Defined plant extracts can protect human cells against combined xenobiotic effects
Open accessAbstract
BACKGROUND: Pollutants representative of common environmental contaminants induce intracellular toxicity in human cells, which is generally amplified in combinations. We wanted to test the common pathways of intoxication and detoxification in human embryonic and liver cell lines. We used various pollutants such as Roundup residues, Bisphenol-A and Atrazine, and five precise medicinal plant extracts called Circ1, Dig1, Dig2, Sp1, and Uro1 in order to understand whether specific molecular actions took place or not. METHODS: Kidney and liver are major detoxification organs. We have studied embryonic kidney and hepatic human cell lines E293 and HepG2. The intoxication was induced on the one hand by a formulation of one of the most common herbicides worldwide, Roundup 450 GT+ (glyphosate and specific adjuvants), and on the other hand by a mixture of Bisphenol-A and Atrazine, all found in surface waters, feed and food. The prevention and curative effects of plant extracts were also measured on mitochondrial succinate dehydrogenase activity, on the entry of radiolabelled glyphosate (in Roundup) in cells, and on cytochromes P450 1A2 and 3A4 as well as glutathione-S-transferase. RESULTS: Clear toxicities of pollutants were observed on both cell lines at very low sub-agricultural dilutions. The prevention of such phenomena took place within 48 h with the plant extracts tested, with success rates ranging between 25-34% for the E293 intoxicated by Roundup, and surprisingly up to 71% for the HepG2. By contrast, after intoxication, no plant extract was capable of restoring E293 viability within 48 h, however, two medicinal plant combinations did restore the Bisphenol-A/Atrazine intoxicated HepG2 up to 24-28%. The analysis of underlying mechanisms revealed that plant extracts were not capable of preventing radiolabelled glyphosate from entering cells; however Dig2 did restore the CYP1A2 activity disrupted by Roundup, and had only a mild preventive effect on the CYP3A4, and no effect on the glutathione S-transferase. CONCLUSIONS: Environmental pollutants have intracellular effects that can be prevented, or cured in part, by precise medicinal plant extracts in two human cell lines. This appears to be mediated at least in part by the cytochromes P450 modulation.
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Plant extracts containing ferulic and caffeic acids were able to promote detoxification of embryonic kidney cells after R contamination.
“Accordingly, we previously demonstrated that plant extracts containing ferulic and caffeic acids were able to promote detoxification of embryonic kidney cells after R contamination (Gasnier et al., 2011).”
From RETRACTED: Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize (2012) · cites this paper as Gasnier et al., 2011
Plant extracts containing ferulic and caffeic acids were able to promote detoxification of human embryonic kidney cells after culture in the presence of R.
“This possibility is consistent with our previous observation that plant extracts containing ferulic and caffeic acids were able to promote detoxification of human embryonic kidney cells after culture in the presence of R [40].”
From Republished study: long-term toxicity of a Roundup herbicide and a Roundup-tolerantgenetically modified maize (2014) · cites this paper as [40]
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Cites
1 retracted
Williams, G. M., Kroes, R., & Munro, I. C. (2000) · Regulatory Toxicology and Pharmacology · doi:10.1006/rtph.1999.1371 · Cited by 864 · see citing works
RetractedMosmann, T. (1983) · Journal of Immunological Methods · doi:10.1016/0022-1759(83)90303-4 · Cited by 56,104 · see citing works
Habig, W. H., Pabst, M. J., & Jakoby, W. B. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42083-8 · Cited by 18,394 · see citing works
