Pathology of small vessel stroke
Abstract
Disease of small intracerebral vessels is widely assumed to be responsible for the majority of small, deep-seated (lacunar) infarcts and primary intracerebral haemorrhages. Our present, limited understanding of the pathogenesis of these stroke subtypes, which together constitute up to one-third of all strokes, is based on a limited number of detailed pathology studies, supported by clinical, risk factor and imaging data. Further progress using these traditional approaches has been prevented by a variety of largely technical obstacles. It is suggested that advances in our understanding of the genetic basis of established and new animal stroke models, in turn linked to more focused human genetic stroke surveys, may hold the key to further insights.
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In humans, damage to microvessels is a known pathological condition.
“In humans, damage to microvessels is a known pathological condition [50–54].”
From Two-Photon Imaging of Cortical Surface Microvessels Reveals a Robust Redistribution in Blood Flow after Vascular Occlusion (2006) · cites this paper as [50]
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Lang, B., Kindy, M. S., Kozel, F. A., Schultz, S. K., & Taheri, S. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170733 · Cited by 11 · see citing works
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The Micron Stroke Hypothesis of Alzheimer’s Disease and Dementia
Orehek, A. J. (2012) · Medical Hypotheses · doi:10.1016/j.mehy.2012.01.020 · Cited by 10 · see citing works
Differing Risk Factors and Outcomes In Ischemic Stroke Subtypes: Focus on Lacunar Stroke
Wardlaw, J. M. (2011) · Future Neurology · doi:10.2217/fnl.11.1 · Cited by 9 · see citing works
Bork, C. S., Lundbye‐Christensen, S., Venø, S. K., Lasota, A. N., Tjønneland, A. M., Schmidt, E. B., & Overvad, K. (2023) · European Journal of Nutrition · doi:10.1007/s00394-022-03081-w · Cited by 7 · see citing works
Mechanisms underlying microbleeds
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What Caused This Transient or Persisting Ischaemic Event?
Warlow, C. P., van Gijn, J., Dennis, M. S., Wardlaw, J. M., Bamford, J., Hankey, G. J., Sandercock, P. A., Rinkel, G. J. E., Langhorne, P., Sudlow, C. L. M., et al. (2008) · Stroke · doi:10.1002/9780470696361.ch6 · Cited by 7 · see citing works
Pathophysiology and Mechanisms Whereby Hypertension May Cause Stroke
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Lacunar Stroke in a Teenager After Minor Head Trauma
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Neurological Disorders and Related Problems in the Elderly
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Which Arterial Territory is Involved?
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Long-term effects of the cholesterol level and its drug treatment
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Protein kinase Cη polymorphism and the susceptibility to ischemic stroke in the Taiwan population
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Laküner infarktlar ve laküner sendromlar
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Rasaholiarison, N. F., Randrianasolo, R. O., Rajaonarison, L. A., Rakotomanana, J. L., Razafimahefa, J., & Tehindrazanarivelo, A. D. (2017) · Pan African Medical Journal · doi:10.11604/pamj.2017.28.76.13593 · Cited by 2 · see citing works
- Authors
- Alistair Lammie, G.
- Venue
- British Medical Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-01-01
- Volume
- 56
- Issue
- 2
- Pages
- 296-306
- ISSN
- 0007-1420 (ISSN-L)
- 1471-8391
- OpenAlex
- W2096193226
- Cited by
- 133
- References
- 25
- Citations by year
- 2024: 3 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 11 · 2018: 4 · 2017: 5 · 2016: 5 · 2015: 7 · 2014: 8 · 2013: 10 · 2012: 12
- FWCI
- 0.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- British Medical Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Cerebrovascular and genetic disorders
- Health Sciences › Medicine › Neurology › Intracerebral and Subarachnoid Hemorrhage Research
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Keywords
- cerebral small vessel disease, lacunar infarction, intracerebral hemorrhage, stroke pathogenesis, animal models of stroke
- MeSH terms
- Cerebral Hemorrhage, Cerebral Infarction, Humans, Stroke
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