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The miR-15/107 group of microRNA genes: evolutionary biology, cellular functions, and roles in human diseases

Finnerty, John R., Wang, Wang-Xia, Hébert, Sébastien S., Wilfred, Bernard R., Mao, Guogen, Nelson, Peter T.·2010·Journal of Molecular Biology
DOI 10.1016/j.jmb.2010.07.051PMC PMC2978331
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  • The miR-15/107 family comprises 10 paralogous microRNAs that share a 5′ AGCAGC sequence.

    “The miR-15/107 family comprises a group of 10 paralogous microRNAs (miRNAs), sharing a 5′ AGCAGC sequence.”

    From Expression of miR-15/107 Family MicroRNAs in Human Tissues and Cultured Rat Brain Cells (2014) · cites this paper as [7]

  • Members of the miR-15/107 family have overlapping mRNA targets.

    “These miRNAs have overlapping targets.”

    From Expression of miR-15/107 Family MicroRNAs in Human Tissues and Cultured Rat Brain Cells (2014) · cites this paper as [7]

  • Since miR-15/107 miRNAs have highly overlapping targets and multiple members are transcribed at constitutively high levels, any therapeutic or diagnostic method based on one family member must also take into account the biological activities of other family members.

    “In other words, since miR-15/107 miRNAs have highly overlapping targets [7,16,41], and multiple members of the gene family are transcribed at constitutively high levels, any therapeutic or diagnostic method based on one family member must also take into account the biological activities of other family members.”

    From Expression of miR-15/107 Family MicroRNAs in Human Tissues and Cultured Rat Brain Cells (2014) · cites this paper as [7]

  • Because miR-15/107 miRNAs co-exist alongside highly-expressed miRNAs with overlapping targets, it is necessary to take into account the expression and activities of paralogous miRNAs, rather than just focusing on individual miRNAs in isolation.

    “Since miR-15/107 miRNAs (like many other miRNAs that have co-evolved with paralogs) co-exist alongside highly-expressed miRNAs with overlapping targets [7,16], these data provide support to the idea that it is necessary to take into account the expression and activities of paralogous miRNAs, rather than just focusing on individual miRNAs in isolation.”

    From Expression of miR-15/107 Family MicroRNAs in Human Tissues and Cultured Rat Brain Cells (2014) · cites this paper as [7]

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Cited by

Sorted by citations

Authors
Finnerty, J. R., Wang, W.-X., Hébert, S. S., Wilfred, B. R., Mao, G., & Nelson, P. T.
Venue
Journal of Molecular Biology
Publisher
Elsevier BV
Published
2010-09
Volume
402
Issue
3
Pages
491-509
ISSN
0022-2836
DOI
10.1016/j.jmb.2010.07.051
PMC
PMC2978331
Cited by
321
References
13
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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