The Kallikrein-Kinin System: Current and Future Pharmacological Targets

Effects of an Angiotensin-Converting–Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients

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The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints

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A Novel Angiotensin-Converting Enzyme–Related Carboxypeptidase (ACE2) Converts Angiotensin I to Angiotensin 1-9

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MEROPS: the peptidase database

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A Clinical Trial of the Angiotensin-Converting–Enzyme Inhibitor Trandolapril in Patients with Left Ventricular Dysfunction after Myocardial Infarction

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Effects of fermented milk peptides supplement on blood pressure and vascular function in spontaneously hypertensive rats

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Kallikrein-related peptidase 8 is expressed in myocardium and induces cardiac hypertrophy

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HOE-140, an antagonist of B2 receptor, protects against memory deficits and brain damage induced by moderate lateral fluid percussion injury in mice

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Nociceptors in Cardiovascular Functions: Complex Interplay as a Result of Cyclooxygenase Inhibition

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Kinin-kallikrein system: New perspectives in heart failure

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Analgesic Effects of 3-Substituted Derivatives of 1,4-Benzodiazepines and their Possible Mechanisms

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Characterisation of the normal canine serum proteome using a novel electrophoretic technique combined with mass spectrometry

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B2kinin receptors mediate the Indian red scorpion venom‐induced augmentation of visceral reflexes via the nitric oxide cyclic guanosine monophosphate pathway

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Differential regulation of collagen secretion by kinin receptors in cardiac fibroblast and myofibroblast

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Dipeptidyl-peptidase IV

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Cognitive Impairment in SLE: Mechanisms and Therapeutic Approaches

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Kinin B2 and B1 Receptors Activation Sensitize the TRPA1 Channel Contributing to Anastrozole-Induced Pain Symptoms

Fialho, M. F. P., Brum, E. D. S., Becker, G., Brusco, I., & Oliveira, S. M. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15041136 · Cited by 17

Interactome: Smart hematophagous triatomine salivary gland molecules counteract human hemostasis during meal acquisition

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Gene networking in colistin-induced nephrotoxicity reveals an adverse outcome pathway triggered by proteotoxic stress

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An overview of kinin mediated events in cancer progression and therapeutic applications

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Pharmacovigilance study of the association between dipeptidyl peptidase–4 inhibitors and angioedema using the FDA Adverse Event Reporting System (FAERS)

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Haplotype Association Mapping Identifies a Candidate Gene Region in Mice Infected WithStaphylococcus aureus

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Oversulfated Chondroitin Sulfate and OSCS-Contaminated Heparin Cause Dose- and Route-Dependent Hemodynamic Effects in the Rat

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Bradykinin signaling regulates solute permeability and cellular junction organization in lymphatic endothelial cells

Kempe, S., Fois, G., Brunner, C., Hoffmann, T. K., Hahn, J., & Greve, J. (2019) · Microcirculation · doi:10.1111/micc.12592 · Cited by 16

Tutorial review for peptide assays: An ounce of pre-analytics is worth a pound of cure

Maurer, J., Grouzmann, E., & Eugster, P. J. (2023) · Journal of Chromatography B · doi:10.1016/j.jchromb.2023.123904 · Cited by 15

Surface- and tip-enhanced Raman scattering of bradykinin onto the colloidal suspended Ag surface

Święch, D., Ozaki, Y., Kim, Y. C., & Proniewicz, L. M. (2015) · Physical Chemistry Chemical Physics · doi:10.1039/c5cp02319j · Cited by 15

Inhibitory role of kinins on microglial nitric oxide and tumor necrosis factor-α production

Ben-Shmuel, S., Gera, L., Danon, A., Ron, A., & Fleisher‐Berkovich, S. (2012) · Peptides · doi:10.1016/j.peptides.2012.03.026 · Cited by 15

‘There and Back Again’—Forward Genetics and Reverse Phenotyping in Pulmonary Arterial Hypertension

Swietlik, E. M., Prapa, M., Martin, J. M., Pandya, D., Auckland, K., Morrell, N. W., & Gräf, S. (2020) · Genes · doi:10.3390/genes11121408 · Cited by 15

