The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The use of real-world data in drug repurposing
Open accessAbstract
Drug repurposing, or repositioning, is to identify new uses for existing drugs. Significantly reducing the costs and time-to-market of a medication, drug repurposing has been an alternative tool to accelerate drug development process. On the other hand, 'real world data (RWD)' has been also increasingly used to support drug development process owing to its better representing actual pattern of drug treatment and outcome in real world. In the healthcare domain, RWD refers to data collected from sources other than traditional clinical trials; for example, in electronic health records or claims and billing data. With the enactment of the 21st Century Cures Act, which encourages the use of RWD in drug development and repurposing as well, such increasing trend in RWD use will be expedited. In this context, this review provides an overview of recent progresses in the area of drug repurposing where RWD was used by firstly introducing the increasing trend and regulatory change in the use of RWD in drug development, secondly reviewing published works using RWD in drug repurposing, classifying them in the repurposing strategy, and lastly addressing limitations and advantages of RWDs.
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“The use of real-world data to investigate drug repurposing signals has become an appealing approach (Xu et al., 2015;Park, 2021;Liu and Panagiotakos, 2022;Zong et al., 2022)”
From Drug repurposing for Alzheimer’s disease from 2012–2022—a 10-year literature review (2023) · cites this paper as Park, 2021
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“One such example is found in Observational Health Data Sciences and Informatics (OHDSI) consortium [33].”
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Cited by
Sorted by citations
Drug repurposing for Alzheimer’s disease from 2012–2022—a 10-year literature review
Grabowska, M. E., Huang, A., Wen, Z., Li, B., & Wei, W.-Q. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1257700 · Cited by 55
“In vivo validation included animal models, randomized controlled trials, and real-world data (de fi ned as patient data collected outside of clinical trials — e.g., data from electronic health records [EHRs] and health insurance claims data (Park, 2021)).”
Method
Metadata
- Authors
- Park, K.
- Affiliations
- Yonsei University (KR)
- Corresponding author
- Park, Kyungsoo
- ORCID
- Park, Kyungsoo
- Venue
- Translational and Clinical Pharmacology
- Publisher
- XMLink
- Published
- 2021
- Volume
- 29
- Issue
- 3
- Pages
- 117
- ISSN
- 2289-0882 (ISSN-L)
- 2383-5427
- PMC
- PMC8492393
- OpenAlex
- W3203973511
- Cited by
- 22
- References
- 2
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 7 · 2023: 2 · 2022: 3
- FWCI
- 0.59
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Translational and Clinical Pharmacology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Pharmaceutical Economics and Policy
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Computational Drug Discovery Methods
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Keywords
- drug repurposing, real-world data, drug development, electronic health records, 21st Century Cures Act, regulatory policy
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