The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Identification of glucose-regulated miRNAs from pancreatic β cells reveals a role for miR-30d in insulin transcription
Open accessAbstract
MicroRNAs (miRNAs) are small noncoding ribonucleotides that bind mRNAs and function mainly as translational repressors in mammals. MicroRNAs have been implicated to play a role in many diseases, including diabetes. Several reports indicate an important function for miRNAs in insulin production as well as insulin secretion. We have recently carried out a screen in the pancreatic β-cell line MIN6 to identify miRNAs with altered abundance in response to changes in glucose concentrations. This screen resulted in identification of 61 glucose-regulated miRNAs from a total of 108 miRNAs detectable in MIN6 cells. Many of the identified miRNAs, including miR-124a, miR-107, and miR-30d were up-regulated in the presence of high glucose. Only a few of the miRNAs, including miR-296, miR-484, and miR-690 were significantly down-regulated by high glucose treatment. Interestingly, we found that overexpression of miR-30d, one of the miRNAs up-regulated by glucose, increased insulin gene expression, while inhibition of miR-30d abolished glucose-stimulated insulin gene transcription. Overexpression or inhibition of miR-30d did not have any effect on insulin secretion. These data suggest that the putative target genes of miR-30d may be negative regulators of insulin gene expression.
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Combinatorial microRNA target predictions
Krek, A., Grün, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., MacMenamin, P., da Piedade, I., Gunsalus, K. C., Stoffel, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1536 · Cited by 4,603
A pancreatic islet-specific microRNA regulates insulin secretion
Poy, M. N., Eliasson, L., Krutzfeldt, J., Kuwajima, S., Ma, X., MacDonald, P. E., Pfeffer, S., Tuschl, T., Rajewsky, N., Rorsman, P., et al. (2004) · Nature · doi:10.1038/nature03076 · Cited by 2,102
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MicroRNA Expression Is Required for Pancreatic Islet Cell Genesis in the Mouse
Lynn, F. C., Skewes-Cox, P., Kosaka, Y., McManus, M. T., Harfe, B. D., & German, M. S. (2007) · Diabetes · doi:10.2337/db07-0175 · Cited by 351
MicroRNA-124a Regulates Foxa2 Expression and Intracellular Signaling in Pancreatic β-Cell Lines*
Baroukh, N., Ravier, M. A., Loder, M. K., Hill, E. V., Bounacer, A., Scharfmann, R., Rutter, G. A., & Van Obberghen, E. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611841200 · Cited by 326
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MicroRNAs in Development and Disease
Sayed, D., & Abdellatif, M. (2011) · Physiological Reviews · doi:10.1152/physrev.00006.2010 · Cited by 1,078
Karolina, D. S., Armugam, A., Tavintharan, S., Wong, M. T. K., Lim, S. C., Sum, C. F., & Jeyaseelan, K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022839 · Cited by 434
MiRNA Expression Profile of Human Subcutaneous Adipose and during Adipocyte Differentiation
Ortega, F. J., Moreno-Navarrete, J. M., Pardo, G., Sabater, M., Hummel, M., Ferrer, A., Rodriguez-Hermosa, J. I., Ruiz, B., Ricart, W., Peral, B., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009022 · Cited by 405
Finnerty, J. R., Wang, W.-X., Hébert, S. S., Wilfred, B. R., Mao, G., & Nelson, P. T. (2010) · Journal of Molecular Biology · doi:10.1016/j.jmb.2010.07.051 · Cited by 371
MicroRNA-mediated regulation of glucose and lipid metabolism
Agbu, P., & Carthew, R. W. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00354-w · Cited by 363
Metadata
- Authors
- Tang, X., Muniappan, L., Tang, G., & Özcan, S.
- Venue
- RNA
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2008-12-18
- Volume
- 15
- Issue
- 2
- Pages
- 287-293
- ISSN
- 1355-8382 (ISSN-L)
- 1469-9001
- OpenAlex
- W2108963354
- Cited by
- 276
- References
- 6
- FWCI
- 16.81
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Tang, X., Muniappan, L., Tang, G., & Özcan, S. (2009). Identification of glucose-regulated miRNAs from pancreatic β cells reveals a role for miR-30d in insulin transcription. RNA. https://doi.org/10.1261/rna.1211209
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