A single nucleotide polymorphism in exon 3 of the kallikrein 1 gene is associated with large but not small abdominal aortic aneurysm

Biroš, E., Norman, P. E., Walker, P. J., Nataatmadja, M. I., West, M., & Golledge, J. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.04.017 · Cited by 15

Kinin B2 receptor deletion and blockage ameliorates cisplatin-induced acute renal injury

Estrela, G. R., Wasinski, F., Bacurau, R. F. P., Malheiros, D. M. A. C., Câmara, N. O. S., & Araújo, R. C. (2014) · International Immunopharmacology · doi:10.1016/j.intimp.2014.06.025 · Cited by 15

Peptidomic profiling of human cerebrospinal fluid identifies YPRPIHPA as a novel substrate for prolylcarboxypeptidase

Zhao, X., Southwick, K., Cardasis, H. L., Du, Y., Lassman, M. E., Xie, D., El-Sherbeini, M., Geissler, W. M., Pryor, K. D., Verras, A., et al. (2010) · PROTEOMICS · doi:10.1002/pmic.201000145 · Cited by 15

In Vivo Effects of Bradykinin B2 Receptor Agonists with Varying Susceptibility to Peptidases

Jean, M., Gera, L., Charest‐Morin, X., Marceau, F., & Bachelard, H. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00306 · Cited by 15

Clinical Features and Disease Course of Primary Angioedema Patients in a Tertiary Care Hospital

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Kinin B1 and B2 Receptors Contribute to Cisplatin-Induced Painful Peripheral Neuropathy in Male Mice

Becker, G., Fialho, M. F. P., Brusco, I., & Oliveira, S. M. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15030852 · Cited by 14

Influence of applied potential on bradykinin adsorption onto Ag, Au, and Cu electrodes

Proniewicz, L. M., Święch, D., Ignatjev, I., Niaura, G., Sobolewski, D., Prahl, A., & Proniewicz, L. M. (2013) · Journal of Raman Spectroscopy · doi:10.1002/jrs.4246 · Cited by 14

The role of kinins in the proliferation of fibroblast primed with TNF in scratch wound assay

França, A. J. V. B. D. V., Faveri, R. D., Nunes, R., Steimbach, V. M. B., Santin, J. R., & Quintão, N. L. M. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.09.036 · Cited by 14

Bradykinin B2 Receptor Signaling Increases Glucose Uptake and Oxidation: Evidence and Open Questions

Gregnani, M. F., Húngaro, T. G. R., Martins-Silva, L., Bäder, M., & Araújo, R. C. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01162 · Cited by 14

Alterations to the maternal circulating proteome after preeclampsia

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The relevance of kalikrein-kinin system via activation of B 2 receptor in LPS-induced fever in rats

Soares, D. D. M., Santos, D. R., Rummel, C. D., Ott, D., Melo, M. C. C., Roth, J., Calixto, J. Β., & de Souza, G. E. P. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.08.019 · Cited by 14

Diet-gene interaction: effects of polymorphisms in the ACE, AGT and BDKRB2 genes and the consumption of sodium, potassium, calcium, and magnesium on blood pressure of normotensive adult individuals

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Bradykinin Release Avoids High Molecular Weight Kininogen Endocytosis

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Angio-œdèmes iatrogènes: rôle des inhibiteurs de l'enzyme de conversion et des antagonistes des récepteurs à l'angiotensine II (sartans)

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The Kinin System: Present and Future Pharmacological Targets

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Contact System Activation in Patients with HAE and Normal C1 Inhibitor Function

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Cardiovascular expression of inflammatory signaling molecules, the kinin B1 receptor and COX2, in the rabbit: Effects of LPS, anti-inflammatory and anti-hypertensive drugs

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The relaxant effect of the Montivipera bornmuelleri snake venom on vascular contractility.

