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Cited by 360

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Screening for Tyrosinase Inhibitors among Extracts of Seashore Plants and Identification of Potent Inhibitors from Garcinia subelliptica

MASUDA, Toshiya, YAMASHITA, Daiki, TAKEDA, Yoshio, YONEMORI, Shigetomo·2005·Bioscience, Biotechnology, and Biochemistry

Abstract

The tyrosinase inhibitory activity of methanol extracts of the leaves of 39 plant species growing on the seashore of Iriomote island (Okinawa, Japan) was investigated. The extracts of Hibiscus tiliaceus, Carex pumila, and Garcinia subelliptica showed potent activity among them. The inhibitors in the extract of Garcinia subelliptica were purified by assay-guided fractionation to give two biflavonoids. These were known compounds (2R,3S-5,7,4',5'',7'',3''',4'''-heptahydroxy flavanone[3-8''] flavone and 5,7,4',5'',7'',3''',4'''-heptahydroxy[3-8''] biflavanone), although their strong inhibitory activity toward tyrosinase is revealed for the first time in this work. One of these biflavonoids (2R,3S-5,7,4',5'',7'',3''',4'''-heptahydroxy flavanone[3-8''] flavone) showed much stronger activity (IC50 2.5 microM) than that of kojic acid (IC50 9.1 microM) when L-tyrosine was used as the substrate.

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Metadata

Authors
MASUDA, T., YAMASHITA, D., TAKEDA, Y., & YONEMORI, S.
Venue
Bioscience, Biotechnology, and Biochemistry
Published
2005-01
Volume
69
Issue
1
Pages
197-201
ISSN
  • 0916-8451 (ISSN-L)
  • 1347-6947
OpenAlex
W2023319026
Cited by
360
References
5
FWCI
1.61
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Screening for Tyrosinase Inhibitors among Extracts of Seashore Plants and Identification of Potent Inhibitors from Garcinia subelliptica. https://app.cochat.ai/papers/10.1271/bbb.69.197
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MASUDA, T., YAMASHITA, D., TAKEDA, Y., & YONEMORI, S. (2005). Screening for Tyrosinase Inhibitors among Extracts of Seashore Plants and Identification of Potent Inhibitors from Garcinia subelliptica. Bioscience, Biotechnology, and Biochemistry. https://doi.org/10.1271/bbb.69.197

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