Cited by 44Medicinal Plants and NeuroprotectionMedicinal Plant ResearchPhytochemistry and Biological Activities

Comparative studies on Turkish and Indian Centella asiatica (L.) Urban (gotu kola) samples for their enzyme inhibitory and antioxidant effects and phytochemical characterization

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Orhan, Ilkay Erdogan, Atasu, Erdem, Senol, Fatma Sezer, Ozturk, Nilgun, Demirci, Betul, Das, Kuntal, Sekeroglu, Nazim·2013·Industrial Crops and Products

Abstract

In this study, enzyme inhibitory and antioxidant activity of the ethanol extracts of Centella asiatica (L.) Urban from Turkey and India was examined and the results were compared to those of the standardized extract of the plant obtained from China. Inhibitory activity of these three extracts was screened against four enzymes; acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase (TYRO), and lipoxygenase (LOX) using ELISA microplate reader. Antioxidant activity of the extracts was determined in vitro using 2,2-diphenyl-1-picrylhydrazyl (DPPH), metal-chelation, and ferric-reducing antioxidant power (FRAP) assays. The extracts showed a notable inhibition against BChE and TYRO, while the extracts from Turkey and India displayed lower activity in the antioxidant assays. HPLC analysis indicated that the Turkish plant sample was found to be richest in p-hydroxy-benzoic acid, whilst the Indian sample contained chlorogenic acid in the most abundant amount. α-Copaene was the dominant compound in the essential oil of the plant sample from Turkey.

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Crossref · 10.1016/j.indcrop.2013.03.022

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  • Ethanolic extract of C. asiatica with 10.78% content of asiaticoside and madecassoside exhibits roughly 50% inhibition against acetylcholinesterase.

    “Orhan et al. demonstrated that ethanolic extract of C. asiatica (with 10.78% content of asiaticoside and madecassoside) exhibited roughly 50% inhibition against AChE, indicating that this strong neuroprotective activity can be attributed to the high concentrations of triterpene saponins in the extract. 62”

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Authors
Orhan, I. E., Atasu, E., Senol, F. S., Ozturk, N., Demirci, B., Das, K., & Sekeroglu, N.
Affiliations
Gazi University (TR)
Venue
Industrial Crops and Products
Publisher
Elsevier BV
Published
2013-05
Volume
47
Pages
316-322
ISSN
0926-6690 (ISSN-L)
OpenAlex
W2041630148
Cited by
44
References
35
Citations by year
2026: 1 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 1 · 2021: 4 · 2020: 7 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 4 · 2014: 3 · 2013: 1
FWCI
8.70
Type
journal article
Language
en
Open access
Licence
cc-by-nc-nd
Locations
  • Industrial Crops and Products (publishedVersion)
  • Eastern Mediterranean University Institutional Repository (Eastern Mediterranean University) (submittedVersion, cc-by-nc-nd)
Funders
Türkiye Bilimsel ve Teknolojik Araştırma Kurumu
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
Keywords
Centella asiatica, enzyme inhibition, antioxidant activity, acetylcholinesterase, butyrylcholinesterase, tyrosinase, lipoxygenase, phytochemical profiling, p-hydroxybenzoic acid, chlorogenic acid, α-copaene, essential oils, ethanol extract

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