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Pathophysiology of Primary Hypertension

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Distribution and expression of B2-kinin receptor on human leukocyte subsets in young adults and elderly using flow cytometry

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The cardioprotective effect of dual metallopeptidase inhibition: respective roles of endogenous kinins and natriuretic peptides

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Markers of Restenosis after Percutaneous Transluminal Balloon Angioplasty in Patients with Critical Limb Ischemia

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Tissue Kallikrein supplementation in ischemic phase protects the neurovascular unit and attenuates reperfusion-induced injury in ischemic stroke

Ran, X., Xu, T., Ruan, H., Wang, X., & Zhang, Q. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107435 · Cited by 12

Wasp venom from Vespa magnifica acts as a neuroprotective agent to alleviate neuronal damage after stroke in rats

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Kinin B1 and B2 receptors mediate cancer pain associated with both the tumor and oncology therapy using aromatase inhibitors

Brusco, I., Becker, G., Palma, T. V., Pillat, M. M., Scussel, R., Steiner, B. T., Sampaio, T. B., Ardisson-Araújo, D. M. P., de Andrade, C. M., Oliveira, M. S., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-31535-6 · Cited by 12

Venom Bradykinin-Related Peptides (BRPs) and Its Multiple Biological Roles

Lameu, C., Neiva, M., & Hayashi, M. A. F. (2013) · InTech eBooks · doi:10.5772/52872 · Cited by 12

Relation of Plasma Tissue Kallikrein Levels to Presence and Severity of Coronary Artery Disease in a Chinese Population

Zhang, Q., Ran, X., & Wang, D. W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091780 · Cited by 12

“Reverse degradomics”, monitoring of proteolytic trimming by multi‐CE and confocal detection of fluorescent substrates and reaction products

Piccard, H., Hu, J., Fiten, P., Proost, P., Martens, E., den Steen, P. E. V., Damme, J. V., & Opdenakker, G. (2009) · Electrophoresis · doi:10.1002/elps.200800698 · Cited by 12

The kinin system in hypertensive pathophysiology

Sharma, J. N. (2012) · Inflammopharmacology · doi:10.1007/s10787-012-0137-5 · Cited by 12

ALTERATION OF SPLICING PATTERN ON ANGIOTENSIN CONVERTING ENZYME GENE DUE TO THE INSERTION OF ALU ELEMENTS

Purwaningroom, D. L., Saifurrohman, M., Widodo, N., Putri, J. F., & Lukitasari, M. (2015) · International Journal for Computational Biology · doi:10.34040/ijcb.4.2.2015.61 · Cited by 12

Renal cortical regulation of COX-1 and functionally related products in early renovascular hypertension (rat)

Theilig, F., Dêbiec, H., Nafz, B., Ronco, P. M., Nüsing, R. M., Seyberth, H. W., Pavenstädt, H. J., Bouby, N., & Bachmann, S. (2006) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00099.2006 · Cited by 12

Urodilatin reverses the detrimental influence of bradykinin in acute ischemic stroke

Dobrivojević, M., Špiranec, K., Gorup, D., Erjavec, I., Habek, N., Radmilović, M., Unfirer, S., Ćosić, A., Drenjančević, I., Gajović, S., et al. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.07.007 · Cited by 12

Activation of the Bradykinin System by Angiotensin-Converting Enzyme Inhibitors

Sharma, J. N. (2010) · European Journal of Inflammation · doi:10.1177/1721727x1000800201 · Cited by 12

Tip-enhanced Raman spectroscopy of bradykinin and its B 2 receptor antagonists adsorbed onto colloidal suspended Ag nanowires

Święch, D., Tanabe, I., Vantasin, S., Sobolewski, D., Ozaki, Y., Prahl, A., Maćkowski, S., & Proniewicz, L. M. (2015) · Physical Chemistry Chemical Physics · doi:10.1039/c5cp03438h · Cited by 11

Differential action of bradykinin on intrarenal regional perfusion in the rat: waning effect in the cortex and major impact in the medulla

Bądzyńska, B., & Sadowski, J. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.172007 · Cited by 11

The Role of Inflammatory Mediator Bradykinin in Cardiovascular and Renal Diseases

Jn, S. (2012) · Journal of Autacoids · doi:10.4172/scientificreports.142 · Cited by 11

Tissue Kallikrein Attenuates Choroidal Neovascularization via Cleavage of Vascular Endothelial Growth Factor

