A Systematic Review

Murínová, J., Hlaváčová, N., Chmelová, M., & Riečanský, I. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00101 · Cited by 110 · see citing works

Post-weaning chronic social isolation produces profound behavioral dysregulation with decreases in prefrontal cortex synaptic-associated protein expression in female rats

Hermes, G., Li, N., Duman, C., & Duman, R. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.12.019 · Cited by 111 · see citing works

Neuroendocrine profile in a rat model of psychosocial stress: Relation to oxidative stress

Colaianna, M., Schiavone, S., Zotti, M., Tucci, P., Morgese, M. G., Bäckdahl, L., Holmdahl, R., Krause, K.-H., Cuomo, V., & Trabace, L. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4569 · Cited by 107 · see citing works

Progress in understanding mood disorders: optogenetic dissection of neural circuits

Lammel, S., Tye, K. M., & Warden, M. R. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12049 · Cited by 98 · see citing works

A Review of Biomarkers in Mood and Psychotic Disorders: A Dissection of Clinical vs. Preclinical Correlates

Brand, S., Moller, M., & Harvey, B. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666150307004545 · Cited by 95 · see citing works

Social isolation and chronic handling alter endocannabinoid signaling and behavioral reactivity to context in adult rats

Sciolino, N. R., Bortolato, M., Eisenstein, S. A., Fu, J., Oveisi, F., Hohmann, A. G., & Piomelli, D. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.04.007 · Cited by 89 · see citing works

Disrupted social development enhances the motivation for cocaine in rats

Baarendse, P. J. J., Limpens, J. H. W., & Vanderschuren, L. J. M. J. (2014) · Psychopharmacology · doi:10.1007/s00213-013-3362-8 · Cited by 87 · see citing works

Isolation rearing effects on probabilistic learning and cognitive flexibility in rats

Amitai, N., Young, J. W., Higa, K., Sharp, R. F., Geyer, M. A., & Powell, S. B. (2014) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-013-0204-4 · Cited by 74 · see citing works

Play fighting and the development of the social brain: The rat’s tale

Pellis, S. M., Pellis, V. C., Ham, J. R., & Stark, R. A. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105037 · Cited by 76 · see citing works

In search for boundary conditions of reconsolidation: a failure of fear memory interference

Schroyens, N., Beckers, T., & Kindt, M. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00065 · Cited by 70 · see citing works

Home alone: a systematic review and meta‐analysis on the effects of individual housing on body weight, food intake and visceral fat mass in rodents

Schipper, L., Harvey, L., van der Beek, E. M., & van Dijk, G. (2018) · Obesity Reviews · doi:10.1111/obr.12663 · Cited by 67 · see citing works

Social isolation induces deficit of latent learning performance in mice: a putative animal model of attention deficit/hyperactivity disorder

Ouchi, H., Ono, K., Murakami, Y., & Matsumoto, K. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.10.029 · Cited by 64 · see citing works

Constitutive genetic deletion of the growth regulator Nogo-A induces schizophrenia-related endophenotypes

Willi, R., Weinmann, O., Winter, C., Klein, J., Sohr, R., Schnell, L., Yee, B. K., Feldon, J., & Schwab, M. E. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4393-09.2010 · Cited by 52 · see citing works

Lithium attenuated the depressant and anxiogenic effect of juvenile social stress through mitigating the negative impact of interlukin-1β and nitric oxide on hypothalamic–pituitary–adrenal axis function

Haj-Mirzaian, A., Amiri, S., Kordjazy, N., Momeny, M., Razmi, A., Rahimi-Balaei, M., Amini-Khoei, H., Haj-Mirzaian, A., Marzban, H., Mehr, S. E., et al. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.12.024 · Cited by 46 · see citing works

Negative consequences of early-life adversity on substance use as mediated by corticotropin-releasing factor modulation of serotonin activity

