Drug repositioning: identifying and developing new uses for existing drugs

The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction

Rosen, R. C., Riley, A., Wagner, G., Osterloh, I. H., Kirkpatrick, J., & Mishra, A. (1997) · Urology · doi:10.1016/s0090-4295(97)00238-0 · Cited by 5,849 · see citing works

Sexual Dysfunction in the United States: Prevalence and Predictors

Laumann, E. O., Paik, A., & Rosen, R. C. (1999) · JAMA · doi:10.1001/jama.281.6.537 · Cited by 5,119 · see citing works

Thalidomide is an inhibitor of angiogenesis.

D'Amato, R. J., Loughnan, M. S., Flynn, E., & Folkman, J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.4082 · Cited by 2,454 · see citing works

Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy.

Pegg, A. E. (1988) · PubMed · Cited by 1,522 · see citing works

Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes.

Sampaio, E. P., Sarno, E. N., Gallily, R., Cohn, Z. A., & Kaplan, G. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.173.3.699 · Cited by 1,191 · see citing works

Polyamine Metabolism: A Potential Therapeutic Target in Trypanosomes

Bacchi, C. J., Nathan, H. C., Hutner, S. H., McCann, P. P., & Sjoerdsma, A. (1980) · Science · doi:10.1126/science.6775372 · Cited by 394 · see citing works

Duloxetine versus placebo in the treatment of stress urinary incontinence

Norton, P., Zinner, N. R., Yalcin, I., et al. (2002) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2002.124840 · Cited by 331 · see citing works

Effects of duloxetine, a combined serotonin and norepinephrine reuptake inhibitor, on central neural control of lower urinary tract function in the chloralose-anesthetized female cat.

Thor, K. B., & Katofiasc, M. A. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10548-x · Cited by 312 · see citing works

Trends in development and approval times for new therapeutics in the United States

Reichert, J. M. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1178 · Cited by 261 · see citing works

Dark remedy: the impact of thalidomide and its revival as a vital medicine

(2001) · Choice Reviews Online · doi:10.5860/choice.39-0973 · Cited by 205 · see citing works

Business Week Online

Flynn, D. A. (2005) · Journal of Business & Finance Librarianship · doi:10.1300/j109v10n02_05 · Cited by 195 · see citing works

Realism in drug discovery—could Cassandra be right?

Horrobin, D. F. (2001) · Nature Biotechnology · doi:10.1038/nbt1201-1099 · Cited by 77 · see citing works

Erectile-dysfunction therapies

Renaud, R. C., & Xuereb, H. (2002) · Nature Reviews Drug Discovery · doi:10.1038/nrd898 · Cited by 32 · see citing works

Three-way street

Freeman, J. R., & Goldstein, J. S. (1990) · Cited by 22 · see citing works

Moving beyond the genome projects

Friedrich, G. A. (1996) · Nature Biotechnology · doi:10.1038/nbt1096-1234 · Cited by 14 · see citing works

Colonizing therapeutic space: the overlooked science of drug husbandry

(2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1315 · Cited by 4 · see citing works

Drug repurposing: progress, challenges and recommendations

Pushpakom, S., Iorio, F., Eyers, P. A., Escott, K. J., Hopper, S., Wells, A., Doig, A., Guilliams, T., Latimer, J., McNamee, C., et al. (2019) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.168 · Cited by 4,718 · see citing works

Combination therapy in combating cancer

Mokhtari, R. B., Homayouni, T. S., Baluch, N., Morgatskaya, E., Kumar, S., Das, B., & Yeger, H. (2017) · Oncotarget · doi:10.18632/oncotarget.16723 · Cited by 2,543 · see citing works

Drug target identification using side-effect similarity

Campillos, M., Kuhn, M., Gavin, A.-C., Jensen, L. J., & Bork, P. (2008) · Science · doi:10.1126/science.1158140 · Cited by 1,248 · see citing works

Limitations of Animal Studies for Predicting Toxicity in Clinical Trials

Van Norman, G. A. (2019) · JACC: Basic to Translational Science · doi:10.1016/j.jacbts.2019.10.008 · Cited by 709 · see citing works

An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people

Nelson, M. R., Wegmann, D., Ehm, M. G., Kessner, D., St. Jean, P., Verzilli, C., Shen, J., Tang, Z., Bacanu, S.-A., Fraser, D., et al. (2012) · Science · doi:10.1126/science.1217876 · Cited by 647 · see citing works

Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs

Jeon, S., Ko, M., Lee, J., Choi, I., Byun, S. Y., Park, S., Shum, D., & Kim, S. (2020) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00819-20 · Cited by 675 · see citing works

Drug repurposing: a promising tool to accelerate the drug discovery process

Parvathaneni, V., Kulkarni, N. S., Muth, A., & Gupta, V. (2019) · Drug Discovery Today · doi:10.1016/j.drudis.2019.06.014 · Cited by 597 · see citing works

Drug repositioning: a brief overview

Jourdan, J.-P., Bureau, R., Rochais, C., & Dallemagne, P. (2020) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.13273 · Cited by 470 · see citing works

