CoChat
Sign Up
Cited by 102Genomics and Chromatin DynamicsChromatin Remodeling and CancerEpigenetics and DNA Methylation

H2A.Z: a molecular rheostat for transcriptional control

Open access
Subramanian, Vidya, Fields, Paul A., Boyer, Laurie A.·2015·F1000Prime Reports
DOI 10.12703/p7-01PMC PMC4311278
Open this paper in CoChat — free accountOpen PDF

Abstract

The replacement of nucleosomal H2A with the histone variant H2A.Z is critical for regulating DNA-mediated processes across eukaryotes and for early development of multicellular organisms. How this variant performs these seemingly diverse roles has remained largely enigmatic. Here, we discuss recent mechanistic insights that have begun to reveal how H2A.Z functions as a molecular rheostat for gene control. We focus on specific examples in metazoans as a model for understanding how H2A.Z integrates information from histone post-translational modifications, other histone variants, and transcription factors (TFs) to regulate proper induction of gene expression programs in response to cellular cues. Finally, we propose a general model of how H2A.Z incorporation regulates chromatin states in diverse processes.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.12703/p7-01

Cites

5 of 5 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • H2A.Z occupancy seems to correlate with pioneer TF binding to nucleosome-occupied regions and has been suggested to act as a scaffold for binding of pioneer TFs and chromatin remodelers.

    “The role of H2A.Z in closed chromatin is less clear, but H2A.Z occupancy seems to correlate with pioneer TF binding to nucleosome-occupied regions and has been suggested to act as a scaffold for binding of pioneer TFs and chromatin remodelers (72,73).”

    From SOX9 reprograms endothelial cells by altering the chromatin landscape (2022) · cites this paper as [73]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 78

