The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Diverse roles of hnRNP L in mammalian mRNA processing: A combined microarray and RNAi analysis
Open accessAbstract
Alternative mRNA splicing patterns are determined by the combinatorial control of regulator proteins and their target RNA sequences. We have recently characterized human hnRNP L as a global regulator of alternative splicing, binding to diverse C/A-rich elements. To systematically identify hnRNP L target genes on a genome-wide level, we have combined splice-sensitive microarray analysis and an RNAi-knockdown approach. As a result, we describe 11 target genes of hnRNP L that were validated by RT-PCR and that represent several new modes of hnRNP L-dependent splicing regulation, involving both activator and repressor functions: first, intron retention; second, inclusion or skipping of cassette-type exons; third, suppression of multiple exons; and fourth, alternative poly(A) site selection. In sum, this approach revealed a surprising diversity of splicing-regulatory processes as well as poly(A) site selection in which hnRNP L is involved.
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Cites
Initial sequencing and comparative analysis of the mouse genome
Mouse Genome Sequencing Consortium (2002) · Nature · doi:10.1038/nature01262 · Cited by 7,187
Nova regulates brain-specific splicing to shape the synapse
Ule, J., Ule, A., Spencer, J., Williams, A., Hu, J.-S., Cline, M., Wang, H., Clark, T., Fraser, C., Ruggiu, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1610 · Cited by 509
Pan, Q., Shai, O., Misquitta, C., Zhang, W., Saltzman, A. L., Mohammad, N., Babak, T., Siu, H., Hughes, T. R., Morris, Q. D., et al. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.12.004 · Cited by 323
Cited by
Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches
Chen, M., & Manley, J. L. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2777 · Cited by 1,284
Characterizing the RNA targets and position-dependent splicing regulation by TDP-43
Tollervey, J. R., Curk, T., Rogelj, B., Briese, M., Cereda, M., Kayikci, M., König, J., Hortobágyi, T., Nishimura, A. L., Župunski, V., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2778 · Cited by 1,165
Functional diversity of the hnRNPs: past, present and perspectives
Han, S. P., Tang, Y. H., & Smith, R. (2010) · Biochemical Journal · doi:10.1042/bj20100396 · Cited by 527
Nucleosomes are well positioned in exons and carry characteristic histone modifications
Andersson, R., Enroth, S., Rada-Iglesias, A., Wadelius, C., & Komorowski, J. (2009) · Genome Research · doi:10.1101/gr.092353.109 · Cited by 325
Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2
Zhang, C., Zhang, Z., Castle, J., Sun, S., Johnson, J., Krainer, A. R., & Zhang, M. Q. (2008) · Genes & Development · doi:10.1101/gad.1703108 · Cited by 300
Metadata
- Authors
- Hung, L.-H., Heiner, M., Hui, J., Schreiner, S., Benes, V., & Bindereif, A.
- Venue
- RNA
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2007-12-11
- Volume
- 14
- Issue
- 2
- Pages
- 284-296
- ISSN
- 1355-8382 (ISSN-L)
- 1469-9001
- OpenAlex
- W2110304444
- Cited by
- 162
- References
- 3
- FWCI
- 5.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hung, L.-H., Heiner, M., Hui, J., Schreiner, S., Benes, V., & Bindereif, A. (2008). Diverse roles of hnRNP L in mammalian mRNA processing: A combined microarray and RNAi analysis. RNA. https://doi.org/10.1261/rna.725208
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