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Prenatal Exposure to Airborne Polycyclic Aromatic Hydrocarbons and Children’s Intelligence at 5 Years of Age in a Prospective Cohort Study in Poland

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Edwards, Susan Claire, Jedrychowski, Wieslaw, Butscher, Maria, Camann, David, Kieltyka, Agnieszka, Mroz, Elzbieta, Flak, Elzbieta, Li, Zhigang, Wang, Shuang, Rauh, Virginia, Perera, Frederica·2010·Environmental Health Perspectives
DOI 10.1289/ehp.0901070
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Abstract

BACKGROUND: In this prospective cohort study of Caucasian mothers and children in Krakow, Poland, we evaluated the role of prenatal exposure to urban air pollutants in the pathogenesis of neurobehavioral disorders. OBJECTIVES: The objective of this study was to investigate the relationship between prenatal polycyclic aromatic hydrocarbon (PAH) exposure and child intelligence at 5 years of age, controlling for potential confounders suspected to play a role in neurodevelopment. METHODS: A cohort of pregnant, healthy, nonsmoking women was enrolled in Krakow, Poland, between 2001 and 2006. During pregnancy, participants were invited to complete a questionnaire and undergo 48-hr personal air monitoring to estimate their babies' exposure, and to provide a blood sample and/or a cord blood sample at the time of delivery. Two hundred fourteen children were followed through 5 years of age, when their nonverbal reasoning ability was assessed using the Raven Coloured Progressive Matrices (RCPM). RESULTS: We found that higher (above the median of 17.96 ng/m3) prenatal exposure to airborne PAHs (range, 1.8-272.2 ng/m3) was associated with decreased RCPM scores at 5 years of age, after adjusting for potential confounding variables (n = 214). Further adjusting for maternal intelligence, lead, or dietary PAHs did not alter this association. The reduction in RCPM score associated with high airborne PAH exposure corresponded to an estimated average decrease of 3.8 IQ points. CONCLUSIONS: These results suggest that prenatal exposure to airborne PAHs adversely affects children's cognitive development by 5 years of age, with potential implications for school performance. They are consistent with a recent finding in a parallel cohort in New York City.

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Metadata

Authors
Edwards, S. C., Jedrychowski, W., Butscher, M., Camann, D., Kieltyka, A., Mroz, E., Flak, E., Li, Z., Wang, S., Rauh, V., & Perera, F.
Venue
Environmental Health Perspectives
Publisher
American Chemical Society (ACS)
Published
2010-09
Volume
118
Issue
9
Pages
1326-1331
ISSN
  • 0091-6765 (ISSN-L)
  • 1552-9924
DOI
10.1289/ehp.0901070
OpenAlex
W1984009402
Cited by
340
References
2
FWCI
14.00
Type
journal article
Language
en
Open access
gold
Licence
creativecommons.org/licenses/by/4.0/ (vor, 2810 d)

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CoChat. (2026). Citation check: Prenatal Exposure to Airborne Polycyclic Aromatic Hydrocarbons and Children’s Intelligence at 5 Years of Age in a Prospective Cohort Study in Poland. https://app.cochat.ai/papers/10.1289/ehp.0901070
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Edwards, S. C., Jedrychowski, W., Butscher, M., Camann, D., Kieltyka, A., Mroz, E., Flak, E., Li, Z., Wang, S., Rauh, V., & Perera, F. (2010). Prenatal Exposure to Airborne Polycyclic Aromatic Hydrocarbons and Children’s Intelligence at 5 Years of Age in a Prospective Cohort Study in Poland. Environmental Health Perspectives. https://doi.org/10.1289/ehp.0901070

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