Hepatic fibrosis: molecular mechanisms and drug targets

Lotersztajn, S., Julien, B., Teixeira-Clerc, F., Grenard, P., & Mallat, A. (2005) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.45.120403.095906 · Cited by 325 · see citing works

Drug repurposing: far beyond new targets for old drugs

Oprea, T. I., & Mestres, J. (2012) · The AAPS Journal · doi:10.1208/s12248-012-9390-1 · Cited by 285 · see citing works

Microfluidics for cell-based high throughput screening platforms—A review

Du, G., Fang, Q., & den Toonder, J. M. J. (2016) · Analytica Chimica Acta · doi:10.1016/j.aca.2015.11.023 · Cited by 276 · see citing works

A unified drug–target interaction prediction framework based on knowledge graph and recommendation system

Ye, Q., Hsieh, C.-Y., Yang, Z., Kang, Y., Chen, J., Cao, D., He, S., & Hou, T. (2021) · Nature Communications · doi:10.1038/s41467-021-27137-3 · Cited by 261 · see citing works

Applications of Connectivity Map in drug discovery and development

Qu, X. A., & Rajpal, D. K. (2012) · Drug Discovery Today · doi:10.1016/j.drudis.2012.07.017 · Cited by 235 · see citing works

Drug repositioning for orphan diseases

Sardana, D., Zhu, C., Zhang, M., Gudivada, R. C., Yang, L., & Jegga, A. G. (2011) · Briefings in Bioinformatics · doi:10.1093/bib/bbr021 · Cited by 228 · see citing works

A novel signal detection algorithm for identifying hidden drug-drug interactions in adverse event reports

Tatonetti, N. P., Fernald, G. H., & Altman, R. B. (2012) · Journal of the American Medical Informatics Association · doi:10.1136/amiajnl-2011-000214 · Cited by 203 · see citing works

DRAR-CPI: a server for identifying drug repositioning potential and adverse drug reactions via the chemical–protein interactome

Luo, H., Chen, J., Shi, L., Mikailov, M., Zhu, H., Wang, K., He, L., & Yang, L. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr299 · Cited by 206 · see citing works

Design of efficient computational workflows for in silico drug repurposing

Vanhaelen, Q., Mamoshina, P., Aliper, A. M., Artemov, A., Lezhnina, K., Ozerov, I., Labat, I., & Zhavoronkov, A. (2017) · Drug Discovery Today · doi:10.1016/j.drudis.2016.09.019 · Cited by 150 · see citing works

Predicting drug-target interaction network using deep learning model

You, J., McLeod, R. D., & Hu, P. (2019) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2019.03.016 · Cited by 150 · see citing works

DTiGEMS+: drug–target interaction prediction using graph embedding, graph mining, and similarity-based techniques

Thafar, M. A., Olayan, R. S., Ashoor, H., Albaradei, S., Bajic, V. B., Gao, X., Gojobori, T., & Essack, M. (2020) · Journal of Cheminformatics · doi:10.1186/s13321-020-00447-2 · Cited by 143 · see citing works

A medicinal chemistry perspective of drug repositioning: Recent advances and challenges in drug discovery

Pillaiyar, T., Meenakshisundaram, S., Manickam, M., & Sankaranarayanan, M. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112275 · Cited by 140 · see citing works

The Future of Antifungal Drug Therapy: Novel Compounds and Targets

Mota Fernandes, C., Dasilva, D., Haranahalli, K., McCarthy, J. B., Mallamo, J., Ojima, I., & Del Poeta, M. (2021) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01719-20 · Cited by 124 · see citing works

Drug Repurposing Approaches for the Treatment of Influenza Viral Infection: Reviving Old Drugs to Fight Against a Long-Lived Enemy

Pizzorno, A., Padey, B., Terrier, O., & Rosa-Calatrava, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00531 · Cited by 122 · see citing works

Activated microglia targeting dendrimer–minocycline conjugate as therapeutics for neuroinflammation.

Sharma, R., Kim, S.-Y., Sharma, A., Zhang, Z., Kambhampati, S. P., Kannan, S., & Kannan, R. M. (2017) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.7b00569 · Cited by 100 · see citing works

Drug repurposing to fight colistin and carbapenem-resistant bacteria

Peyclit, L., Baron, S. A., & Rolain, J.-M. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00193 · Cited by 91 · see citing works

Repurposing quinacrine for treatment-refractory cancer

Oien, D. B., Pathoulas, C. L., Ray, U., Thirusangu, P., Kalogera, E., & Shridhar, V. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.09.021 · Cited by 87 · see citing works

Artificial intelligence facilitates drug design in the big data era

Wang, L., Ding, J., Pan, L., Cao, D., Jiang, H., & Ding, X. (2019) · Chemometrics and Intelligent Laboratory Systems · doi:10.1016/j.chemolab.2019.103850 · Cited by 80 · see citing works

Pathway-Guided Deep Neural Network toward Interpretable and Predictive Modeling of Drug Sensitivity