  1. [1]Sarma K Reinberg D Histone variants meet their match Nature reviews. Molecular cell biology 2005 6 139 49 10.1038/nrm1567 15688000 · DOI
  2. [2]Weber CM Henikoff S Histone variants: dynamic punctuation in transcription Genes & development 2014 28 672 82 10.1101/gad.238873.114 24696452 PMC4015494 · DOI
  3. [3]Skene PJ Henikoff S Histone variants in pluripotency and disease Development (Cambridge, England) 2013 140 2513 24 10.1242/dev.091439 23715545 · DOI
  4. [4]Maze I Noh K Soshnev AA Allis CD Every amino acid matters: essential contributions of histone variants to mammalian development and disease Nature reviews Genetics 2014 15 259 71 10.1038/nrg3673 24614311 PMC4082118 · DOI
  5. [5]Bönisch C Hake SB Histone H2A variants in nucleosomes and chromatin: more or less stable? Nucleic acids research 2012 40 10719 41 10.1093/nar/gks865 23002134 PMC3510494 · DOI
  6. [6]Creyghton MP Markoulaki S Levine SS Hanna J Lodato MA Sha K Young RA Jaenisch R Boyer LA H2AZ is enriched at polycomb complex target genes in ES cells and is necessary for lineage commitment Cell 2008 135 649 61 10.1016/j.cell.2008.09.056 18992931 PMC2853257 http://f1000.com/prime/1147365 · DOI
  7. [7]Subramanian V Mazumder A Surface LE Butty VL Fields PA Alwan A Torrey L Thai KK Levine SS Bathe M Boyer LA H2A.Z acidic patch couples chromatin dynamics to regulation of gene expression programs during ESC differentiation PLoS genetics 2013 9 e1003725 10.1371/journal.pgen.1003725 23990805 PMC3749939 · DOI
  8. [8]Hu G Cui K Northrup D Liu C Wang C Tang Q Ge K Levens D Crane-Robinson C Zhao K H2A.Z facilitates access of active and repressive complexes to chromatin in embryonic stem cell self-renewal and differentiation Cell stem cell 2013 12 180 92 10.1016/j.stem.2012.11.003 23260488 PMC3570599 · DOI
  9. [9]Sutcliffe EL Parish IA He YQ Juelich T Tierney ML Rangasamy D Milburn PJ Parish CR Tremethick DJ Rao S Dynamic histone variant exchange accompanies gene induction in T cells Molecular and cellular biology 2009 29 1972 86 10.1128/MCB.01590-08 19158270 PMC2655607 · DOI
  10. [10]Schones DE Cui K Cuddapah S Roh T Barski A Wang Z Wei G Zhao K Dynamic regulation of nucleosome positioning in the human genome Cell 2008 132 887 98 10.1016/j.cell.2008.02.022 18329373 PMC10894452 http://f1000.com/prime/1107027 · DOI
  11. [11]Dryhurst D McMullen B Fazli L Rennie PS Ausió J Histone H2A.Z prepares the prostate specific antigen (PSA) gene for androgen receptor-mediated transcription and is upregulated in a model of prostate cancer progression Cancer letters 2012 315 38 47 10.1016/j.canlet.2011.10.003 22055461 · DOI
  12. [12]Cuadrado A Corrado N Perdiguero E Lafarga V Muñoz-Canoves P Nebreda AR Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation The EMBO journal 2010 29 2014 25 10.1038/emboj.2010.85 20473270 PMC2892367 · DOI
  13. [13]Zlatanova J Thakar A H2A.Z: view from the top Structure (London, England:1993) 2008 16 166 79 18275809
  14. [14]Ku M Jaffe JD Koche RP Rheinbay E Endoh M Koseki H Carr SA Bernstein BE H2A.Z landscapes and dual modifications in pluripotent and multipotent stem cells underlie complex genome regulatory functions Genome biology 2012 13 R85 10.1186/gb-2012-13-10-r85 23034477 PMC3491413 · DOI
  15. [15]Guillemette B Bataille AR Gévry N Adam M Blanchette M Robert F Gaudreau L Variant histone H2A.Z is globally localized to the promoters of inactive yeast genes and regulates nucleosome positioning PLoS biology 2005 3 e384 10.1371/journal.pbio.0030384 16248679 PMC1275524 · DOI