Fukuhara, J., Noda, K., Murata, M., Namba, S., Kinoshita, S., Dong, Z., Andõ, R., Lennikov, A., Kanda, A., & Ishida, S. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-10512 · Cited by 11

KLK6 mediates stemness and metabolism of gastric carcinoma cells via the PI3K/AKT/mTOR signaling pathway

Zhou, D., He, Y., Li, H., & Huang, W. (2021) · Oncology Letters · doi:10.3892/ol.2021.13085 · Cited by 11

Autoimmune Diabetes Is Suppressed by Treatment with Recombinant Human Tissue Kallikrein-1

Maneva-Radicheva, L., Amatya, C., Parker, C., Ellefson, J., Radichev, I., Raghavan, A., Charles, M. L., Williams, M. S., Robbins, M. S., & Savinov, A. Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107213 · Cited by 11

Farnesoid X receptor regulates vasoreactivity via Angiotensin II type 2 receptor and the kallikrein‐kinin system in vascular endothelial cells

Zhang, R., Ran, H., Peng, L., Zhang, Y., Shen, W., Sun, T., Cao, F., & Chen, Y. (2015) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12535 · Cited by 11

Unveiling the participation of avian kinin ornithokinin and its receptors in the chicken inflammatory response

Guabiraba, R., Garrido, D., Bailleul, G., Trotereau, A., Pinaud, M., Lalmanach, A.-C., Chanteloup, N., & Schouler, C. (2017) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2017.04.005 · Cited by 11

The Effects of Bradykinin B1 Receptor Antagonism on the Myocardial and Vascular Consequences of Hypertension in SHR Rats

Deres, L., Erős, K., Horváth, O., Bencze, N., Csekõ, C., Farkas, S., Habon, T., Tóth, K., & Halmosi, R. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00624 · Cited by 11

Proteases/Antiproteases in Inflammatory Bowel Diseases

Motta, J., Martin, L., & Vergnolle, N. (2011) · Springer eBooks · doi:10.1007/978-3-0348-0157-7_8 · Cited by 11

Association of the KLK1 rs5516 G allele and the ACE D allele with aortic aneurysm and atherosclerotic stenosis

Zhang, Y., Huang, H., Ma, Y., Sun, Y., Wang, G., & Tang, L. (2016) · Medicine · doi:10.1097/md.0000000000005120 · Cited by 10

Bradykinin promotes Toll like receptor-4 expression in human gingival fibroblasts

Gutiérrez‐Venegas, G., Arreguín-Cano, J. A., & Bermúdez, C. H. (2012) · International Immunopharmacology · doi:10.1016/j.intimp.2012.07.021 · Cited by 10

Plasma Kallikrein as a Modulator of Liver Injury/Remodeling

Ahmed, I. A., Jaffa, M. A., Moussa, M., Hatem, D., El‐Achkar, G. A., Sayegh, R. A., Karam, M., Hamade, E., Habib, A., & Jaffa, A. A. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.715111 · Cited by 10

Kallikrein-kinin in stem cell therapy

Chao, J. (2014) · World Journal of Stem Cells · doi:10.4252/wjsc.v6.i4.448 · Cited by 10

Chromenones as potent bradykinin B1 antagonists

Bryan, M. C., Biswas, K., Peterkin, T. A. N., Rzasa, R. M., Arik, L., Lehto, S. G., Sun, H. Q., Hsieh, F.-Y., Xu, C., Fremeau, R. T., et al. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.10.068 · Cited by 10

Interaction between bradykinin and natriuretic peptides via RGS protein activation in HEK-293 cells

Dobrivojević, M., Sinđić, A., Edemir, B., Kalweit, S., Forssmann, W., & Hirsch, J. R. (2012) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00033.2012 · Cited by 10

Bioactive Peptides Produced by Limited Proteolysis

de Camargo, A. C. M., Fernandes, B. L., Cruz, L., & Ferro, E. S. (2012) · Colloquium Series on Neuropeptides · doi:10.4199/c00056ed1v01y201204npe002 · Cited by 9

Examination of genetic variants involved in generation and biodisposition of kinins in patients with angioedema

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Bradykinin promotes murine melanoma cell migration and invasion through endogenous production of superoxide and nitric oxide

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