Rapid colorimetric assay for cell growth and survival
Denizot, F., & Lang, R. (1986) · Journal of Immunological Methods · doi:10.1016/0022-1759(86)90368-6 · Cited by 4,907 · see citing works
Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines
Gasnier, C., Dumont, C., Benachour, N., Clair, E., Chagnon, M.-C., & Séralini, G.-E. (2009) · Toxicology · doi:10.1016/j.tox.2009.06.006 · Cited by 658 · see citing works
Self-citationDifferential effects of glyphosate and roundup on human placental cells and aromatase
Richard, S., Moslemi, S., Sipahutar, H., Benachour, N., & Seralini, G.-E. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7728 · Cited by 619 · see citing works
Self-citationWesterink, W. M. A., & Schoonen, W. G. E. J. (2007) · Toxicology in Vitro · doi:10.1016/j.tiv.2007.05.014 · Cited by 544 · see citing works
Benachour, N., & Séralini, G.-E. (2009) · Chemical Research in Toxicology · doi:10.1021/tx800218n · Cited by 428 · see citing works
Self-citationUse of metabolically competent human hepatoma cells for the detection of mutagens and antimutagens
Knasmüller, S., Parzefall, W., Sanyal, R., Ecker, S., Schwab, C., Uhl, M., Mersch‐Sundermann, V., Williamson, G., Hietsch, G., Langer, T., et al. (1998) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(97)00297-2 · Cited by 415 · see citing works
Knasmüller, S., Mersch‐Sundermann, V., Kevekordes, S., Darroudi, F., Huber, W. W., Hoelzl, C., Bichler, J., & Majer, B. J. (2004) · Toxicology · doi:10.1016/j.tox.2004.02.008 · Cited by 359 · see citing works
Protective effect of rutin on paracetamol- and CCl4-induced hepatotoxicity in rodents
Janbaz, K. H., Saeed, S. A., & Gilani, A. H. (2002) · Fitoterapia · doi:10.1016/s0367-326x(02)00217-4 · Cited by 336 · see citing works
Chemical and biological properties of indole glucosinolates (glucobrassicins): A review
McDanell, R. E., McLean, A. E. M., Hanley, A. B., Heaney, R. K., & Fenwick, G. R. (1988) · Food and Chemical Toxicology · doi:10.1016/0278-6915(88)90042-7 · Cited by 277 · see citing works
Tunón, H., Olavsdotter, C., & Bohlin, L. (1995) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(95)01285-l · Cited by 266 · see citing works
Banno, N., Akihisa, T., Tokuda, H., Yasukawa, K., Higashihara, H., Ukiya, M., Watanabe, K., Kimura, Y., Hasegawa, J., & Nishino, H. (2004) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.68.85 · Cited by 261 · see citing works
Galloway, T. S., Cipelli, R., Guralnik, J. M., Ferrucci, L., Bandinelli, S., Corsi, A. M., Money, C., McCormack, P., & Melzer, D. R. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.1002367 · Cited by 234 · see citing works
Time- and dose-dependent effects of Roundup on human embryonic and placental cells
Benachour, N., Sipahutar, H., Moslemi, S., Gasnier, C., Travert, C., & Séralini, G. E. (2007) · Archives of Environmental Contamination and Toxicology · doi:10.1007/s00244-006-0154-8 · Cited by 226 · see citing works
Self-citationA comparison of the effects of three GM corn varieties on mammalian health
de Vendômois, J. S., Roullier, F., Cellier, D., & Séralini, G.-E. (2009) · International Journal of Biological Sciences · doi:10.7150/ijbs.5.706 · Cited by 160 · see citing works
Self-citationSilymarin Retards the Progression of Alcohol-Induced Hepatic Fibrosis in Baboons
Lieber, C. S., Leo, M. A., Cao, Q., Ren, C., & DeCarli, L. M. (2003) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200310000-00013 · Cited by 156 · see citing works
Apáti, P., Szentmihályi, K., Kristó, S. T., Papp, I., Vinkler, P., Szőke, É., & Kéry, Á. (2003) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/s0731-7085(03)00207-3 · Cited by 151 · see citing works
Janbaz, K. H., & Gilani, A. H. (2000) · Fitoterapia · doi:10.1016/s0367-326x(99)00098-2 · Cited by 141 · see citing works