  16. [16]Weber CM Henikoff JG Henikoff S H2A.Z nucleosomes enriched over active genes are homotypic Nature structural & molecular biology 2010 17 1500 7 10.1038/nsmb.1926 21057526 PMC3051840 · DOI
  17. [17]Rhee HS Pugh BF Genome-wide structure and organization of eukaryotic pre-initiation complexes Nature 2012 483 295 301 10.1038/nature10799 22258509 PMC3306527 http://f1000.com/prime/13491999 · DOI · Paper page
  18. [18]Nock A Ascano JM Barrero MJ Malik S Mediator-regulated transcription through the +1 nucleosome Molecular cell 2012 48 837 48 10.1016/j.molcel.2012.10.009 23159738 PMC3534924 · DOI
  19. [19]Weber CM Ramachandran S Henikoff S Nucleosomes are context-specific, H2A.Z-modulated barriers to RNA polymerase Molecular cell 2014 53 819 30 10.1016/j.molcel.2014.02.014 24606920 http://f1000.com/prime/718304563 · DOI
  20. [20]Leach TJ Mazzeo M Chotkowski HL Madigan JP Wotring MG Glaser RL Histone H2A.Z is widely but nonrandomly distributed in chromosomes of Drosophila melanogaster The Journal of biological chemistry 2000 275 23267 72 10.1074/jbc.M910206199 10801889 · DOI
  21. [21]Madigan JP Chotkowski HL Glaser RL DNA double-strand break-induced phosphorylation of Drosophila histone variant H2Av helps prevent radiation-induced apoptosis Nucleic acids research 2002 30 3698 705 10.1093/nar/gkf496 12202754 PMC137418 · DOI
  22. [22]Min IM Waterfall JJ Core LJ Munroe RJ Schimenti J Lis JT Regulating RNA polymerase pausing and transcription elongation in embryonic stem cells Genes & development 2011 25 742 54 10.1101/gad.2005511 21460038 PMC3070936 http://f1000.com/prime/9653956 · DOI
  23. [23]Sevilla A Binda O Post-translational modifications of the histone variant H2AZ Stem cell research 2014 12 289 95 10.1016/j.scr.2013.11.004 24316985 PMC4671304 · DOI
  24. [24]Yun M Wu J Workman JL Li B Readers of histone modifications Cell research 2011 21 564 78 10.1038/cr.2011.42 21423274 PMC3131977 · DOI
  25. [25]Bruce K Myers FA Mantouvalou E Lefevre P Greaves I Bonifer C Tremethick DJ Thorne AW Crane-Robinson C The replacement histone H2A.Z in a hyperacetylated form is a feature of active genes in the chicken Nucleic acids research 2005 33 5633 9 10.1093/nar/gki874 16204459 PMC1243646 · DOI
  26. [26]Valdés-Mora F Song JZ Statham AL Strbenac D Robinson MD Nair SS Patterson KI Tremethick DJ Stirzaker C Clark SJ Acetylation of H2A.Z is a key epigenetic modification associated with gene deregulation and epigenetic remodeling in cancer Genome research 2012 22 307 21 10.1101/gr.118919.110 21788347 PMC3266038 http://f1000.com/prime/717957008 · DOI
  27. [27]Keogh M Mennella TA Sawa C Berthelet S Krogan NJ Wolek A Podolny V Carpenter LR Greenblatt JF Baetz K Buratowski S The Saccharomyces cerevisiae histone H2A variant Htz1 is acetylated by NuA4 Genes & development 2006 20 660 5 10.1101/gad.1388106 16543219 PMC1413285 · DOI
  28. [28]Mehta M Braberg H Wang S Lozsa A Shales M Solache A Krogan NJ Keogh M Individual lysine acetylations on the N terminus of Saccharomyces cerevisiae H2A.Z are highly but not differentially regulated The Journal of biological chemistry 2010 285 39855 65 10.1074/jbc.M110.185967 20952395 PMC3000967 · DOI
  29. [29]Draker R Ng MK Sarcinella E Ignatchenko V Kislinger T Cheung P A combination of H2A.Z and H4 acetylation recruits Brd2 to chromatin during transcriptional activation PLoS genetics 2012 8 e1003047 10.1371/journal.pgen.1003047 23144632 PMC3493454 http://f1000.com/prime/720224432 · DOI