Forster, G. L., Anderson, E. M., Scholl, J. L., Lukkes, J. L., & Watt, M. J. (2018) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.08.001 · Cited by 40 · see citing works

Neurobehavioural sequelae of social deprivation in rodents revisited: Modelling social adversity for developmental neuropsychiatric disorders

Robbins, T. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116664450 · Cited by 31 · see citing works

Male Long Evans rats reared with a Fischer-344 peer during the juvenile period show deficits in social competency: a role for play

Stark, R., & Pellis, S. M. (2020) · International Journal of Play · doi:10.1080/21594937.2020.1720142 · Cited by 32 · see citing works

The selective metabotropic glutamate 2/3 receptor agonist MGS0028 reverses isolation rearing-induced abnormal behaviors in mice

Ago, Y., Araki, R., Yano, K., Kawasaki, T., Chaki, S., Nakazato, A., Onoe, H., Hashimoto, H., Baba, A., Takuma, K., et al. (2012) · Journal of Pharmacological Sciences · doi:10.1254/jphs.11200sc · Cited by 29 · see citing works

Effects of increased opportunity for physical exercise and learning experiences on recognition memory and brain-derived neurotrophic factor levels in brain and serum of rats

Vedovelli, K., Silveira, E., Velho, E., Stertz, L., Kapczinski, F., Schröder, N., & Bromberg, E. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.08.012 · Cited by 26 · see citing works

The selective 5-HT 6 receptor antagonist SLV has putative cognitive- and social interaction enhancing properties in rodent models of cognitive impairment

de Bruin, N. M. W. J., van Loevezijn, A., Wicke, K. M., de Haan, M., Venhorst, J., Lange, J. H. M., de Groote, L., van der Neut, M. A. W., Prickaerts, J., Andriambeloson, E., et al. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.06.020 · Cited by 22 · see citing works

Interaction between trait and housing condition produces differential decision-making toward risk choice in a rat gambling task

Kim, W. Y., Cho, B. R., Kwak, M. J., & Kim, J.-H. (2017) · Scientific Reports · doi:10.1038/s41598-017-06408-4 · Cited by 19 · see citing works

Brief periods of positive peer interactions mitigate the effects of total social isolation in young<i>Octodon degus</i>

Colonnello, V., Iacobucci, P., Anderson, M. P., & Panksepp, J. (2011) · Developmental Psychobiology · doi:10.1002/dev.20520 · Cited by 13 · see citing works

Postweaning isolation affects responses to incentive contrast in adulthood

Cuenya, L., Mustaca, A., & Kamenetzky, G. (2015) · Developmental Psychobiology · doi:10.1002/dev.21273 · Cited by 9 · see citing works

Sex differences in prepulse inhibition of the acoustic startle response

Kumari, V., Gray, J. A., Gupta, P., Luscher, S., & Sharma, T. (2002) · Personality and Individual Differences · doi:10.1016/s0191-8869(02)00266-0 · Cited by 43 · see citing works

Divergent serotonergic system and stress: from neurochemical activity to behavior

Yoshioka, M., Matsumoto, M., & Togashi, H. (1999) · The Japanese Journal of Pharmacology · doi:10.1016/s0021-5198(19)34083-1

Treatment with Serotonergic Drugs of Emotional Disturbances in Patients with Dementia Disorders

Gottfries, C. (1994) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4615-8149-9_58 · Cited by 1 · see citing works

Neurochemical studies on central effects of mergocryptine. (II) Effect of mergocryptine on serotonergic systems in rat brain

Hashimoto, T., Katsura, M., & Kuriyama, K. (1990) · The Japanese Journal of Pharmacology · doi:10.1016/s0021-5198(19)55400-2 · Cited by 2 · see citing works

Neurochemical studies of stress-induced anorexia mediated by serotonergic mechanism in the hypothalamus

Shimizu, N. (1992) · Neuroscience Research Supplements · doi:10.1016/0921-8696(92)90685-t