The DOI matches its Crossref record; 139 of the 139 references it cites were found in a registry or an index.
The RNA modification landscape in human disease
Open accessAbstract
RNA modifications have been historically considered as fine-tuning chemo-structural features of infrastructural RNAs, such as rRNAs, tRNAs, and snoRNAs. This view has changed dramatically in recent years, to a large extent as a result of systematic efforts to map and quantify various RNA modifications in a transcriptome-wide manner, revealing that RNA modifications are reversible, dynamically regulated, far more widespread than originally thought, and involved in major biological processes, including cell differentiation, sex determination, and stress responses. Here we summarize the state of knowledge and provide a catalog of RNA modifications and their links to neurological disorders, cancers, and other diseases. With the advent of direct RNA-sequencing technologies, we expect that this catalog will help prioritize those RNA modifications for transcriptome-wide maps.
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Self-citationFunctions and mechanisms of epigenetic inheritance in animals
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Metadata
- Authors
- Jonkhout, N., Tran, J., Smith, M. A., Schonrock, N., Mattick, J. S., & Novoa, E. M.
- Venue
- RNA
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2017-08-30
- Volume
- 23
- Issue
- 12
- Pages
- 1754-1769
- ISSN
- 1355-8382 (ISSN-L)
- 1469-9001
- OpenAlex
- W2753767186
- Cited by
- 606
- References
- 139
- FWCI
- 12.13
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Jonkhout, N., Tran, J., Smith, M. A., Schonrock, N., Mattick, J. S., & Novoa, E. M. (2017). The RNA modification landscape in human disease. RNA. https://doi.org/10.1261/rna.063503.117
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