  30. [30]Shia W Pattenden SG Workman JL Histone H4 lysine 16 acetylation breaks the genome's silence Genome biology 2006 7 217 10.1186/gb-2006-7-5-217 16689998 PMC1779524 · DOI
  31. [31]Denis GV Bromodomain coactivators in cancer, obesity, type 2 diabetes, and inflammation Discovery medicine 2010 10 489 99 21189220 PMC3025494
  32. [32]Liu S Walker SR Nelson EA Cerulli R Xiang M Toniolo PA Qi J Stone RM Wadleigh M Bradner JE Frank DA Targeting STAT5 in hematologic malignancies through inhibition of the bromodomain and extra-terminal (BET) bromodomain protein BRD2 Molecular cancer therapeutics 2014 13 1194 205 10.1158/1535-7163.MCT-13-0341 24435449 PMC4013223 · DOI
  33. [33]LeRoy G Rickards B Flint SJ The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription Molecular cell 2008 30 51 60 10.1016/j.molcel.2008.01.018 18406326 PMC2387119 http://f1000.com/prime/1103930 · DOI
  34. [34]Belkina AC Denis GV BET domain co-regulators in obesity, inflammation and cancer Nature reviews. Cancer 2012 12 465 77 10.1038/nrc3256 22722403 PMC3934568 · DOI
  35. [36]Whyte WA Orlando DA Hnisz D Abraham BJ Lin CY Kagey MH Rahl PB Lee TI Young RA Master transcription factors and mediator establish super-enhancers at key cell identity genes Cell 2013 153 307 19 10.1016/j.cell.2013.03.035 23582322 PMC3653129 http://f1000.com/prime/718000122 · DOI · Paper page
  36. [37]Sarcinella E Zuzarte PC Lau Priscilla NI Draker R Cheung P Monoubiquitylation of H2A.Z distinguishes its association with euchromatin or facultative heterochromatin Molecular and cellular biology 2007 27 6457 68 10.1128/MCB.00241-07 17636032 PMC2099601 http://f1000.com/prime/1089782 · DOI
  37. [38]Draker R Sarcinella E Cheung P USP10 deubiquitylates the histone variant H2A.Z and both are required for androgen receptor-mediated gene activation Nucleic acids research 2011 39 3529 42 10.1093/nar/gkq1352 21245042 PMC3089478 http://f1000.com/prime/719377177 · DOI
  38. [39]Stock JK Giadrossi S Casanova M Brookes E Vidal M Koseki H Brockdorff N Fisher AG Pombo A Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells Nature cell biology 2007 9 1428 35 10.1038/ncb1663 18037880 http://f1000.com/prime/1098169 · DOI · Paper page
  39. [40]Blackledge NP Farcas AM Kondo T King HW McGouran JF Hanssen Lars LP Ito S Cooper S Kondo K Koseki Y Ishikura T Long HK Sheahan TW Brockdorff N Kessler BM Koseki H Klose RJ Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation Cell 2014 157 1445 59 24856970 PMC4048464 http://f1000.com/prime/718415419
  40. [41]Cooper S Dienstbier M Hassan R Schermelleh L Sharif J Blackledge NP Marco V de Elderkin S Koseki H Klose R Heger A Brockdorff N Targeting polycomb to pericentric heterochromatin in embryonic stem cells reveals a role for H2AK119u1 in PRC2 recruitment Cell reports 2014 7 1456 70 24857660 PMC4062935 http://f1000.com/prime/718415386
  41. [42]Kalb R Latwiel S Baymaz HI Jansen Pascal WTC Müller CW Vermeulen M Müller J Histone H2A monoubiquitination promotes histone H3 methylation in Polycomb repression Nature structural & molecular biology 2014 21 569 71 10.1038/nsmb.2833 24837194 http://f1000.com/prime/718397247 · DOI
  42. [43]Patel MC Debrosse M Smith M Dey A Huynh W Sarai N Heightman TD Tamura T Ozato K BRD4 coordinates recruitment of pause release factor P-TEFb and the pausing complex NELF/DSIF to regulate transcription elongation of interferon-stimulated genes Molecular and cellular biology 2013 33 2497 507 10.1128/MCB.01180-12 23589332 PMC3700095 http://f1000.com/prime/718000706 · DOI