Schoonen, W. G. E. J., de Roos, J. A. D. M., Westerink, W. M. A., & Débiton, E. (2005) · Toxicology in Vitro · doi:10.1016/j.tiv.2005.01.002 · Cited by 132 · see citing works
Antihepatotoxic Actions of Flavonolignans fromSilybum marianumFruits
Hikino, H., Kiso, Y., Wagner, H., & Fiebig, M. (1984) · Planta Medica · doi:10.1055/s-2007-969690 · Cited by 121 · see citing works
Protective effects of ursolic acid and oleanolic acid in leukemic cells
Ovesná, Z., Kozics, K., & Slameňová, D. (2006) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2006.03.008 · Cited by 119 · see citing works
Izzotti, A., Kanitz, S., D’Agostini, F., Camoirano, A., & Flora, S. D. (2009) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2009.07.011 · Cited by 117 · see citing works
Bénachour, N., Moslemi, S., Sipahutar, H., & Séralini, G. (2007) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2007.03.033 · Cited by 115 · see citing works
Self-citationInhibition of Activator Protein 1 Activity by Berberine in Human Hepatoma Cells
Fukuda, K., Hibiya, Y., Mutoh, M., Koshiji, M., Akao, S., & Fujiwara, H. (1999) · Planta Medica · doi:10.1055/s-2006-960795 · Cited by 112 · see citing works
Protective effects of ellagic and chlorogenic acids against oxidative stress in PC12 cells
Pavlica, S., & Gebhardt, R. (2005) · Free Radical Research · doi:10.1080/09670260500197660 · Cited by 107 · see citing works
Lin, S.-C., Lin, C., Lin, C., Lin, Y., Chen, C.-F., Chen, I.-C., & Wang, L. (2002) · Journal of Biomedical Science · doi:10.1007/bf02256533 · Cited by 95 · see citing works
Atrazine‐induced changes in aromatase activity in estrogen sensitive target tissues
Holloway, A. C., Anger, D. A., Crankshaw, D., Wu, M., & Foster, W. G. (2007) · Journal of Applied Toxicology · doi:10.1002/jat.1275 · Cited by 90 · see citing works
Lin, S.-C., Chung, T.-C., Lin, C., Ueng, T., Lin, Y., Lin, S.-Y., & Wang, L. (2000) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x00000210 · Cited by 88 · see citing works
Taraxacum officinaleprotects against cholecystokinin-induced acute pancreatitis in rats
Seo, S.-W. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i4.597 · Cited by 74 · see citing works
Metabolism and Interaction of Bisphenol A in Human Hepatic Cytochrome P450 and Steroidogenic CYP17.
Niwa, T., Fujimoto, M., Kishimoto, K., Yabusaki, Y., Ishibashi, F., & Katagiri, M. (2001) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.24.1064 · Cited by 72 · see citing works
Efficacy of a plant extract (Chelidonium majus L.) in combating induced hepatocarcinogenesis in mice
Biswas, S. J., Bhattacharjee, N., & Khuda‐Bukhsh, A. R. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.12.009 · Cited by 72 · see citing works
Contribution of Caffeine and Flavanols in the Induction of Hepatic Phase II Activities by Green Tea
Bu-Abbas, A., Clifford, M. N., Walker, R., & Ioannides, C. (1998) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(98)00019-2 · Cited by 68 · see citing works
Casas, E., Bonilla, E., Ducolomb, Y., & Betancourt, M. (2009) · Toxicology in Vitro · doi:10.1016/j.tiv.2009.09.004 · Cited by 56 · see citing works
Human-derived cell lines to study xenobiotic metabolism
Urani, C., Doldi, M., Crippa, S., & Camatini, M. (1998) · Chemosphere · doi:10.1016/s0045-6535(98)00321-x · Cited by 55 · see citing works
The bifidogenic effect of Taraxacum officinale root
Trojanová, I., Rada, V., Kokoška, L., & Vlková, E. (2004) · Fitoterapia · doi:10.1016/j.fitote.2004.09.010 · Cited by 55 · see citing works
Dig1 protects against cell death provoked by glyphosate-based herbicides in human liver cell lines
Gasnier, C., Benachour, N., Clair, E., Travert, C., Langlois, F., Laurant, C., Decroix-Laporte, C., & Séralini, G.-E. (2010) · Journal of Occupational Medicine and Toxicology · doi:10.1186/1745-6673-5-29 · Cited by 49 · see citing works