Deng, L., Cai, Y., Zhang, W., Yang, W., Gao, B., & Liu, H. (2020) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.0c00331 · Cited by 71 · see citing works

Repositioning chloroquine and metformin to eliminate cancer stem cell traits in pre-malignant lesions

Vazquez-Martin, A., López-Bonetc, E., Cufí, S., Oliveras-Ferraros, C., Del Barco, S., Martin-Castillo, B., & Menendez, J. A. (2011) · Drug Resistance Updates · doi:10.1016/j.drup.2011.04.003 · Cited by 66 · see citing works

Antimicrobial Properties of Antidepressants and Antipsychotics—Possibilities and Implications

Caldara, M., & Marmiroli, N. (2021) · Pharmaceuticals · doi:10.3390/ph14090915 · Cited by 54 · see citing works

New role for FDA-approved drugs in combating antibiotic-resistant bacteria

Andersson, J. A., Fitts, E. C., Kirtley, M. L., Ponnusamy, D., Peniche, A. G., Dann, S. M., Motin, V. L., Chauhan, S., Rosenzweig, J. A., Sha, J., et al. (2016) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00326-16 · Cited by 53 · see citing works

Antifungal therapy of Candida biofilms: Past, present and future

Ajetunmobi, O. H., Badali, H., Romo, J. A., Ramage, G., & Lopez-Ribot, J. L. (2023) · Biofilm · doi:10.1016/j.bioflm.2023.100126 · Cited by 52 · see citing works

Insights on the anticandidal activity of non-antifungal drugs

Moraes, D. C., & Ferreira-Pereira, A. (2019) · Journal de Mycologie Médicale · doi:10.1016/j.mycmed.2019.07.004 · Cited by 37 · see citing works

A Class of Disulfide Compounds Suppresses Ferroptosis by Stabilizing GPX4

Liu, J.-P., Cen, S.-Y., Xue, Z., Wang, T.-X., Gao, Y., Zheng, J., Zhang, C., Hu, J., Nie, S., Xiong, Y., et al. (2022) · ACS Chemical Biology · doi:10.1021/acschembio.2c00445 · Cited by 29 · see citing works

Computational Drug Repositioning and Experimental Validation of Ivermectin in Treatment of Gastric Cancer

Rabben, H.-L., Andersen, G. T., Ianevski, A., Olsen, M. K., Kainov, D., Grønbech, J. E., Wang, T. C., Chen, D., & Zhao, C.-M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.625991 · Cited by 24 · see citing works

Antiepileptic Drugs Inhibit Growth, Dimorphism, and Biofilm Mode of Growth in Human Pathogen <i>Candida albicans</i>

Kathwate, G. H., Shinde, R. B., & Karuppayil, S. M. (2015) · ASSAY and Drug Development Technologies · doi:10.1089/adt.2015.29007.ghkdrrr · Cited by 25 · see citing works

CNS repurposing - Potential new uses for old drugs: Examples of screens for Alzheimer's disease, Parkinson's disease and spasticity

Parsons, C. G. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.08.027 · Cited by 22 · see citing works

Off-Patent drug repositioning

Avram, S., Curpan, R., Halip, L., Bora, A., & Oprea, T. I. (2020) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.0c00826 · Cited by 18 · see citing works

Pitavastatin Calcium Confers Fungicidal Properties to Fluconazole by Inhibiting Ubiquinone Biosynthesis and Generating Reactive Oxygen Species

Li, W., Feng, Y., Feng, Z., Wang, L., Whiteway, M., Lu, H., & Jiang, Y. (2024) · Antioxidants · doi:10.3390/antiox13060667 · Cited by 14 · see citing works

Repurposing of statins for Buruli Ulcer treatment: antimicrobial activity against Mycobacterium ulcerans

Dominguez, J., Mendes, A. I., Pacheco, A. R., Peixoto, M. J., Pedrosa, J., & Fraga, A. G. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1266261 · Cited by 4 · see citing works

Off-label and repurposed use of disulfiram beyond alcohol dependence: A systematic review of clinical and preclinical evidence

Benkő, B.-M., De Brito Parreirinha, N. S., Sebe, I., & Zelkó, R. (2026) · iScience · doi:10.1016/j.isci.2026.115441 · Cited by 2 · see citing works

Facts, Fiction, and the Pharmaceutical Industry

Hanson, J. L. (1986) · Clinical Research Practices and Drug Regulatory Affairs · doi:10.3109/10601338609028595 · Cited by 1 · see citing works

Voluntary Control of Drug Promotion in Sweden

Perman, E. (1990) · New England Journal of Medicine · doi:10.1056/nejm199008303230921 · Cited by 9 · see citing works

Excess in the pharmaceutical industry

Angell, M. E. (2004) · Canadian Medical Association Journal · doi:10.1503/cmaj.1041594 · Cited by 143 · see citing works

Failings of the pharmaceutical industry

Medawar, C. (1988) · doi:10.1007/978-1-349-09571-1_3 · Cited by 2 · see citing works

The pharmaceutical industry as a political player

Abraham, J. M. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11477-2 · Cited by 148 · see citing works