The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
CpG-island promoters drive transcription of human telomeres
Open accessAbstract
The longstanding dogma that telomeres, the heterochromatic extremities of linear eukaryotic chromosomes, are transcriptionally silent was overturned by the discovery that DNA-dependent RNA polymerase II (RNAPII) transcribes telomeric DNA into telomeric repeat-containing RNA (TERRA). Here, we show that CpG dinucleotide-rich DNA islands, shared among multiple human chromosome ends, promote transcription of TERRA molecules. TERRA promoters sustain cellular expression of reporter genes, are located immediately upstream of TERRA transcription start sites, and are bound by active RNAPII in vivo. Finally, the identified promoter CpG dinucleotides are methylated in vivo, and cytosine methylation negatively regulates TERRA abundance. The existence of subtelomeric promoters, driving TERRA transcription from independent chromosome ends, supports the idea that TERRA exerts fundamental functions in the context of telomere biology.
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Citations
Cites
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750
DNA methylation landscapes: Provocative insights from epigenomics
Suzuki, M. M., & Bird, A. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2341 · Cited by 3,039
Origin of human chromosome 2: an ancestral telomere-telomere fusion.
IJdo, J. W., Baldini, A., Ward, D. C., Reeders, S. T., & Wells, R. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.20.9051 · Cited by 382
Telomeres: The silence is broken
Azzalin, C. M., & Lingner, J. (2008) · Cell Cycle · doi:10.4161/cc.7.9.5836 · Cited by 123
Self-citation
Cited by
RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells
Arora, R., Lee, Y., Wischnewski, H., Brun, C. M., Schwarz, T., & Azzalin, C. M. (2014) · Nature Communications · doi:10.1038/ncomms6220 · Cited by 469
Self-citationAgeing and the telomere connection: An intimate relationship with inflammation
Zhang, J., Rane, G., Dai, X., Shanmugam, M. K., Arfuso, F., Samy, R. P., Lai, M. K. P., Kappei, D., Kumar, A. P., & Sethi, G. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2015.11.006 · Cited by 386
Telomeric RNA-DNA hybrids affect telomere-length dynamics and senescence
Balk, B., Maicher, A., Dees, M., Klermund, J., Luke-Glaser, S., Bender, K., & Luke, B. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2662 · Cited by 296
Functional characterization of the TERRA transcriptome at damaged telomeres
Porro, A., Feuerhahn, S., Delafontaine, J., Riethman, H., Rougemont, J., & Lingner, J. (2014) · Nature Communications · doi:10.1038/ncomms6379 · Cited by 271
Nuclear respiratory factor 1 and endurance exercise promote human telomere transcription
Diman, A., Boros, J., Poulain, F., Rodriguez, J., Purnelle, M., Episkopou, H., Bertrand, L., Francaux, M., Deldicque, L., & Decottignies, A. (2016) · Science Advances · doi:10.1126/sciadv.1600031 · Cited by 101
Metadata
- Authors
- Nergadze, S. G., Farnung, B. O., Wischnewski, H., Khoriauli, L., Vitelli, V., Chawla, R., Giulotto, E., & Azzalin, C. M.
- Venue
- RNA
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2009-10-22
- Volume
- 15
- Issue
- 12
- Pages
- 2186-2194
- ISSN
- 1355-8382 (ISSN-L)
- 1469-9001
- OpenAlex
- W2119415471
- Cited by
- 249
- References
- 4
- FWCI
- 6.30
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Nergadze, S. G., Farnung, B. O., Wischnewski, H., Khoriauli, L., Vitelli, V., Chawla, R., Giulotto, E., & Azzalin, C. M. (2009). CpG-island promoters drive transcription of human telomeres. RNA. https://doi.org/10.1261/rna.1748309
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