  43. [45]Ruhl DD Jin J Cai Y Swanson S Florens L Washburn MP Conaway RC Conaway JW Chrivia JC Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes Biochemistry 2006 45 5671 7 10.1021/bi060043d 16634648 · DOI
  44. [46]Choi J Heo K An W Cooperative action of TIP48 and TIP49 in H2A.Z exchange catalyzed by acetylation of nucleosomal H2A Nucleic acids research 2009 37 5993 6007 10.1093/nar/gkp660 19696079 PMC2764430 · DOI
  45. [47]Papamichos-Chronakis M Watanabe S Rando OJ Peterson CL Global regulation of H2A.Z localization by the INO80 chromatin-remodeling enzyme is essential for genome integrity Cell 2011 144 200 13 10.1016/j.cell.2010.12.021 21241891 PMC3035940 http://f1000.com/prime/10351956 · DOI
  46. [48]Watanabe S Radman-Livaja M Rando OJ Peterson CL A histone acetylation switch regulates H2A.Z deposition by the SWR-C remodeling enzyme Science (New York, N.Y.) 2013 340 195 9 10.1126/science.1229758 23580526 PMC3727404 http://f1000.com/prime/717999660 · DOI
  47. [49]Burgess RJ Zhang Z Histone chaperones in nucleosome assembly and human disease Nature structural & molecular biology 2013 20 14 22 10.1038/nsmb.2461 23288364 PMC4004355 · DOI
  48. [50]Obri A Ouararhni K Papin C Diebold M Padmanabhan K Marek M Stoll I Roy L Reilly PT Mak TW Dimitrov S Romier C Hamiche A ANP32E is a histone chaperone that removes H2A.Z from chromatin Nature 2014 505 648 53 10.1038/nature12922 24463511 http://f1000.com/prime/718252262 · DOI
  49. [51]Mao Z Pan L Wang W Sun J Shan S Dong Q Liang X Dai L Ding X Chen S Zhang Z Zhu B Zhou Z Anp32e, a higher eukaryotic histone chaperone directs preferential recognition for H2A.Z Cell research 2014 24 389 99 10.1038/cr.2014.30 24613878 PMC3975505 http://f1000.com/prime/718310243 · DOI
  50. [52]Yen K Vinayachandran V Pugh BF SWR-C and INO80 chromatin remodelers recognize nucleosome-free regions near +1 nucleosomes Cell 2013 154 1246 56 10.1016/j.cell.2013.08.043 24034248 PMC4090706 http://f1000.com/prime/718110119 · DOI
  51. [53]Hong J Feng H Wang F Ranjan A Chen J Jiang J Ghirlando R Xiao TS Wu C Bai Y The catalytic subunit of the SWR1 remodeler is a histone chaperone for the H2A.Z-H2B dimer Molecular cell 2014 53 498 505 10.1016/j.molcel.2014.01.010 24507717 PMC3940207 http://f1000.com/prime/718270679 · DOI
  52. [54]Xie W Song C Young NL Sperling AS Xu F Sridharan R Conway AE Garcia BA Plath K Clark AT Grunstein M Histone h3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells Molecular cell 2009 33 417 27 10.1016/j.molcel.2009.02.004 19250903 PMC2671231 http://f1000.com/prime/722242022 · DOI · Paper page
  53. [55]Zilberman D Coleman-Derr D Ballinger T Henikoff S Histone H2A.Z and DNA methylation are mutually antagonistic chromatin marks Nature 2008 456 125 9 10.1038/nature07324 18815594 PMC2877514 http://f1000.com/prime/1123983 · DOI · Paper page
  54. [56]Conerly ML Teves SS Diolaiti D Ulrich M Eisenman RN Henikoff S Changes in H2A.Z occupancy and DNA methylation during B-cell lymphomagenesis Genome research 2010 20 1383 90 10.1101/gr.106542.110 20709945 PMC2945187 · DOI
  55. [57]Yang X Noushmehr H Han H Andreu-Vieyra C Liang G Jones PA Gene reactivation by 5-aza-2’-deoxycytidine-induced demethylation requires SRCAP-mediated H2A.Z insertion to establish nucleosome depleted regions PLoS genetics 2012 8 e1002604 10.1371/journal.pgen.1002604 22479200 PMC3315468 http://f1000.com/prime/720224769 · DOI
