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Effect of Galactooligosaccharides on Calcium Absorption and Preventing Bone Loss in Ovariectomized Rats
Abstract
The effects of galactooligosaccharides (GOS), a mixture of galactosyl oligosaccharides formed from lactose by the transgalactosyl reaction of beta-D-galactosidase derived from Bacillus circulans, on calcium absorption and prevention of bone loss were examined in ovariectomized (OVX) Wistar rats. Rats fed on a diet containing GOS absorbed calcium more efficiently than those on the control diet after 8-10 days and 18-20 days, and the bone (femur and tibia) ash weight and tibia calcium content of OVX rats fed on the GOS diet were significantly higher than those of the control animals. Although the serum total cholesterol of the ovariectomized rats was significantly elevated, GOS produced a significant hypocholesterolemic effect in the OVX rats. GOS, which is fermented by bacteria in the lower part of the intestine, enhanced volatile fatty acid production, and thus prevented bone loss and lower serum total cholesterol concentration in the ovariectomized rats.
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Cited by
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The gut-bone axis: How bacterial metabolites bridge the distance
Zaiss, M. M., Jones, R. M., Schett, G., & Pacifici, R. (2019) · Journal of Clinical Investigation · doi:10.1172/jci128521 · Cited by 403
Morotomi, M., Nagai, F., & Watanabe, Y. (2012) · International Journal of Systematic and Evolutionary Microbiology · doi:10.1099/ijs.0.026989-0 · Cited by 297
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Whisner, C. M., & Castillo, L. F. (2018) · Calcified Tissue International · doi:10.1007/s00223-017-0339-3 · Cited by 292
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Metadata
- Authors
- Chonan, O., Matsumoto, K., & Watanuki, M.
- Venue
- Bioscience, Biotechnology, and Biochemistry
- Publisher
- Informa UK Limited
- Published
- 1995-01
- Volume
- 59
- Issue
- 2
- Pages
- 236-239
- ISSN
- 0916-8451 (ISSN-L)
- 1347-6947
- OpenAlex
- W2002604531
- Cited by
- 164
- References
- 0
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chonan, O., Matsumoto, K., & Watanuki, M. (1995). Effect of Galactooligosaccharides on Calcium Absorption and Preventing Bone Loss in Ovariectomized Rats. Bioscience, Biotechnology, and Biochemistry. https://doi.org/10.1271/bbb.59.236
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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