Cited by 340DNA Repair MechanismsGenomics and Chromatin DynamicsChromatin Remodeling and Cancer

Histone H2A.Z Controls a Critical Chromatin Remodeling Step Required for DNA Double-Strand Break Repair

Open access
Xu, Ye, Ayrapetov, Marina K., Xu, Chang, Gursoy-Yuzugullu, Ozge, Hu, Yiduo, Price, Brendan D.·2012·Molecular Cell

Abstract

Chromatin remodeling during DNA double-strand break (DSB) repair is required to facilitate access to and repair of DSBs. This remodeling requires increased acetylation of histones and a shift in nucleosome organization to create open, relaxed chromatin domains. However, the underlying mechanism driving changes in nucleosome structure at DSBs is poorly defined. Here, we demonstrate that histone H2A.Z is exchanged onto nucleosomes at DSBs by the p400 remodeling ATPase. H2A.Z exchange at DSBs shifts the chromatin to an open conformation and is required for acetylation and ubiquitination of histones and for loading of the brca1 complex. H2A.Z exchange also restricts single-stranded DNA production by nucleases and is required for loading of the Ku70/Ku80 DSB repair protein. H2A.Z exchange therefore promotes specific patterns of histone modification and reorganization of the chromatin architecture, leading to the assembly of a chromatin template that is an efficient substrate for the DSB repair machinery.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.molcel.2012.09.026

Cites

56 of 56 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

1 of the 57 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Xu, Y., Ayrapetov, M. K., Xu, C., Gursoy-Yuzugullu, O., Hu, Y., & Price, B. D.
Affiliations
Harvard University (US)
Corresponding author
Price, Brendan D.
Venue
Molecular Cell
Publisher
Elsevier BV
Published
2012-12
Volume
48
Issue
5
Pages
723-733
ISSN
1097-2765 (ISSN-L)
OpenAlex
W2118997256
Cited by
336
References
57
Citations by year
2026: 7 · 2025: 15 · 2024: 29 · 2023: 14 · 2022: 30 · 2021: 25 · 2020: 33 · 2019: 23 · 2018: 23 · 2017: 30 · 2016: 17 · 2015: 29 · 2014: 33 · 2013: 27 · 2012: 1
FWCI
11.58
Type
journal article
Language
en
Open access
Locations
  • Molecular Cell (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • U.S. Department of Defense
  • National Cancer Institute (R01CA064585, R01CA093602, CA64585, CA93602)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords
histone H2A.Z, DNA double-strand break repair, chromatin remodeling, histone acetylation, histone ubiquitination, nucleosome structure, Ku70/Ku80, single-stranded DNA, histone modifications
MeSH terms
Ku Autoantigen, Acetylation, Adenosine Triphosphatases, Binding Sites, Binding, Competitive, Carrier Proteins, DNA Repair, DNA-Binding Proteins, Dose-Response Relationship, Radiation, Endodeoxyribonucleases, HeLa Cells, Histones, Humans, Nuclear Proteins, Nucleic Acid Conformation, Nucleosomes, Time Factors, Transfection, RNA Interference, Antigens, Nuclear, Chromatin Assembly and Disassembly, DNA Breaks, Double-Stranded, Ubiquitination, HEK293 Cells, DNA End-Joining Repair

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review