Self-citationGebhardt, R. (2011) · Arzneimittelforschung · doi:10.1055/s-0031-1299836 · Cited by 45 · see citing works
Jondeau, A., Dahbi, L., Bani-Estivals, M.-H., & Chagnon, M. (2006) · Toxicology · doi:10.1016/j.tox.2006.07.007 · Cited by 42 · see citing works
Antimicrobial activity of Solidago virgaurea L. from in vitro cultures
Thiem, B., & Goślińska-Kuźniarek, O. (2002) · Fitoterapia · doi:10.1016/s0367-326x(02)00180-6 · Cited by 39 · see citing works
Curwin, B., Hein, M. J., Barr, D. B., & Striley, C. (2009) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/jes.2009.15 · Cited by 23 · see citing works
TAKAHASHI, K., Horie, M., & Nobuji, A. O. B. A. (2001) · Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) · doi:10.3358/shokueishi.42.304 · Cited by 21 · see citing works
MR 20492 and MR 20494: two indolizinone derivatives that strongly inhibit human aromatase
Auvray, P., Sourdaine, P., Moslemi, S., Séralini, G., Sonnet, P., Enguehard‐Gueiffier, C., Guillon, J., Dallemagne, P., Bureau, R., & Rault, S. (1999) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(99)00093-x · Cited by 18 · see citing works
Self-citationAntihepatotoxic Activity ofChelidonium majus
Mitra, S., Gole, M. K., Samajdar, K., Sur, R. K., & Chakraborty, B. N. (1992) · Pharmaceutical Biology · doi:10.3109/13880209209053974 · Cited by 17 · see citing works
Inhibition of Human Hepatic Cytochrome P450s and Steroidogenic CYP17 by Nonylphenol.
Niwa, T., Maekawa, Y., Fujimoto, M., Kishimoto, K., Yabusaki, Y., Ishibashi, F., & Katagiri, M. (2002) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.25.235 · Cited by 15 · see citing works
[Antimutagenic activity and metabolic transformation of ranunculin by rat liver microsomes].
Rz, L., Hp, P., & Xj, J. (1993) · PubMed · Cited by 3 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Wiebel FJ Lambiotte M Singh J Summer KH Wolff T Expression of carcinogen-metabolizing enzymes in continuous cultures of mammalian cells 1984 Biochemicals Basis of Chemical Carcinogenesis, Raven Press, New York 77 88
Cited by
Sorted by citations
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Self-citationEthoxylated adjuvants of glyphosate-based herbicides are active principles of human cell toxicity
Mesnage, R., Bernay, B., & Séralini, G.-E. (2013) · Toxicology · doi:10.1016/j.tox.2012.09.006 · Cited by 424 · see citing works
Self-citationToxicity of formulants and heavy metals in glyphosate-based herbicides and other pesticides
Defarge, N., de Vendômois, J. S., & Séralini, G. (2017) · Toxicology Reports · doi:10.1016/j.toxrep.2017.12.025 · Cited by 426 · see citing works
Self-citationSéralini, G.-E., Clair, E., Mesnage, R., Gress, S., Defarge, N., Malatesta, M., Hennequin, D., & de Vendômois, J. S. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.08.005 · Cited by 397 · see citing works
Self-citationRetractedSéralini, G.-E., Clair, E., Mesnage, R., Gress, S., Defarge, N., Malatesta, M., Hennequin, D., & de Vendômois, J. S. (2014) · Environmental Sciences Europe · doi:10.1186/s12302-014-0014-5 · Cited by 299 · see citing works
Self-citationEmilie Clair, A., Mesnage, R., Travert, C., & Séralini, G. (2011) · Toxicology in Vitro · doi:10.1016/j.tiv.2011.12.009 · Cited by 231 · see citing works
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Self-citationChaufan, G., Coalova, I., & de Molina, M. D. C. R. (2014) · International Journal of Toxicology · doi:10.1177/1091581813517906 · Cited by 115 · see citing works
Mesnage, R., Ibragim, M., Mandrioli, D., Falcioni, L., Tibaldi, E., Belpoggi, F., Brandsma, I., Bourne, E., Savage, E., Mein, C. A., et al. (2021) · Toxicological Sciences · doi:10.1093/toxsci/kfab143 · Cited by 103 · see citing works
Self-citationAbarikwu, S. O., Akiri, O. F., Durojaiye, M. A., & Adenike, A. (2014) · Toxicology Mechanisms and Methods · doi:10.3109/15376516.2014.989349 · Cited by 91 · see citing works
