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Cited by 674

The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.

The Role of Oxidative Stress and Antioxidants in Diabetic Complications = دور الإجهاد التأكسدي و المواد المضادة للأكسدة في مضاعفات مرض السكري

Open access
Matough, Fatmah A, Budin, Siti B, Hamid, Zariyantey A, Alwahaibi, Nasar, Mohamed, Jamaludin·2012·Sultan Qaboos University Medical Journal
DOI 10.12816/0003082
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Abstract

Diabetes is considered to be one of the most common chronic diseases worldwide. There is a growing scientific and public interest in connecting oxidative stress with a variety of pathological conditions including diabetes mellitus (DM) as well as other human diseases. Previous experimental and clinical studies report that oxidative stress plays a major role in the pathogenesis and development of complications of both types of DM. However, the exact mechanism by which oxidative stress could contribute to and accelerate the development of complications in diabetic mellitus is only partly known and remains to be clarified. On the one hand, hyperglycemia induces free radicals; on the other hand, it impairs the endogenous antioxidant defense system in patients with diabetes. Endogenous antioxidant defense mechanisms include both enzymatic and non-enzymatic pathways. Their functions in human cells are to counterbalance toxic reactive oxygen species (ROS). Common antioxidants include the vitamins A, C, and E, glutathione (GSH), and the enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GRx). This review describes the importance of endogenous antioxidant defense systems, their relationship to several pathophysiological processes and their possible therapeutic implications in vivo.

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Metadata

Authors
Matough, F. A., Budin, S. B., Hamid, Z. A., Alwahaibi, N., & Mohamed, J.
Venue
Sultan Qaboos University Medical Journal
Publisher
Sultan Qaboos University Medical Journal
Published
2012-02
Volume
12
Issue
1
Pages
5-18
ISSN
  • 2075-051X (ISSN-L)
  • 2075-0528
DOI
10.12816/0003082
OpenAlex
W1508167383
Cited by
674
References
103
FWCI
14.07
Type
journal article
Language
ar
Open access
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CoChat. (2026). Citation check: The Role of Oxidative Stress and Antioxidants in Diabetic Complications = دور الإجهاد التأكسدي و المواد المضادة للأكسدة في مضاعفات مرض السكري. https://app.cochat.ai/papers/10.12816/0003082
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Matough, F. A., Budin, S. B., Hamid, Z. A., Alwahaibi, N., & Mohamed, J. (2012). The Role of Oxidative Stress and Antioxidants in Diabetic Complications = دور الإجهاد التأكسدي و المواد المضادة للأكسدة في مضاعفات مرض السكري. Sultan Qaboos University Medical Journal. https://doi.org/10.12816/0003082

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.