The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Inhibitory Effects of Apple Polyphenol on Induced Histamine Release from RBL-2H3 Cells and Rat Mast Cells
Abstract
The anti-allergic activities of polyphenol fractions extracted from immature fruits of apple (Rosaceae, Malus sp.) were evaluated by in vitro assays. A crude apple polyphenol (CAP) fraction, which had been obtained from the juice of immature apples by reverse-phase column chromatography, was further purified by LH-20 column chromatography to obtain an apple condensed tannin (ACT) fraction consisting of linear oligomeric epicatechins from the dimer to pentadecamer. ACT strongly inhibited the release of histamine from rat basophilic leukemia (RBL-2H3) cells stimulated by the antigen-stimulation and from rat peritoneal mast cells stimulated by compound 48/80. The IC50 values for histamine release were 30 micrograms/ml and 25 micrograms/ml, respectively. ACT also inhibited hyaluronidase activity and the increase in intracellular free calcium concentration in RBL-2H3 cells stimulated with the antigen. These results suggest that ACT affected early signal transduction including the calcium influx.
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Cites
Ariga, T., & Hamano, M. (1990) · Agricultural and Biological Chemistry · doi:10.1080/00021369.1990.10870369 · Cited by 123
Cited by
Dietary polyphenols and their biological significance
Han, X., Shen, T., & Lou, H. (2007) · International Journal of Molecular Sciences · doi:10.3390/i8090950 · Cited by 1,081
“They also inhibited hyaluronidase activity and increase in intracellular free calcium concentration in RBL-2H3 cells stimulated with the antigen [152].”
BackgroundSugiyama, H., Akazome, Y., Shoji, T., Yamaguchi, A., Yasue, M., Kanda, T., & Ohtake, Y. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf070569k · Cited by 329
Self-citationLab and pilot-scale ultrasound-assisted water extraction of polyphenols from apple pomace
Pingret, D., Fabiano-Tixier, A.-S., Bourvellec, C. L., Renard, C. M. G. C., & Chemat, F. (2012) · Journal of Food Engineering · doi:10.1016/j.jfoodeng.2012.01.026 · Cited by 326
Research Progress on Therapeutic Effect and Mechanism of Propolis on Wound Healing
Yang, J., Pi, A., Yan, L., Li, J., Nan, S., Zhang, J., & Hao, Y. (2022) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2022/5798941 · Cited by 48
Metadata
- Authors
- KANDA, T., AKIYAMA, H., YANAGIDA, A., TANABE, M., GODA, Y., TOYODA, M., TESHIMA, R., & SAITO, Y.
- Venue
- Bioscience, Biotechnology, and Biochemistry
- Publisher
- Informa UK Limited
- Published
- 1998-01
- Volume
- 62
- Issue
- 7
- Pages
- 1284-1289
- ISSN
- 0916-8451 (ISSN-L)
- 1347-6947
- OpenAlex
- W2041553468
- Cited by
- 172
- References
- 1
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Inhibitory Effects of Apple Polyphenol on Induced Histamine Release from RBL-2H3 Cells and Rat Mast Cells. https://app.cochat.ai/papers/10.1271/bbb.62.1284
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- KANDA, T., AKIYAMA, H., YANAGIDA, A., TANABE, M., GODA, Y., TOYODA, M., TESHIMA, R., & SAITO, Y. (1998). Inhibitory Effects of Apple Polyphenol on Induced Histamine Release from RBL-2H3 Cells and Rat Mast Cells. Bioscience, Biotechnology, and Biochemistry. https://doi.org/10.1271/bbb.62.1284
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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