  56. [58]Hardy S Robert F Random deposition of histone variants: A cellular mistake or a novel regulatory mechanism? Epigenetics: official journal of the DNA Methylation Society 2010 5 368 72 20448466 http://f1000.com/prime/720580194
  57. [59]Hardy S Jacques P Gévry N Forest A Fortin M Laflamme L Gaudreau L Robert F The euchromatic and heterochromatic landscapes are shaped by antagonizing effects of transcription on H2A.Z deposition PLoS genetics 2009 5 e1000687 10.1371/journal.pgen.1000687 19834540 PMC2754525 http://f1000.com/prime/1165439 · DOI
  58. [60]Suto RK Clarkson MJ Tremethick DJ Luger K Crystal structure of a nucleosome core particle containing the variant histone H2A.Z Nature structural biology 2000 7 1121 4 10.1038/81971 11101893 · DOI
  59. [61]Luk E Ranjan A Fitzgerald PC Mizuguchi G Huang Y Wei D Wu C Stepwise histone replacement by SWR1 requires dual activation with histone H2A.Z and canonical nucleosome Cell 2010 143 725 36 10.1016/j.cell.2010.10.019 21111233 PMC7251641 http://f1000.com/prime/7830956 · DOI
  60. [62]Park Y Dyer PN Tremethick DJ Luger K A new fluorescence resonance energy transfer approach demonstrates that the histone variant H2AZ stabilizes the histone octamer within the nucleosome The Journal of biological chemistry 2004 279 24274 82 10.1074/jbc.M313152200 15020582 · DOI
  61. [63]Thakar A Gupta P McAllister WT Zlatanova J Histone variant H2A.Z inhibits transcription in reconstituted nucleosomes Biochemistry 2010 49 4018 26 10.1021/bi1001618 20387858 · DOI
  62. [64]Nekrasov M Amrichova J Parker BJ Soboleva TA Jack C Williams R Huttley GA Tremethick DJ Histone H2A.Z inheritance during the cell cycle and its impact on promoter organization and dynamics Nature structural & molecular biology 2012 19 1076 83 10.1038/nsmb.2424 23085713 http://f1000.com/prime/722615061 · DOI
  63. [65]Jin C Felsenfeld G Nucleosome stability mediated by histone variants H3.3 and H2A.Z Genes & development 2007 21 1519 29 10.1101/gad.1547707 17575053 PMC1891429 http://f1000.com/prime/1088008 · DOI
  64. [66]Jin C Zang C Wei G Cui K Peng W Zhao K Felsenfeld G H3.3/H2A.Z double variant-containing nucleosomes mark ‘nucleosome-free regions’ of active promoters and other regulatory regions Nature genetics 2009 41 941 5 10.1038/ng.409 19633671 PMC3125718 · DOI
  65. [67]Shu H Nakamura M Siretskiy A Borghi L Moraes I Wildhaber T Gruissem W Hennig L Arabidopsis replacement histone variant H3.3 occupies promoters of regulated genes Genome biology 2014 15 R62 10.1186/gb-2014-15-4-r62 24708891 PMC4054674 · DOI
  66. [68]Ahmad K Henikoff S The histone variant H3.3 marks active chromatin by replication-independent nucleosome assembly Molecular cell 2002 9 1191 200 10.1016/S1097-2765(02)00542-7 12086617 http://f1000.com/prime/1007380 · DOI
  67. [69]Zhang H Roberts DN Cairns BR Genome-wide dynamics of Htz1, a histone H2A variant that poises repressed/basal promoters for activation through histone loss Cell 2005 123 219 31 10.1016/j.cell.2005.08.036 16239141 PMC2788555 http://f1000.com/prime/1029195 · DOI
  68. [70]Fan JY Gordon F Luger K Hansen JC Tremethick DJ The essential histone variant H2A.Z regulates the equilibrium between different chromatin conformational states Nature structural biology 2002 9 172 6 10.1038/nsb0402-316b 11850638 http://f1000.com/prime/1004759 · DOI
  69. [71]Chen P Zhao J Wang Y Wang M Long H Liang D Huang L Wen Z Li W Li X Feng H Zhao H Zhu P Li M Wang Q Li G H3.3 actively marks enhancers and primes gene transcription via opening higher-ordered chromatin Genes & development 2013 27 2109 24 10.1101/gad.222174.113 24065740 PMC3850095 http://f1000.com/prime/718118332 · DOI
