The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Metabolite-binding RNA domains are present in the genes of eukaryotes
Open accessAbstract
Genetic control by metabolite-binding mRNAs is widespread in prokaryotes. These riboswitches are typically located in noncoding regions of mRNA, where they selectively bind their target compound and subsequently modulate gene expression. We have identified mRNA elements in fungi and in plants that match the consensus sequence and structure of thiamine pyrophosphate-binding domains of prokaryotes. In Arabidopsis , the consensus motif resides in the 3′-UTR of a thiamine biosynthetic gene, and the isolated RNA domain binds the corresponding coenzyme in vitro. These results suggest that metabolite-binding mRNAs are possibly involved in eukaryotic gene regulation and that some riboswitches might be representatives of an ancient form of genetic control.
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Cites
Thiamine derivatives bind messenger RNAs directly to regulate bacterial gene expression
Winkler, W., Nahvi, A., & Breaker, R. R. (2002) · Nature · doi:10.1038/nature01145 · Cited by 1,242
Self-citationThe antiquity of RNA-based evolution.
Joyce, G. F. (2002) · Nature · doi:10.1038/418214a · Cited by 1,070
Genetic Control by a Metabolite Binding mRNA
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Self-citationAn mRNA structure that controls gene expression by binding FMN
Winkler, W. C., Cohen-Chalamish, S., & Breaker, R. R. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212628899 · Cited by 696
Self-citationSensing Small Molecules by Nascent RNA
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Coenzymes as fossils of an earlier metabolic state
White, H. B. (1976) · Journal of Molecular Evolution · doi:10.1007/bf01732468 · Cited by 493
Modern metabolism as a palimpsest of the RNA world
Benner, S. A., Ellington, A. D., & Tauer, A. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.18.7054 · Cited by 478
Comparative Genomics of Thiamin Biosynthesis in Procaryotes
Rodionov, D. A., Vitreschak, A. G., Mironov, A. A., & Gelfand, M. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208965200 · Cited by 353
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Thiamin biosynthesis in prokaryotes
Begley, T. P., Downs, D. M., Ealick, S. E., McLafferty, F. W., Van Loon, A. P. G. M., Taylor, S., Campobasso, N., Chiu, H.-J., Kinsland, C., Reddick, J. J., et al. (1999) · Archives of Microbiology · doi:10.1007/s002030050713 · Cited by 292
Cited by
Targeting RNA structures with small molecules
Childs-Disney, J. L., Yang, X., Gibaut, Q. M. R., Tong, Y., Batey, R. T., & Disney, M. D. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00521-4 · Cited by 587
Prospects for riboswitch discovery and analysis
Breaker, R. R. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.08.024 · Cited by 464
Self-citationStructural basis for gene regulation by a thiamine pyrophosphate-sensing riboswitch
Serganov, A., Polonskaia, A., Phan, A. T., Breaker, R. R., & Patel, D. J. (2006) · Nature · doi:10.1038/nature04740 · Cited by 441
Self-citationAn mRNA structure in bacteria that controls gene expression by binding lysine
Sudarsan, N., Wickiser, J. K., Nakamura, S., Ebert, M. S., & Breaker, R. R. (2003) · Genes & Development · doi:10.1101/gad.1140003 · Cited by 357
Self-citationThe Structural and Biochemical Foundations of Thiamin Biosynthesis
Jurgenson, C. T., Begley, T. P., & Ealick, S. E. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.78.072407.102340 · Cited by 355
Metadata
- Authors
- SUDARSAN, N., BARRICK, J. E., & BREAKER, R. R.
- Venue
- RNA
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2003-06
- Volume
- 9
- Issue
- 6
- Pages
- 644-647
- ISSN
- 1355-8382 (ISSN-L)
- 1469-9001
- OpenAlex
- W2151957804
- Cited by
- 420
- References
- 17
- FWCI
- 10.19
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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