Hyperbaric oxygen: the Medical Research Council trials and their clinical significance
Abstract
The clinical trials of the use of hyperbaric oxygen in radiotherapy conducted by the Medical Research Council's working party have shown that local cure and survival can be improved in head and neck and cervical cancer. Evidence for benefit has been presented in carcinoma of bronchus, but none has so far been found in carcinoma of the bladder. Although hyperbaric oxygen has produced increased effect upon normal tissues as well as upon tumour, a real improvement in therapeutic ratio appears to be present. The future use of hyperbaric oxygen in radiotherapy will depend upon a comparison of effectiveness with other methods now being tested to improve radiotherapy. The trials have yielded much fundamental and clinical data of general relevance in the radiotherapy of malignant disease.
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In a phase III trial conducted before 1977, HBO was shown to act synergistically with radiotherapy to improve locoregional control of head and neck tumors.
“In a phase III trial conducted before 1977, HBO was shown to act synergistically with radiotherapy to improve locoregional control of head and neck tumors. 380”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [380]
Cites
American Journal of Roentgenology
Bell, D. A., Campos, A., & Deng, F. (2017) · Radiopaedia.org · doi:10.53347/rid-56407 · Cited by 808 · see citing works
Bell, D. A., Campos, A., & Banerjee, D. (2017) · Radiopaedia.org · doi:10.53347/rid-56851 · Cited by 391 · see citing works
RADIOTHERAPY AND HYPERBARIC OXYGEN IN HEAD AND NECK CANCER
Henk, J. M., & Smith, C. W. (1977) · The Lancet · doi:10.1016/s0140-6736(77)90117-9 · Cited by 320 · see citing works
RADIOTHERAPY AND HYPERBARIC OXYGEN IN HEAD AND NECK CANCER
Henk, J. M., Kunkler, P. B., & Smith, C. W. (1977) · The Lancet · doi:10.1016/s0140-6736(77)90116-7 · Cited by 229 · see citing works
Moench, H. C., & Phillips, T. L. (1972) · The American Journal of Surgery · doi:10.1016/0002-9610(72)90077-3 · Cited by 219 · see citing works
Distant Metastases in Squamous-Cell Carcinoma of the Uterine Cervix
Carlson, V., Delclos, L., & Fletcher, G. H. (1967) · Radiology · doi:10.1148/88.5.961 · Cited by 215 · see citing works
Hyperbaric oxygen and radiotherapy: a Medical Research Council trial in carcinoma of the bladder
Cade, I. S., McEwen, J. B., Dische, S., Saunders, M. I., Watson, E. R., Halnan, K. E., Wiernik, G., Perrins, D. J. D., & Sutherland, I. (1978) · British Journal of Radiology · doi:10.1259/0007-1285-51-611-876 · Cited by 182 · see citing works
Self-citationDOSE, TIME, VOLUME RELATIONSHIPS IN SQUAMOUS CELL CARCINOMA OF THE SUPRAGLOTTIC LARYNX
Shukovsky, L. J. (1970) · American Journal of Roentgenology · doi:10.2214/ajr.108.1.27 · Cited by 179 · see citing works
The Place of Oxygen in Radiotherapy
Churchill‐Davidson, I., Foster, C. A., Wiernik, G., Collins, C. D., Pizey, N. C. D., Skeggs, D., & Purser, P. R. (1966) · British Journal of Radiology · doi:10.1259/0007-1285-39-461-321 · Cited by 75 · see citing works
Medical and surgical adrenalectomy in patients with advanced breast carcinoma
Newsome, H. H., Brown, P. W. G., Terz, J. J., & Lawrence, W. (1977) · Cancer · doi:10.1002/1097-0142(197702)39:2 · Cited by 60 · see citing works
Fraction size in radiobiology and radiotherapy
菅原, 努., Révész, L., & Scott, O. C. A. (1973) · Medical Entomology and Zoology · Cited by 51 · see citing works
Tumour regression as a guide to prognosis: a study with experimental animals
Denekamp, J. (1977) · British Journal of Radiology · doi:10.1259/0007-1285-50-592-271 · Cited by 50 · see citing works
van den Brenk, H. A. S. (1968) · PubMed · Cited by 49 · see citing works
HYPERBARIC OXYGEN IN RADIATION THERAPY
van den Brenk, H. A. S. (1968) · American Journal of Roentgenology · doi:10.2214/ajr.102.1.8 · Cited by 48 · see citing works
Clinical trials of radiotherapy in hyperbaric oxygen at Portsmouth, 1964–1976
Cade, I. S., & McEwen, J. B. (1978) · Clinical Radiology · doi:10.1016/s0009-9260(78)80081-6 · Cited by 41 · see citing works
RADIOTHERAPY OF ADVANCED CARCINOMA OF THE OROPHARYNGEAL REGION UNDER HYPERBARIC OXYGENATION
Chang, C. H., Conley, J., & Herbert, C. (1973) · American Journal of Roentgenology · doi:10.2214/ajr.117.3.509 · Cited by 35 · see citing works
Cancer of the uterine cervix in Aberdeenshire. Aetiological aspects.
Aitken-Swan, J., & Baird, D. (1966) · British Journal of Cancer · doi:10.1038/bjc.1966.76 · Cited by 35 · see citing works
Hyperbaric oxygen in radiation therapy
Glassburn, J. R., Brady, L. W., & Plenk, H. P. (1977) · Cancer · doi:10.1002/1097-0142(197702)39:2+ · Cited by 32 · see citing works
National Cancer Institute Monograph 23
(1966) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/37.6.907-a · Cited by 31 · see citing works
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Pogozelski, W. K., & Tullius, T. D. (1998) · Chemical Reviews · doi:10.1021/cr960437i · Cited by 1,018 · see citing works
Modulation of the tumor vasculature and oxygenation to improve therapy
Siemann, D. W., & Horsman, M. R. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.06.006 · Cited by 169 · see citing works
Hypoxia signaling in cancer: Implications for therapeutic interventions
Zhuang, Y., Liu, K., He, Q., Gu, X., Jiang, C., & Wu, J. (2023) · MedComm · doi:10.1002/mco2.203 · Cited by 119 · see citing works
- Authors
- Dische, S.
- Affiliations
- Mount Vernon Hospital (GB)
- Corresponding author
- Dische, S.
- Venue
- The British Journal of Radiology
- Publisher
- Oxford University Press (OUP)
- Published
- 1978-11
- Volume
- 51
- Issue
- 611
- Pages
- 888-894
- ISSN
- 0007-1285 (ISSN-L)
- 1748-880X
- OpenAlex
- W2101317014
- Cited by
- 154
- References
- 20
- Citations by year
- 2023: 1 · 2021: 1 · 2020: 1 · 2018: 2 · 2017: 1 · 2015: 3 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 13.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- British Journal of Radiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Radiation Therapy and Dosimetry
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- hyperbaric oxygen therapy, radiotherapy, head and neck cancer, cervical cancer, lung cancer, bladder cancer, survival, therapeutic index, normal tissue effects
- MeSH terms
- Urinary Bladder Neoplasms, Bronchial Neoplasms, Uterine Cervical Neoplasms, Clinical Trials as Topic, Female, Head and Neck Neoplasms, Humans, Hyperbaric Oxygenation, Middle Aged, Neoplasm Metastasis, Neoplasms, Radiotherapy Dosage
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