  70. [72]Goldberg AD Banaszynski LA Noh K Lewis PW Elsaesser SJ Stadler S Dewell S Law M Guo X Li X Wen D Chapgier A DeKelver RC Miller JC Lee Y Boydston EA Holmes MC Gregory PD Greally JM Rafii S Yang C Scambler PJ Garrick D Gibbons RJ Higgs DR Cristea IM Urnov FD Zheng D Allis CD Distinct factors control histone variant H3.3 localization at specific genomic regions Cell 2010 140 678 91 10.1016/j.cell.2010.01.003 20211137 PMC2885838 · DOI
  71. [73]Banaszynski LA Wen D Dewell S Whitcomb SJ Lin M Diaz N Elsässer SJ Chapgier A Goldberg AD Canaani E Rafii S Zheng D Allis CD Hira-dependent histone H3.3 deposition facilitates PRC2 recruitment at developmental loci in ES cells Cell 2013 155 107 20 10.1016/j.cell.2013.08.061 24074864 PMC3838450 · DOI
  72. [74]Wan Y Saleem RA Ratushny AV Roda O Smith JJ Lin C Chiang J Aitchison JD Role of the histone variant H2A.Z/Htz1p in TBP recruitment, chromatin dynamics, and regulated expression of oleate-responsive genes Molecular and cellular biology 2009 29 2346 58 10.1128/MCB.01233-08 19273605 PMC2668375 http://f1000.com/prime/719781868 · DOI
  73. [76]Li Z Gadue P Chen K Jiao Y Tuteja G Schug J Li W Kaestner KH Foxa2 and H2A.Z mediate nucleosome depletion during embryonic stem cell differentiation Cell 2012 151 1608 16 10.1016/j.cell.2012.11.018 23260146 PMC3530164 http://f1000.com/prime/718685256 · DOI
  74. [78]Menet JS Pescatore S Rosbash M CLOCK:BMAL1 is a pioneer-like transcription factor Genes & development 2014 28 8 13 10.1101/gad.228536.113 24395244 PMC3894415 http://f1000.com/prime/718229803 · DOI
  75. [79]Chen P Wang Y Li G Dynamics of histone variant H3.3 and its coregulation with H2A.Z at enhancers and promoters Nucleus (Austin, Tex.) 2014 5 21 7 10.4161/nucl.28067 24637397 PMC4028350 · DOI
  76. [80]Dalvai M Bellucci L Fleury L Lavigne A Moutahir F Bystricky K H2A.Z-dependent crosstalk between enhancer and promoter regulates cyclin D1 expression Oncogene 2013 32 4243 51 10.1038/onc.2012.442 23108396 http://f1000.com/prime/718099455 · DOI
  77. [82]Dryhurst D Ausió J Histone H2A.Z deregulation in prostate cancer Cause or effect? Cancer metastasis reviews 2014 33 429 39 10.1007/s10555-013-9486-9 24398858 PMC4113680 · DOI
  78. [83]Gévry N Hardy S Jacques P Laflamme L Svotelis A Robert F Gaudreau L Histone H2A.Z is essential for estrogen receptor signaling Genes & development 2009 23 1522 33 10.1101/gad.1787109 19515975 PMC2704467 · DOI

Cited by

Sorted by citations

Authors
Subramanian, V., Fields, P. A., & Boyer, L. A.
Affiliations
Massachusetts Institute of Technology (US)
ORCID
Venue
F1000Prime Reports
Publisher
Faculty Opinions Ltd
Published
2015-01-05
Volume
7
Pages
01-01
ISSN
2051-7599 (ISSN-L)
DOI
10.12703/p7-01
PMC
PMC4311278
OpenAlex
W1979014200
Cited by
102
References
5
Citations by year
2026: 3 · 2025: 2 · 2024: 5 · 2023: 10 · 2022: 11 · 2021: 9 · 2020: 11 · 2019: 10 · 2018: 14 · 2017: 12 · 2016: 8 · 2015: 7
FWCI
1.32
Type
journal article
Language
en
Open access
Locations
  • F1000Prime Reports (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
Funders
National Institute of General Medical Sciences (T32GM007287)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords
H2A.Z, histone variants, nucleosome, chromatin regulation, transcriptional regulation, histone modifications, transcription factors, transcriptional programs, metazoans, chromatin state

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review