Glyphosate Exposure in a Farmer’s Family
Mesnage, R., Moesch, C., Grand, R. L., Lauthier, G., de Vendômois, J. S., Gress, S., & Séralini, G. (2012) · Journal of Environmental Protection · doi:10.4236/jep.2012.39115 · Cited by 72 · see citing works
Self-citationVanlaeys, A., Dubuisson, F., Séralini, G., & Travert, C. (2018) · Toxicology in Vitro · doi:10.1016/j.tiv.2018.01.002 · Cited by 69 · see citing works
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Jarrell, Z. R., Ahammad, M. U., & Benson, A. P. (2020) · Veterinary and Animal Science · doi:10.1016/j.vas.2020.100126 · Cited by 60 · see citing works
Séralini, G., Mesnage, R., Defarge, N., Gress, S., Hennequin, D., Emilie Clair, A., Malatesta, M., & de Vendômois, J. S. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.11.007 · Cited by 56 · see citing works
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Lasheras, F. S., Nieto, P. J. G., García–Gonzalo, E., Bonavera, L., & Juez, F. J. D. C. (2020) · Scientific Reports · doi:10.1038/s41598-020-68636-5 · Cited by 22 · see citing works
Ferguson, S., Mesnage, R., & Antoniou, M. N. (2022) · Toxics · doi:10.3390/toxics10110711 · Cited by 23 · see citing works
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Mesnage, R., & Séralini, G. (2014) · Wiley eBooks · doi:10.1002/9781118474563.ch10 · Cited by 8 · see citing works
Self-citationFathi, M. A., Shen, D., Abdelsalam, A. M., & Li, C. (2023) · Animal Biotechnology · doi:10.1080/10495398.2023.2214601 · Cited by 4 · see citing works
Defarge, N., Mesnage, R., Gress, S., & Séralini, G. (2012) · Journal of Toxicology and Environmental Health Part B · doi:10.1080/10937404.2012.736857 · Cited by 4 · see citing works
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Mesnage, R., Ibragim, M., Mandrioli, D., Falcioni, L., Tibaldi, E., Brandsma, I., Belpoggi, F., Bourne, E., Savage, E., Mein, C. A., et al. (2021) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5061/dryad.1g1jwstxk · Cited by 3 · see citing works
Self-citationWang, R., Chen, J., & Wang, P. (2025) · Food and Chemical Toxicology · doi:10.1016/j.fct.2025.115668 · Cited by 2 · see citing works
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Peksen, D. Y. (2016) · IOSR Journal of Engineering · doi:10.9790/3021-067014757 · Cited by 1 · see citing works
Environmental Endocrine Disrupting Chemicals and Cardiac Arrhythmogenesis
Gao, X. (2015) · OhioLink ETD Center (Ohio Library and Information Network) · Cited by 1 · see citing works
Aubán, A. J. B. (2025) · Swiss Journal of Radiology and Nuclear Medicine · doi:10.59667/sjoranm.v20i1.14
- Authors
- Gasnier, C., Laurant, C., Decroix-Laporte, C., Mesnage, R., Clair, E., Travert, C., & Séralini, G.-E.
- Affiliations
- Université de Caen Normandie (FR)
- Centre National de la Recherche Scientifique (FR)
- ORCID
- Mesnage, Robin
- Venue
- Journal of Occupational Medicine and Toxicology
- Published
- 2011-01-20
- Volume
- 6
- Issue
- 1
- Pages
- 3-3
- ISSN
- 1745-6673 (ISSN-L)
- PMC
- PMC3041787
- OpenAlex
- W2163670032
- Cited by
- 31
- References
- 47
- Citations by year
- 2025: 4 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 4 · 2012: 5
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Journal of Occupational Medicine and Toxicology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Portal (King's College London) (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Région Normandie
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Pesticide Exposure and Toxicity
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Keywords
- medicinal plant extracts, xenobiotic toxicity, glyphosate, bisphenol A, atrazine, CYP1A2, CYP3A4, glutathione S-transferase, mitochondrial succinate dehydrogenase, detoxification, hepatotoxicity, nephrotoxicity, HepG2 cells, contaminant mixtures
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