Effect of Systemic Glucocorticoids on Mortality or Mechanical Ventilation in Patients With COVID-19
Open accessAbstract
The efficacy of glucocorticoids in COVID-19 is unclear. This study was designed to determine whether systemic glucocorticoid treatment in COVID-19 patients is associated with reduced mortality or mechanical ventilation. This observational study included 1,806 hospitalized COVID-19 patients; 140 were treated with glucocorticoids within 48 hours of admission. Early use of glucocorticoids was not associated with mortality or mechanical ventilation. However, glucocorticoid treatment of patients with initial C-reactive protein (CRP) ≥20 mg/dL was associated with significantly reduced risk of mortality or mechanical ventilation (odds ratio, 0.23; 95% CI, 0.08- 0.70), while glucocorticoid treatment of patients with CRP <10 mg/dL was associated with significantly increased risk of mortality or mechanical ventilation (OR, 2.64; 95% CI, 1.39-5.03). Whether glucocorticoid treatment is associated with changes in mortality or mechanical ventilation in patients with high or low CRP needs study in prospective, randomized clinical trials. Journal of Hospital Medicine 2020;15:XXX-XXX. © 2020 Society of Hospital Medicine
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An observational study suggested that patients with Covid-19 have a good response to glucocorticoids when the CRP level is high but a poor response when the level is low.
“An observational study suggesting that patients with Covid-19 have a good response to glucocorticoids when the CRP level is high but a poor response when the level is low is consistent with these findings.101”
From Cytokine storm (2020) · cites this paper as [101]
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- Authors
- Keller, M. J., Kitsis, E. A., Arora, S., Chen, J.-T., Agarwal, S., Ross, M. J., Tomer, Y., & Southern, W.
- Affiliations
- Albert Einstein College of Medicine (US)
- Corresponding author
- Keller, Marla J
- Venue
- Journal of Hospital Medicine
- Publisher
- Wiley
- Published
- 2020-07-22
- Volume
- 15
- Issue
- 8
- Pages
- 489-493
- ISSN
- 1553-5592 (ISSN-L)
- 1553-5606
- PMC
- PMC7518134
- OpenAlex
- W3045374676
- Cited by
- 146
- References
- 14
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 9 · 2023: 10 · 2022: 25 · 2021: 64 · 2020: 32
- FWCI
- 4.29
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Hospital Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Keywords
- COVID-19 pandemic, systemic glucocorticoids, mortality, mechanical ventilation, C-reactive protein, hospitalized patients, corticosteroid therapy, prognostic factors
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Adolescent, Adult, Aged, Aged, 80 and over, C-Reactive Protein, Child, Child, Preschool, Female, Glucocorticoids, Humans, Infant, Male, Middle Aged, Pneumonia, Viral, Prospective Studies, Respiration, Artificial, Time Factors, Comorbidity, Body Mass Index, Coronavirus Infections, Racial Groups, Young Adult, Pandemics
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