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Cited by 123Telomeres, Telomerase, and SenescenceChromosomal and Genetic VariationsGenomics and Chromatin Dynamics

Telomeres: The silence is broken

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Azzalin, Claus M., Lingner, Joachim·2008·Cell Cycle
DOI 10.4161/cc.7.9.5836
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Abstract

The ends of linear eukaryotic chromosomes, telomeres, distinguish natural chromosome ends from DNA double stranded breaks and thus promote genome stability. Telomeres comprise a repetitive DNA skeleton, which is wrapped in specific protein complexes. Recent data indicate that an additional building block of telomeres is RNA and that the longstanding idea that telomeres are silent genomic regions needs to be overturned. Mammalian telomeres are indeed transcribed into RNA molecules, which remain associated with telomeric chromatin, suggesting RNA-mediated mechanisms in organizing telomere architecture.

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  • Telomere transcription seems to be mediated from within the telomere region of CpG islands with promoter activity identified within subtelomeric regions; these promoters can initiate transcription of TERRAs containing UUAGGG repeats.

    “In fact, telomere transcription seems to be mediated from within the telomere region of CpG islands with promoter activity (identified within subtelomeric regions). These promoters have been found to be able to initiate transcription of TERRAs, containing UUAGGG repeats [191].”

    From Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy (2024) · cites this paper as [191]

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Authors
Azzalin, C. M., & Lingner, J.
Affiliations
ETH Zurich (CH)
ORCID
Venue
Cell Cycle
Publisher
Informa UK Limited
Published
2008-05
Volume
7
Issue
9
Pages
1161-1165
ISSN
  • 1538-4101 (ISSN-L)
  • 1551-4005
DOI
10.4161/cc.7.9.5836
OpenAlex
W1973960108
Cited by
123
References
0
Citations by year
2026: 4 · 2025: 8 · 2024: 7 · 2023: 6 · 2022: 4 · 2021: 6 · 2020: 8 · 2019: 3 · 2018: 4 · 2017: 7 · 2016: 3 · 2015: 9 · 2014: 7 · 2013: 9 · 2012: 8
FWCI
1.08
Type
journal article
Language
en
Open access
Locations
  • Cell Cycle (publishedVersion)
  • PubMed (publishedVersion)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Funders
  • National Science Foundation
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Topics
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords
telomeres, telomere transcription, telomeric chromatin, genome stability, chromosome ends, repetitive DNA
MeSH terms
Animals, Gene Expression Regulation, Heterochromatin, Humans, RNA, Telomere, Cellular Senescence, Telomerase, RNA Interference, Chromosomal Instability, Epigenesis, Genetic

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