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Filtering of deep sequencing data reveals the existence of abundant Dicer-dependent small RNAs derived from tRNAs
Open accessAbstract
Deep sequencing technologies such as Illumina, SOLiD, and 454 platforms have become very powerful tools in discovering and quantifying small RNAs in diverse organisms. Sequencing small RNA fractions always identifies RNAs derived from abundant RNA species such as rRNAs, tRNAs, snRNA, and snoRNA, and they are widely considered to be random degradation products. We carried out bioinformatic analysis of deep sequenced HeLa RNA and after quality filtering, identified highly abundant small RNA fragments, derived from mature tRNAs that are likely produced by specific processing rather than from random degradation. Moreover, we showed that the processing of small RNAs derived from tRNA Gln is dependent on Dicer in vivo and that Dicer cleaves the tRNA in vitro.
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Cites
Endogenous siRNAs Derived from Transposons and mRNAs in Drosophila Somatic Cells
Ghildiyal, M., Seitz, H., Horwich, M. D., Li, C., Du, T., Lee, S., Xu, J., Kittler, E. L. W., Zapp, M. L., Weng, Z., et al. (2008) · Science · doi:10.1126/science.1157396 · Cited by 645
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The role of non-coding RNAs in oncology
Slack, F. J., & Chinnaiyan, A. M. (2019) · Cell · doi:10.1016/j.cell.2019.10.017 · Cited by 1,619
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Schaefer, M., Pollex, T., Hanna, K., Tuorto, F., Meusburger, M., Helm, M., & Lyko, F. (2010) · Genes & Development · doi:10.1101/gad.586710 · Cited by 746
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Kumar, P., Kuscu, C., & Dutta, A. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.05.004 · Cited by 511
Metadata
- Authors
- Cole, C., Sobala, A., Lu, C., Thatcher, S. R., Bowman, A., Brown, J. W. S., Green, P. J., Barton, G. J., & Hutvagner, G.
- Venue
- RNA
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2009-10-22
- Volume
- 15
- Issue
- 12
- Pages
- 2147-2160
- ISSN
- 1355-8382 (ISSN-L)
- 1469-9001
- OpenAlex
- W2164256634
- Cited by
- 645
- References
- 1
- FWCI
- 12.72
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cole, C., Sobala, A., Lu, C., Thatcher, S. R., Bowman, A., Brown, J. W. S., Green, P. J., Barton, G. J., & Hutvagner, G. (2009). Filtering of deep sequencing data reveals the existence of abundant Dicer-dependent small RNAs derived from tRNAs. RNA. https://doi.org/10.1261/rna.1738409
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